Optic nerve sheath diameter/eyeball transverse diameter ratio by ultrasound in prediction of increased intracranial pressure in children with viral encephalitis
IntroductionIncreased intracranial pressure (ICP) is common with viral encephalitis in children which is associated with complications and prognosis. The optic nerve sheath diameter (ONSD) is a new indicator for the assessment of intracranial pressure using ultrasound, CT scan and MRI imaging. Given...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Pediatrics |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fped.2024.1485107/full |
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| author | Chun Zhao Peng-Cheng Sun Ke-Jie Fang Hui-Hui Fu Li-Feng Wei Yin-Yun Miao Xin-Xin Guo Xiao-Ling Weng |
| author_facet | Chun Zhao Peng-Cheng Sun Ke-Jie Fang Hui-Hui Fu Li-Feng Wei Yin-Yun Miao Xin-Xin Guo Xiao-Ling Weng |
| author_sort | Chun Zhao |
| collection | DOAJ |
| description | IntroductionIncreased intracranial pressure (ICP) is common with viral encephalitis in children which is associated with complications and prognosis. The optic nerve sheath diameter (ONSD) is a new indicator for the assessment of intracranial pressure using ultrasound, CT scan and MRI imaging. Given the influence of physical development on ONSD size in children, we expect more accurate assessment of intracranial pressure with ONSD/ETD (eyeball transverse diameter) ratio by ultrasound. The aim of the study is to determine the performance of the ONSD/ETD ratio measurement to predict ICP occurring in children with viral encephalitis and evaluate the therapeutic effect.MethodsChildren with viral encephalitis from May 2022 to June 2024 were recruited in this study. The initial ONSD/ETD ratio measurement by ultrasound were completed before lumbar puncture. Children were divided into the increased ICP group and the normal ICP group based on whether the ICP was over 200 mmH2O measured by lumbar puncture. The ultrasound was repeated on the 3rd and 7th day of treatment.ResultsThe ONSD/ETD ratios measured in the two groups before treatment were 0.231 ± 0.019 and 0.182 ± 0.012, respectively (p < 0.01). The ONSD/ETD ratio on the 3rd day of treatment in the increased ICP group was significantly lower than the data before treatment (p < 0.01). The data on the 7th day of treatment in increased ICP group was significantly lower than the data before treatment (p < 0.01), but not statistically significant compared to the data on the 3rd day of treatment (p = 0.650). The ROC curve demonstrated an AUC for ONSD/ETD ratio in predicting the occurrence of increased ICP in children with viral encephalitis was 0.974 [95% confidence interval (CI): 0.939–1.000, p < 0.01], with a sensitivity of 95.1% and specificity of 93.3% at a cut-off value of 0.198.ConclusionOur study shows that ONSD/ETD can be used as an easy reference tool for evaluating ICP in children with viral encephalitis which can reflect the therapeutic effect. |
| format | Article |
| id | doaj-art-57abab05fb75490f8188f6aa1d21e99d |
| institution | Kabale University |
| issn | 2296-2360 |
| language | English |
| publishDate | 2025-01-01 |
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| series | Frontiers in Pediatrics |
| spelling | doaj-art-57abab05fb75490f8188f6aa1d21e99d2025-01-07T06:45:29ZengFrontiers Media S.A.Frontiers in Pediatrics2296-23602025-01-011210.3389/fped.2024.14851071485107Optic nerve sheath diameter/eyeball transverse diameter ratio by ultrasound in prediction of increased intracranial pressure in children with viral encephalitisChun Zhao0Peng-Cheng Sun1Ke-Jie Fang2Hui-Hui Fu3Li-Feng Wei4Yin-Yun Miao5Xin-Xin Guo6Xiao-Ling Weng7Department of Pediatrics, The Affiliated Yangming Hospital of Ningbo University, Yuyao People’s Hospital, Yuyao Branch of the Second Affiliated Hospital of Zhejiang University School of Medicine, Ningbo, ChinaDepartment of Ultrasound, The Affiliated