Novosorb® BTM- history, production and application in challenging wounds
Novosorb® Biodegradable Temporising Matrix (BTM) is an entirely synthetic dermal matrix that is gaining popularity in the management of challenging wounds. Not only does it provide a framework in which to grow an organised neodermis, it is also especially resistant to infection. Today, the matrix is...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-11-01
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| Series: | Frontiers in Bioengineering and Biotechnology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fbioe.2024.1450973/full |
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| author | Rohan Rajaram Min Zhang Gehan Premaratne Gehan Premaratne Sally Ng Sally Ng |
| author_facet | Rohan Rajaram Min Zhang Gehan Premaratne Gehan Premaratne Sally Ng Sally Ng |
| author_sort | Rohan Rajaram |
| collection | DOAJ |
| description | Novosorb® Biodegradable Temporising Matrix (BTM) is an entirely synthetic dermal matrix that is gaining popularity in the management of challenging wounds. Not only does it provide a framework in which to grow an organised neodermis, it is also especially resistant to infection. Today, the matrix is available as a 2 mm thick open cell polyurethane foam with a non-degrading sealing membrane. Its current form is the result of numerous in vitro and in vivo experiments that examined its shape, biodegradation, inflammatory response, and cytotoxicity. Clinical data on the use of BTM in a variety of cases is novel and presents early insights into its ability to foster wound healing where otherwise improbable. This review presents the history and development of Novosorb® BTM as well as all the currently available clinical data on its efficacy in difficult wounds such as: major burns, necrotising soft tissue infection, chronic wounds and in non graftable wound beds. |
| format | Article |
| id | doaj-art-57c972e2c6b94ddf8b532542a6d90bc7 |
| institution | Kabale University |
| issn | 2296-4185 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj-art-57c972e2c6b94ddf8b532542a6d90bc72024-11-20T10:20:02ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852024-11-011210.3389/fbioe.2024.14509731450973Novosorb® BTM- history, production and application in challenging woundsRohan Rajaram0Min Zhang1Gehan Premaratne2Gehan Premaratne3Sally Ng4Sally Ng5Department of Plastic and Reconstructive Surgery, Austin Health, Heidelberg, VIC, AustraliaDepartment of Plastic and Reconstructive Surgery, Austin Health, Heidelberg, VIC, AustraliaDepartment of Plastic and Reconstructive Surgery, Austin Health, Heidelberg, VIC, AustraliaDepartment of Medicine, Dentistry and Health Sciences, The University of Melbourne, Melbourne, VIC, AustraliaDepartment of Plastic and Reconstructive Surgery, Austin Health, Heidelberg, VIC, AustraliaDepartment of Surgery (Austin Precinct), The University of Melbourne, VIC, AustraliaNovosorb® Biodegradable Temporising Matrix (BTM) is an entirely synthetic dermal matrix that is gaining popularity in the management of challenging wounds. Not only does it provide a framework in which to grow an organised neodermis, it is also especially resistant to infection. Today, the matrix is available as a 2 mm thick open cell polyurethane foam with a non-degrading sealing membrane. Its current form is the result of numerous in vitro and in vivo experiments that examined its shape, biodegradation, inflammatory response, and cytotoxicity. Clinical data on the use of BTM in a variety of cases is novel and presents early insights into its ability to foster wound healing where otherwise improbable. This review presents the history and development of Novosorb® BTM as well as all the currently available clinical data on its efficacy in difficult wounds such as: major burns, necrotising soft tissue infection, chronic wounds and in non graftable wound beds.https://www.frontiersin.org/articles/10.3389/fbioe.2024.1450973/fullbiodegradable temporising matrix (BTM)burnsplastic and reconstructive surgery (PRS)necrotising fasciitischronic ulcer |
| spellingShingle | Rohan Rajaram Min Zhang Gehan Premaratne Gehan Premaratne Sally Ng Sally Ng Novosorb® BTM- history, production and application in challenging wounds Frontiers in Bioengineering and Biotechnology biodegradable temporising matrix (BTM) burns plastic and reconstructive surgery (PRS) necrotising fasciitis chronic ulcer |
| title | Novosorb® BTM- history, production and application in challenging wounds |
| title_full | Novosorb® BTM- history, production and application in challenging wounds |
| title_fullStr | Novosorb® BTM- history, production and application in challenging wounds |
| title_full_unstemmed | Novosorb® BTM- history, production and application in challenging wounds |
| title_short | Novosorb® BTM- history, production and application in challenging wounds |
| title_sort | novosorb r btm history production and application in challenging wounds |
| topic | biodegradable temporising matrix (BTM) burns plastic and reconstructive surgery (PRS) necrotising fasciitis chronic ulcer |
| url | https://www.frontiersin.org/articles/10.3389/fbioe.2024.1450973/full |
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