Drug-drug interactions in hospitalized older adults with acute coronary syndrome – a real-world study in Brazil
Objective: Our aim was to determine the frequency of drug-drug interactions in clinical practice among hospitalized older adults diagnosed with acute coronary syndrome. Methods: This cross-sectional and descriptive study included 119 older adults with acute coronary syndrome who were admitted to a B...
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| Format: | Article |
| Language: | English |
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Brazilian Society of Geriatrics and Gerontology
2025-01-01
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| Series: | Geriatrics, Gerontology and Aging |
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| Online Access: | https://cdn.publisher.gn1.link/ggaging.com/pdf/v18225.pdf |
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| _version_ | 1841553200618930176 |
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| author | Tiago Aparecido Maschio de Lima Moacir Fernandes de Godoy |
| author_facet | Tiago Aparecido Maschio de Lima Moacir Fernandes de Godoy |
| author_sort | Tiago Aparecido Maschio de Lima |
| collection | DOAJ |
| description | Objective: Our aim was to determine the frequency of drug-drug interactions in clinical practice among hospitalized older adults diagnosed with acute coronary syndrome. Methods: This cross-sectional and descriptive study included 119 older adults with acute coronary syndrome who were admitted to a Brazilian public hospital. Potential drug-drug interactions were identified and classified using computerized databases. Adverse events were characterized according to severity, temporal relationship, causality, interactions as a determining factor, and traceability criteria. Results: Of the total sample, 30.25% of participants had ≥ 1 real drug-drug interaction. A total of 53 real drug-drug interactions were identified. The median number of real drug-drug interactions was 1 (maximum 3) per patient; 5.56% of those who experienced real drug-drug interactions died and 94.44% were discharged from hospital. Of the real drug-drug interactions, 47.17% were moderate and 41.51% were serious. Conclusions: Drug-drug interactions resulted in adverse reactions in hospitalized older adults with acute coronary syndrome in a real-world scenario in Brazil. |
| format | Article |
| id | doaj-art-57f51e30d4df49a7952c1942c9ddd2b1 |
| institution | Kabale University |
| issn | 2447-2123 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Brazilian Society of Geriatrics and Gerontology |
| record_format | Article |
| series | Geriatrics, Gerontology and Aging |
| spelling | doaj-art-57f51e30d4df49a7952c1942c9ddd2b12025-01-09T11:31:04ZengBrazilian Society of Geriatrics and GerontologyGeriatrics, Gerontology and Aging2447-21232025-01-01181910.53886/gga.e0000225_ENDrug-drug interactions in hospitalized older adults with acute coronary syndrome – a real-world study in BrazilTiago Aparecido Maschio de Lima0https://orcid.org/0000-0001-7529-9527Moacir Fernandes de Godoy1https://orcid.org/0000-0001-8390-0933Programa de Pós-Graduação Stricto Sensu em Ciências da Saúde, Faculdade de Medicina de São José do Rio Preto – São José do Rio Preto (SP), Brazil.Programa de Pós-Graduação Stricto Sensu em Ciências da Saúde, Faculdade de Medicina de São José do Rio Preto – São José do Rio Preto (SP), Brazil.Objective: Our aim was to determine the frequency of drug-drug interactions in clinical practice among hospitalized older adults diagnosed with acute coronary syndrome. Methods: This cross-sectional and descriptive study included 119 older adults with acute coronary syndrome who were admitted to a Brazilian public hospital. Potential drug-drug interactions were identified and classified using computerized databases. Adverse events were characterized according to severity, temporal relationship, causality, interactions as a determining factor, and traceability criteria. Results: Of the total sample, 30.25% of participants had ≥ 1 real drug-drug interaction. A total of 53 real drug-drug interactions were identified. The median number of real drug-drug interactions was 1 (maximum 3) per patient; 5.56% of those who experienced real drug-drug interactions died and 94.44% were discharged from hospital. Of the real drug-drug interactions, 47.17% were moderate and 41.51% were serious. Conclusions: Drug-drug interactions resulted in adverse reactions in hospitalized older adults with acute coronary syndrome in a real-world scenario in Brazil.https://cdn.publisher.gn1.link/ggaging.com/pdf/v18225.pdfolder adultsacute coronary syndromedrug-drug interactionshospital |
| spellingShingle | Tiago Aparecido Maschio de Lima Moacir Fernandes de Godoy Drug-drug interactions in hospitalized older adults with acute coronary syndrome – a real-world study in Brazil Geriatrics, Gerontology and Aging older adults acute coronary syndrome drug-drug interactions hospital |
| title | Drug-drug interactions in hospitalized older adults with acute coronary syndrome – a real-world study in Brazil |
| title_full | Drug-drug interactions in hospitalized older adults with acute coronary syndrome – a real-world study in Brazil |
| title_fullStr | Drug-drug interactions in hospitalized older adults with acute coronary syndrome – a real-world study in Brazil |
| title_full_unstemmed | Drug-drug interactions in hospitalized older adults with acute coronary syndrome – a real-world study in Brazil |
| title_short | Drug-drug interactions in hospitalized older adults with acute coronary syndrome – a real-world study in Brazil |
| title_sort | drug drug interactions in hospitalized older adults with acute coronary syndrome a real world study in brazil |
| topic | older adults acute coronary syndrome drug-drug interactions hospital |
| url | https://cdn.publisher.gn1.link/ggaging.com/pdf/v18225.pdf |
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