EFFECT OF THE EXTENT OF MEDIASTINAL LYMPHODISSECTION ON THE RESULTS OF COMBINED MODALITY TREATMENT FOR STAGE IIIA (N2 ) NON-SMALL CELL LUNG CANCER
Short-and long-term results of combined modality treatment with systematic (n=60) and selective (n=51) mediastinal lymphodissection were compared in 111 patients with IIIA(N2 ) stage non-small lung cancer taking into account the tumor site, histological pattern of the tumor and the extent of radical...
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| Format: | Article |
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Russian Academy of Sciences, Tomsk National Research Medical Center
2016-02-01
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| Series: | Сибирский онкологический журнал |
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| Online Access: | https://www.siboncoj.ru/jour/article/view/211 |
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| author | E. O. Mantsyrev A. V. Vazhenin O. A. Gladkov A. A. Lukin M. N. Mironchenko Ya. A. Gnatyuk S. N. Timofeev |
| author_facet | E. O. Mantsyrev A. V. Vazhenin O. A. Gladkov A. A. Lukin M. N. Mironchenko Ya. A. Gnatyuk S. N. Timofeev |
| author_sort | E. O. Mantsyrev |
| collection | DOAJ |
| description | Short-and long-term results of combined modality treatment with systematic (n=60) and selective (n=51) mediastinal lymphodissection were compared in 111 patients with IIIA(N2 ) stage non-small lung cancer taking into account the tumor site, histological pattern of the tumor and the extent of radical surgery. The recurrence-free survival rate was significantly higher in patients with squamous cell lung cancer who underwent systematic lymphodissection than in patients who underwent selective lymphodissection. The median disease progression-free survival was 31 months and 14.5 months and the overall 5-year survival rates were 43,4 % and 16 %, respectively (p<0,05). A significant increase in recurrence-free and overall 5-year survival rates was observed in group I patients with cancer of the left lung as compared to that observed in group II patients. Selective mediastinal lymphodissection may be the operation of choice in patients with stage IIIA(N2 ) non-small cell lung cancer and in patients with cancer of the right lung who received combined modality treatment including adjuvant radiation therapy. |
| format | Article |
| id | doaj-art-57f35e7afda943ca885511b6329fca52 |
| institution | Kabale University |
| issn | 1814-4861 2312-3168 |
| language | Russian |
| publishDate | 2016-02-01 |
| publisher | Russian Academy of Sciences, Tomsk National Research Medical Center |
| record_format | Article |
| series | Сибирский онкологический журнал |
| spelling | doaj-art-57f35e7afda943ca885511b6329fca522025-08-20T03:56:24ZrusRussian Academy of Sciences, Tomsk National Research Medical CenterСибирский онкологический журнал1814-48612312-31682016-02-01051216211EFFECT OF THE EXTENT OF MEDIASTINAL LYMPHODISSECTION ON THE RESULTS OF COMBINED MODALITY TREATMENT FOR STAGE IIIA (N2 ) NON-SMALL CELL LUNG CANCERE. O. Mantsyrev0A. V. Vazhenin1O. A. Gladkov2A. A. Lukin3M. N. Mironchenko4Ya. A. Gnatyuk5S. N. Timofeev6Chelyabinsk Regional Clinical Oncology Center, ChelyabinskChelyabinsk Regional Clinical Oncology Center, ChelyabinskChelyabinsk Regional Clinical Oncology Center, ChelyabinskChelyabinsk Regional Clinical Oncology Center, ChelyabinskChelyabinsk Regional Clinical Oncology Center, ChelyabinskChelyabinsk Regional Clinical Oncology Center, ChelyabinskChelyabinsk Regional Clinical Oncology Center, ChelyabinskShort-and long-term results of combined modality treatment with systematic (n=60) and selective (n=51) mediastinal lymphodissection were compared in 111 patients with IIIA(N2 ) stage non-small lung cancer taking into account the tumor site, histological pattern of the tumor and the extent of radical surgery. The recurrence-free survival rate was significantly higher in patients with squamous cell lung cancer who underwent systematic lymphodissection than in patients who underwent selective lymphodissection. The median disease progression-free survival was 31 months and 14.5 months and the overall 5-year survival rates were 43,4 % and 16 %, respectively (p<0,05). A significant increase in recurrence-free and overall 5-year survival rates was observed in group I patients with cancer of the left lung as compared to that observed in group II patients. Selective mediastinal lymphodissection may be the operation of choice in patients with stage IIIA(N2 ) non-small cell lung cancer and in patients with cancer of the right lung who received combined modality treatment including adjuvant radiation therapy.https://www.siboncoj.ru/jour/article/view/211non-small cell lung cancerselective mediastinal lymphodissectionsystematic mediastinal lymphodissectioncombined modality treatment |
| spellingShingle | E. O. Mantsyrev A. V. Vazhenin O. A. Gladkov A. A. Lukin M. N. Mironchenko Ya. A. Gnatyuk S. N. Timofeev EFFECT OF THE EXTENT OF MEDIASTINAL LYMPHODISSECTION ON THE RESULTS OF COMBINED MODALITY TREATMENT FOR STAGE IIIA (N2 ) NON-SMALL CELL LUNG CANCER Сибирский онкологический журнал non-small cell lung cancer selective mediastinal lymphodissection systematic mediastinal lymphodissection combined modality treatment |
| title | EFFECT OF THE EXTENT OF MEDIASTINAL LYMPHODISSECTION ON THE RESULTS OF COMBINED MODALITY TREATMENT FOR STAGE IIIA (N2 ) NON-SMALL CELL LUNG CANCER |
| title_full | EFFECT OF THE EXTENT OF MEDIASTINAL LYMPHODISSECTION ON THE RESULTS OF COMBINED MODALITY TREATMENT FOR STAGE IIIA (N2 ) NON-SMALL CELL LUNG CANCER |
| title_fullStr | EFFECT OF THE EXTENT OF MEDIASTINAL LYMPHODISSECTION ON THE RESULTS OF COMBINED MODALITY TREATMENT FOR STAGE IIIA (N2 ) NON-SMALL CELL LUNG CANCER |
| title_full_unstemmed | EFFECT OF THE EXTENT OF MEDIASTINAL LYMPHODISSECTION ON THE RESULTS OF COMBINED MODALITY TREATMENT FOR STAGE IIIA (N2 ) NON-SMALL CELL LUNG CANCER |
| title_short | EFFECT OF THE EXTENT OF MEDIASTINAL LYMPHODISSECTION ON THE RESULTS OF COMBINED MODALITY TREATMENT FOR STAGE IIIA (N2 ) NON-SMALL CELL LUNG CANCER |
| title_sort | effect of the extent of mediastinal lymphodissection on the results of combined modality treatment for stage iiia n2 non small cell lung cancer |
| topic | non-small cell lung cancer selective mediastinal lymphodissection systematic mediastinal lymphodissection combined modality treatment |
| url | https://www.siboncoj.ru/jour/article/view/211 |
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