Cerebrolysin in Patients Diagnosed with Subarachnoid Hemorrhage—The Results of an Observational Cohort Study
<b>Background:</b> Subarachnoid hemorrhage (SAH) is associated with high mortality and a high level of disability. Progress in surgical and endovascular techniques has lowered the mortality rate in patients with SAH. However, many patients are left with neurological impairment. <b>...
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2024-10-01
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| author | Klaudyna Kojder Konrad Jarosz Agata Andrzejewska Joanna Solek-Pastuszka Karolina Skonieczna-Żydecka Mariusz Kaczmarczyk Anna Jurczak |
| author_facet | Klaudyna Kojder Konrad Jarosz Agata Andrzejewska Joanna Solek-Pastuszka Karolina Skonieczna-Żydecka Mariusz Kaczmarczyk Anna Jurczak |
| author_sort | Klaudyna Kojder |
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| description | <b>Background:</b> Subarachnoid hemorrhage (SAH) is associated with high mortality and a high level of disability. Progress in surgical and endovascular techniques has lowered the mortality rate in patients with SAH. However, many patients are left with neurological impairment. <b>Objectives:</b> In our study we wanted to examine the impact of Cerebrolysin on treatment results in patients with SAH diagnosis. <b>Methods:</b> The data of 47 patients, divided into Cerebrolysin (26) and non-Cerebrolysin (21) group were included. We examined the correlation between Cerebrolysin administration and additional Amantadine treatment or neuromonitoring, craniectomy, and endovascular treatment and its impact on the Glasgow Outcome Scale (GOS) score, length of stay (LOS), and mortality. <b>Results:</b> Our study shows that Cerebrolysin improves the mortality rate in combination with neuromonitoring in a group of patients with severe SAH. It does not affect the raw values of GOS or LOS in patients with SAH. <b>Conclusions:</b> Further studies with larger patient groups are needed to investigate the role of Cerebrolysin as an additional treatment in SAH. |
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| institution | Kabale University |
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| language | English |
| publishDate | 2024-10-01 |
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| series | Biomedicines |
| spelling | doaj-art-57eef80fb6da45da8a0d89498e9f2ee92024-11-26T17:52:59ZengMDPI AGBiomedicines2227-90592024-10-011211249210.3390/biomedicines12112492Cerebrolysin in Patients Diagnosed with Subarachnoid Hemorrhage—The Results of an Observational Cohort StudyKlaudyna Kojder0Konrad Jarosz1Agata Andrzejewska2Joanna Solek-Pastuszka3Karolina Skonieczna-Żydecka4Mariusz Kaczmarczyk5Anna Jurczak6Anesthesiology and Intensive Care Department, Pomeranian Medical University, Rybacka 1 str., 70-204 Szczecin, PolandAnesthesiology and Intensive Care Department, Pomeranian Medical University, Rybacka 1 str., 70-204 Szczecin, PolandAnesthesiology and Intensive Care Department, Pomeranian Medical University, Rybacka 1 str., 70-204 Szczecin, PolandAnesthesiology and Intensive Care Department, Pomeranian Medical University, Rybacka 1 str., 70-204 Szczecin, PolandDepartment of Biochemical Science, Pomeranian Medical University in Szczecin, Broniewskiego 24, 71-460 Szczecin, PolandDepartment of Biochemical Science, Pomeranian Medical University in Szczecin, Broniewskiego 24, 71-460 Szczecin, PolandDepartment of Specialist Nursery, Pomeranian Medical University, Zolnierska Str. 48, 71-210 Szczecin, Poland<b>Background:</b> Subarachnoid hemorrhage (SAH) is associated with high mortality and a high level of disability. Progress in surgical and endovascular techniques has lowered the mortality rate in patients with SAH. However, many patients are left with neurological impairment. <b>Objectives:</b> In our study we wanted to examine the impact of Cerebrolysin on treatment results in patients with SAH diagnosis. <b>Methods:</b> The data of 47 patients, divided into Cerebrolysin (26) and non-Cerebrolysin (21) group were included. We examined the correlation between Cerebrolysin administration and additional Amantadine treatment or neuromonitoring, craniectomy, and endovascular treatment and its impact on the Glasgow Outcome Scale (GOS) score, length of stay (LOS), and mortality. <b>Results:</b> Our study shows that Cerebrolysin improves the mortality rate in combination with neuromonitoring in a group of patients with severe SAH. It does not affect the raw values of GOS or LOS in patients with SAH. <b>Conclusions:</b> Further studies with larger patient groups are needed to investigate the role of Cerebrolysin as an additional treatment in SAH.https://www.mdpi.com/2227-9059/12/11/2492SAHCerebrolysinneuromonitoring |
| spellingShingle | Klaudyna Kojder Konrad Jarosz Agata Andrzejewska Joanna Solek-Pastuszka Karolina Skonieczna-Żydecka Mariusz Kaczmarczyk Anna Jurczak Cerebrolysin in Patients Diagnosed with Subarachnoid Hemorrhage—The Results of an Observational Cohort Study Biomedicines SAH Cerebrolysin neuromonitoring |
| title | Cerebrolysin in Patients Diagnosed with Subarachnoid Hemorrhage—The Results of an Observational Cohort Study |
| title_full | Cerebrolysin in Patients Diagnosed with Subarachnoid Hemorrhage—The Results of an Observational Cohort Study |
| title_fullStr | Cerebrolysin in Patients Diagnosed with Subarachnoid Hemorrhage—The Results of an Observational Cohort Study |
| title_full_unstemmed | Cerebrolysin in Patients Diagnosed with Subarachnoid Hemorrhage—The Results of an Observational Cohort Study |
| title_short | Cerebrolysin in Patients Diagnosed with Subarachnoid Hemorrhage—The Results of an Observational Cohort Study |
| title_sort | cerebrolysin in patients diagnosed with subarachnoid hemorrhage the results of an observational cohort study |
| topic | SAH Cerebrolysin neuromonitoring |
| url | https://www.mdpi.com/2227-9059/12/11/2492 |
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