Platelet count and retinopathy of prematurity, a systematic review and meta-analysis
ObjectiveThis study aims to investigate the relationship between platelet count (PLT) and retinopathy of prematurity (ROP), with the goal of identifying a straightforward screening method for the early detection of ROP.MethodsA systematic search was conducted in PubMed, EMBASE, Web of Science, Cochr...
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| Language: | English |
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Pediatrics |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fped.2024.1413271/full |
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| author | Qian Zeng Qian Zeng Ling Wang Yurong Li Yurong Li Yuanyuan Yue Yuanyuan Yue Xin Lv Xin Lv |
| author_facet | Qian Zeng Qian Zeng Ling Wang Yurong Li Yurong Li Yuanyuan Yue Yuanyuan Yue Xin Lv Xin Lv |
| author_sort | Qian Zeng |
| collection | DOAJ |
| description | ObjectiveThis study aims to investigate the relationship between platelet count (PLT) and retinopathy of prematurity (ROP), with the goal of identifying a straightforward screening method for the early detection of ROP.MethodsA systematic search was conducted in PubMed, EMBASE, Web of Science, Cochrane Library, and ClinicalTrials.gov from January 2005 to 26 September 2023. Subsequently, a subgroup analysis was performed.ResultsThis meta-analysis included ten studies involving 1762 neonates, with 747 cases of ROP identified. The pooled analysis indicated a significant decrease in mean platelet count among the ROP group compared to the non-ROP group (mean difference: −18.65, 95% confidence interval: −22.80 to −14.50, P < .00001). Subgroup analysis indicated that the heterogeneity in the results can be attributed to factors such as the location of the studies, gestational age (GA), and publication time.ConclusionDecreased PLT counts may be associated with the occurrence of ROP. The PLT count should be standardized according to the detection location, detection time and GA. |
| format | Article |
| id | doaj-art-58140cfcf98141dfb3ef70a44d5ea5ff |
| institution | Kabale University |
| issn | 2296-2360 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pediatrics |
| spelling | doaj-art-58140cfcf98141dfb3ef70a44d5ea5ff2025-01-14T06:10:27ZengFrontiers Media S.A.Frontiers in Pediatrics2296-23602025-01-011210.3389/fped.2024.14132711413271Platelet count and retinopathy of prematurity, a systematic review and meta-analysisQian Zeng0Qian Zeng1Ling Wang2Yurong Li3Yurong Li4Yuanyuan Yue5Yuanyuan Yue6Xin Lv7Xin Lv8Clinical Laboratory, Children’s Hospital Affiliated to Shandong University, Jinan, ChinaClinical Laboratory, Jinan Children’s Hospital, Jinan, ChinaClinical Laboratory, Children’s Hospital Affiliated to Shandong University, Jinan, ChinaClinical Laboratory, Children’s Hospital Affiliated to Shandong University, Jinan, ChinaClinical Laboratory, Jinan Children’s Hospital, Jinan, ChinaClinical Laboratory, Children’s Hospital Affiliated to Shandong University, Jinan, ChinaClinical Laboratory, Jinan Children’s Hospital, Jinan, ChinaClinical Laboratory, Children’s Hospital Affiliated to Shandong University, Jinan, ChinaClinical Laboratory, Jinan Children’s Hospital, Jinan, ChinaObjectiveThis study aims to investigate the relationship between platelet count (PLT) and retinopathy of prematurity (ROP), with the goal of identifying a straightforward screening method for the early detection of ROP.MethodsA systematic search was conducted in PubMed, EMBASE, Web of Science, Cochrane Library, and ClinicalTrials.gov from January 2005 to 26 September 2023. Subsequently, a subgroup analysis was performed.ResultsThis meta-analysis included ten studies involving 1762 neonates, with 747 cases of ROP identified. The pooled analysis indicated a significant decrease in mean platelet count among the ROP group compared to the non-ROP group (mean difference: −18.65, 95% confidence interval: −22.80 to −14.50, P < .00001). Subgroup analysis indicated that the heterogeneity in the results can be attributed to factors such as the location of the studies, gestational age (GA), and publication time.ConclusionDecreased PLT counts may be associated with the occurrence of ROP. The PLT count should be standardized according to the detection location, detection time and GA.https://www.frontiersin.org/articles/10.3389/fped.2024.1413271/fullplatelet countretinopathy of prematureROPprematuremeta-analysis |
| spellingShingle | Qian Zeng Qian Zeng Ling Wang Yurong Li Yurong Li Yuanyuan Yue Yuanyuan Yue Xin Lv Xin Lv Platelet count and retinopathy of prematurity, a systematic review and meta-analysis Frontiers in Pediatrics platelet count retinopathy of premature ROP premature meta-analysis |
| title | Platelet count and retinopathy of prematurity, a systematic review and meta-analysis |
| title_full | Platelet count and retinopathy of prematurity, a systematic review and meta-analysis |
| title_fullStr | Platelet count and retinopathy of prematurity, a systematic review and meta-analysis |
| title_full_unstemmed | Platelet count and retinopathy of prematurity, a systematic review and meta-analysis |
| title_short | Platelet count and retinopathy of prematurity, a systematic review and meta-analysis |
| title_sort | platelet count and retinopathy of prematurity a systematic review and meta analysis |
| topic | platelet count retinopathy of premature ROP premature meta-analysis |
| url | https://www.frontiersin.org/articles/10.3389/fped.2024.1413271/full |
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