A clinical warning in the treatment of chlorfenapyr poisoning
Chlorfenapyr, an arylpyrrole-based insecticide, disrupts mitochondrial oxidative phosphorylation to deprive the target organism of energy. Chlorfenapyr poisoning in humans causes distinct clinical signs such as hyperhidrosis, malignant hyperthermia, rhabdomyolysis, and delayed neurological symptoms...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-12-01
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| Series: | Toxicology Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2214750024000866 |
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| _version_ | 1846116029918347264 |
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| author | Yuelei Cheng Yunlai Zhao Hao Li Minmin Duan Lianxiang Li Song Zhou Qingbin Tang Wei Xie Jixue Shi |
| author_facet | Yuelei Cheng Yunlai Zhao Hao Li Minmin Duan Lianxiang Li Song Zhou Qingbin Tang Wei Xie Jixue Shi |
| author_sort | Yuelei Cheng |
| collection | DOAJ |
| description | Chlorfenapyr, an arylpyrrole-based insecticide, disrupts mitochondrial oxidative phosphorylation to deprive the target organism of energy. Chlorfenapyr poisoning in humans causes distinct clinical signs such as hyperhidrosis, malignant hyperthermia, rhabdomyolysis, and delayed neurological symptoms that worsen over time and can be fatal. When treating acute chlorfenapyr poisoning, physicians must consider the latent period and not assume that a patient is safe after an initial response to treatment. It is important to take measures before sudden, fatal symptoms appear. This paper presents three cases of chlorfenapyr poisoning as a warning for physicians to understand its clinical course and treatment. |
| format | Article |
| id | doaj-art-5814eb618a314435b0fa9a74d6f5cad8 |
| institution | Kabale University |
| issn | 2214-7500 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Toxicology Reports |
| spelling | doaj-art-5814eb618a314435b0fa9a74d6f5cad82024-12-19T10:54:28ZengElsevierToxicology Reports2214-75002024-12-0113101703A clinical warning in the treatment of chlorfenapyr poisoningYuelei Cheng0Yunlai Zhao1Hao Li2Minmin Duan3Lianxiang Li4Song Zhou5Qingbin Tang6Wei Xie7Jixue Shi8Department of Emergency, Central Hospital Affiliated to Shandong First Medical University, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, ChinaDepartment of Emergency, Central Hospital Affiliated to Shandong First Medical University, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, ChinaDepartment of Emergency, The Second Affiliated Hospital of Shandong First Medical University, Tai'an, ChinaDepartment of Emergency, Central Hospital Affiliated to Shandong First Medical University, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, ChinaDepartment of Emergency, Central Hospital Affiliated to Shandong First Medical University, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, ChinaDepartment of Emergency, Central Hospital Affiliated to Shandong First Medical University, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, ChinaDepartment of Emergency, Central Hospital Affiliated to Shandong First Medical University, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, ChinaDepartment of Emergency, Central Hospital Affiliated to Shandong First Medical University, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, China; Corresponding author.Department of Emergency, The Second Affiliated Hospital of Shandong First Medical University, Tai'an, ChinaChlorfenapyr, an arylpyrrole-based insecticide, disrupts mitochondrial oxidative phosphorylation to deprive the target organism of energy. Chlorfenapyr poisoning in humans causes distinct clinical signs such as hyperhidrosis, malignant hyperthermia, rhabdomyolysis, and delayed neurological symptoms that worsen over time and can be fatal. When treating acute chlorfenapyr poisoning, physicians must consider the latent period and not assume that a patient is safe after an initial response to treatment. It is important to take measures before sudden, fatal symptoms appear. This paper presents three cases of chlorfenapyr poisoning as a warning for physicians to understand its clinical course and treatment.http://www.sciencedirect.com/science/article/pii/S2214750024000866ChlorfenapyrInsecticideNeurologic symptomologyPoisoningWarning |
| spellingShingle | Yuelei Cheng Yunlai Zhao Hao Li Minmin Duan Lianxiang Li Song Zhou Qingbin Tang Wei Xie Jixue Shi A clinical warning in the treatment of chlorfenapyr poisoning Toxicology Reports Chlorfenapyr Insecticide Neurologic symptomology Poisoning Warning |
| title | A clinical warning in the treatment of chlorfenapyr poisoning |
| title_full | A clinical warning in the treatment of chlorfenapyr poisoning |
| title_fullStr | A clinical warning in the treatment of chlorfenapyr poisoning |
| title_full_unstemmed | A clinical warning in the treatment of chlorfenapyr poisoning |
| title_short | A clinical warning in the treatment of chlorfenapyr poisoning |
| title_sort | clinical warning in the treatment of chlorfenapyr poisoning |
| topic | Chlorfenapyr Insecticide Neurologic symptomology Poisoning Warning |
| url | http://www.sciencedirect.com/science/article/pii/S2214750024000866 |
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