Personalized circulating tumor DNA analysis for sensitive disease monitoring and detection of relapse in neuroblastoma

Personalized circulating tumor DNA analysis for sensitive disease monitoring and detection of relapse in neuroblastoma

Abstract Circulating tumor DNA (ctDNA) has shown potential as a non-invasive tumor biomarker in neuroblastoma. Previous studies used generic assays for detection of selected predefined oncogenic variants as markers of ctDNA, which limits the sensitivity and excludes a subset of patients from analysi...

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Main Authors: Ida Rahmqvist, Enya Engström, Elisabeth Mellström, Raghda R. Ibrahim, Fani Pujol-Calderón, Agnes Dahlstrand Rudin, Anna Ordqvist Redfors, Niki Rostamzadeh, Rita Di Rienzo, Wilma Franssila, Robert Khashan, Moe Xylander, Christin Karlsson, Torben Ek, Daniel Andersson, Tobias Österlund, Jennie Gaarder, Henrik Fagman, Susanne Fransson, Tommy Martinsson, Anders Ståhlberg, Martin Dalin
Format: Article
Language:English
Published: BMC 2024-11-01
Series:Biomarker Research
Subjects:
Circulating tumor DNA
Neuroblastoma
Pediatric cancer
Liquid biopsy
Personalized medicine
Online Access:https://doi.org/10.1186/s40364-024-00688-5
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