Immune checkpoint blockade therapy mitigates systemic inflammation and affects cellular FLIP-expressing monocytic myeloid-derived suppressor cells in non-progressor non-small cell lung cancer patients

Immune checkpoint blockade therapy mitigates systemic inflammation and affects cellular FLIP-expressing monocytic myeloid-derived suppressor cells in non-progressor non-small cell lung cancer patients

Cancer cells favor the generation of myeloid cells with immunosuppressive and inflammatory features, including myeloid-derived suppressor cells (MDSCs), which support tumor progression. The anti-apoptotic molecule, cellular FLICE (FADD-like interleukin-1β-converting enzyme)-inhibitory protein (c-FLI...

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Main Authors: Annalisa Adamo, Cristina Frusteri, Sara Pilotto, Simone Caligola, Lorenzo Belluomini, Ornella Poffe, Luca Giacobazzi, Silvia Dusi, Chiara Musiu, Yushu Hu, Tian Wang, Davide Rizzini, Antonio Vella, Stefania Canè, Giulia Sartori, Jessica Insolda, Marco Sposito, Ursula Cesta Incani, Carmine Carbone, Geny Piro, Francesca Pettinella, Fang Qi, Dali Wang, Silvia Sartoris, Francesco De Sanctis, Patrizia Scapini, Stefano Dusi, Marco Antonio Cassatella, Emilio Bria, Michele Milella, Vincenzo Bronte, Stefano Ugel
Format: Article
Language:English
Published: Taylor & Francis Group 2023-12-01
Series:OncoImmunology
Subjects:
NSCLC (non-small cell lung cancer)
M-MDSCs (monocytic myeloid-derived suppressor cells), c-FLIP (cellular FLICE [FADD-like IL-1β-converting enzyme]- inhibitory protein)
ICI (immune checkpoint inhibitor)
Online Access:https://www.tandfonline.com/doi/10.1080/2162402X.2023.2253644
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