Incidence of HIV and HCV in people who inject drugs: a systematic and meta-analysis review protocol
Introduction HIV and hepatitis C virus (HCV) are major health concerns globally. This systematic review and meta-analysis protocol study aims to estimate the incidence of HIV and HCV among people who inject drugs (PWIDs) by reviewing studies that have applied mathematical modelling. The primary purp...
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BMJ Publishing Group
2021-01-01
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| Series: | BMJ Open |
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| author | Azam Rahmani Zahra Jorjoran Shushtari Asaad Sharhani Bahram Armoon Mehdi Noroozi Elaheh Ahounbar Salah Eddin Karimi Peter Higgs |
| author_facet | Azam Rahmani Zahra Jorjoran Shushtari Asaad Sharhani Bahram Armoon Mehdi Noroozi Elaheh Ahounbar Salah Eddin Karimi Peter Higgs |
| author_sort | Azam Rahmani |
| collection | DOAJ |
| description | Introduction HIV and hepatitis C virus (HCV) are major health concerns globally. This systematic review and meta-analysis protocol study aims to estimate the incidence of HIV and HCV among people who inject drugs (PWIDs) by reviewing studies that have applied mathematical modelling. The primary purpose of this systematic review is to identify and review mathematical modelling studies of HIV and HCV incidence in PWIDs.Methods and analysis cohort, cross-sectional and clinical trial studies conducted to estimate the incidence of HIV and HCV based on mathematical models or have evaluated the effectiveness of mathematical models will be considered for inclusion in the review. A comprehensive search applying a Cochrane approach will be used to identify relevant primary studies, published between January 2000 and July 2020, and indexed in PubMed, EMBASE, Opengrey, WOS, SCOPUS and Cochrane Library with no restriction on language. This protocol was prepared according to the Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols (PRISMA-P). Study selection and data extraction will be performed by two independent reviewers. Assessment of risk of bias will be implemented using forms of the Critical Appraisal Skills Programme. Publication bias will be assessed by funnel plots, Begg’s and Egger’s tests. A meta-analysis will be conducted to answer the first research question, ‘What is the incidence of HIV and HCV when applying mathematical model in PWID?’. Clinical heterogeneity will be assessed by looking at the characteristics of participants, method of diagnosis and case definitions in the included primary studies. In addition, subgroup analyses will be conducted for population and secondary outcomes.Ethics and dissemination There are no ethical issues related to this study. The findings will be published in peer-reviewed scientific journals and presented at international and national conferences.PROSPERO registration number CRD42019126476. |
| format | Article |
| id | doaj-art-57c8d3a446974129b62f57940c7d15f4 |
| institution | Kabale University |
| issn | 2044-6055 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj-art-57c8d3a446974129b62f57940c7d15f42024-11-18T13:25:13ZengBMJ Publishing GroupBMJ Open2044-60552021-01-0111110.1136/bmjopen-2020-041482Incidence of HIV and HCV in people who inject drugs: a systematic and meta-analysis review protocolAzam Rahmani0Zahra Jorjoran Shushtari1Asaad Sharhani2Bahram Armoon3Mehdi Noroozi4Elaheh Ahounbar5Salah Eddin Karimi6Peter Higgs7Nursing and Midwifery Care Research Center, School of Nursing and Midwifery, Tehran University of Medical Sciences, Tehran, IranSocial Determinants of Health Research Center, University of Social Welfare and Rehabilitation Sciences, Tehran, IranDepartment of Epidemiology and Biostatistics, Public Health Faculty, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IranSocial Determinants of Health Research Center, Saveh University of Medical Sciences, Saveh, IranSocial Determinants of Health Research Center, University of Social Welfare and Rehabilitation Sciences, Tehran, IranSubstance Abuse and Dependence Research Center, University of Social Welfare and Rehabilitation Sciences, Tehran, IranSocial Determinants of Health Research Center, Health Management and Safety Promotion Research Institute, Tabriz University of Medical Sciences, Tabriz, IranDepartment of Public Health, La Trobe University, Plenty Rd & Kingsbury Dr, Bundoora, VIC 3086, La Trobe University, Melbourne, Victoria, AustraliaIntroduction HIV and hepatitis C virus (HCV) are major health concerns globally. This systematic review and meta-analysis protocol study aims to estimate the incidence of HIV and HCV among people who inject drugs (PWIDs) by reviewing studies that have applied mathematical modelling. The primary purpose of this systematic review is to identify and review mathematical modelling studies of HIV and HCV incidence in PWIDs.Methods and analysis cohort, cross-sectional and clinical trial studies conducted to estimate the incidence of HIV and HCV based on mathematical models or have evaluated the effectiveness of mathematical models will be considered for inclusion in the review. A comprehensive search applying a Cochrane approach will be used to identify relevant primary studies, published between January 2000 and July 2020, and indexed in PubMed, EMBASE, Opengrey, WOS, SCOPUS and Cochrane Library with no restriction on language. This protocol was prepared according to the Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols (PRISMA-P). Study selection and data extraction will be performed by two independent reviewers. Assessment of risk of bias will be implemented using forms of the Critical Appraisal Skills Programme. Publication bias will be assessed by funnel plots, Begg’s and Egger’s tests. A meta-analysis will be conducted to answer the first research question, ‘What is the incidence of HIV and HCV when applying mathematical model in PWID?’. Clinical heterogeneity will be assessed by looking at the characteristics of participants, method of diagnosis and case definitions in the included primary studies. In addition, subgroup analyses will be conducted for population and secondary outcomes.Ethics and dissemination There are no ethical issues related to this study. The findings will be published in peer-reviewed scientific journals and presented at international and national conferences.PROSPERO registration number CRD42019126476.https://bmjopen.bmj.com/content/11/1/e041482.full |
| spellingShingle | Azam Rahmani Zahra Jorjoran Shushtari Asaad Sharhani Bahram Armoon Mehdi Noroozi Elaheh Ahounbar Salah Eddin Karimi Peter Higgs Incidence of HIV and HCV in people who inject drugs: a systematic and meta-analysis review protocol BMJ Open |
| title | Incidence of HIV and HCV in people who inject drugs: a systematic and meta-analysis review protocol |
| title_full | Incidence of HIV and HCV in people who inject drugs: a systematic and meta-analysis review protocol |
| title_fullStr | Incidence of HIV and HCV in people who inject drugs: a systematic and meta-analysis review protocol |
| title_full_unstemmed | Incidence of HIV and HCV in people who inject drugs: a systematic and meta-analysis review protocol |
| title_short | Incidence of HIV and HCV in people who inject drugs: a systematic and meta-analysis review protocol |
| title_sort | incidence of hiv and hcv in people who inject drugs a systematic and meta analysis review protocol |
| url | https://bmjopen.bmj.com/content/11/1/e041482.full |
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