Yangming Hospital of Ningbo University, Yuyao People’s Hospital, Yuyao Branch of the Second Affiliated Hospital of Zhejiang University School of Medicine, Ningbo, ChinaDepartment of Medical Imaging, Ditang Central Health Center, Yuyao People’s Hospital Medical Community, Ningbo, ChinaDepartment of Pediatrics, The Affiliated Yangming Hospital of Ningbo University, Yuyao People’s Hospital, Yuyao Branch of the Second Affiliated Hospital of Zhejiang University School of Medicine, Ningbo, ChinaDepartment of Pediatrics, The Affiliated Yangming Hospital of Ningbo University, Yuyao People’s Hospital, Yuyao Branch of the Second Affiliated Hospital of Zhejiang University School of Medicine, Ningbo, ChinaDepartment of Pediatrics, The Affiliated Yangming Hospital of Ningbo University, Yuyao People’s Hospital, Yuyao Branch of the Second Affiliated Hospital of Zhejiang University School of Medicine, Ningbo, ChinaDepartment of Pediatrics, The Affiliated Yangming Hospital of Ningbo University, Yuyao People’s Hospital, Yuyao Branch of the Second Affiliated Hospital of Zhejiang University School of Medicine, Ningbo, ChinaDepartment of Pediatrics, The Affiliated Yangming Hospital of Ningbo University, Yuyao People’s Hospital, Yuyao Branch of the Second Affiliated Hospital of Zhejiang University School of Medicine, Ningbo, ChinaIntroductionIncreased intracranial pressure (ICP) is common with viral encephalitis in children which is associated with complications and prognosis. The optic nerve sheath diameter (ONSD) is a new indicator for the assessment of intracranial pressure using ultrasound, CT scan and MRI imaging. Given the influence of physical development on ONSD size in children, we expect more accurate assessment of intracranial pressure with ONSD/ETD (eyeball transverse diameter) ratio by ultrasound. The aim of the study is to determine the performance of the ONSD/ETD ratio measurement to predict ICP occurring in children with viral encephalitis and evaluate the therapeutic effect.MethodsChildren with viral encephalitis from May 2022 to June 2024 were recruited in this study. The initial ONSD/ETD ratio measurement by ultrasound were completed before lumbar puncture. Children were divided into the increased ICP group and the normal ICP group based on whether the ICP was over 200 mmH2O measured by lumbar puncture. The ultrasound was repeated on the 3rd and 7th day of treatment.ResultsThe ONSD/ETD ratios measured in the two groups before treatment were 0.231 ± 0.019 and 0.182 ± 0.012, respectively (p < 0.01). The ONSD/ETD ratio on the 3rd day of treatment in the increased ICP group was significantly lower than the data before treatment (p < 0.01). The data on the 7th day of treatment in increased ICP group was significantly lower than the data before treatment (p < 0.01), but not statistically significant compared to the data on the 3rd day of treatment (p = 0.650). The ROC curve demonstrated an AUC for ONSD/ETD ratio in predicting the occurrence of increased ICP in children with viral encephalitis was 0.974 [95% confidence interval (CI): 0.939–1.000, p < 0.01], with a sensitivity of 95.1% and specificity of 93.3% at a cut-off value of 0.198.ConclusionOur study shows that ONSD/ETD can be used as an easy reference tool for evaluating ICP in children with viral encephalitis which can reflect the therapeutic effect.https://www.frontiersin.org/articles/10.3389/fped.2024.1485107/fullpediatricsoptic nerve sheath diameterONSD/ETDincreased intracranial pressureviral encephalitisultrasound |
| spellingShingle | Chun Zhao Peng-Cheng Sun Ke-Jie Fang Hui-Hui Fu Li-Feng Wei Yin-Yun Miao Xin-Xin Guo Xiao-Ling Weng Optic nerve sheath diameter/eyeball transverse diameter ratio by ultrasound in prediction of increased intracranial pressure in children with viral encephalitis Frontiers in Pediatrics pediatrics optic nerve sheath diameter ONSD/ETD increased intracranial pressure viral encephalitis ultrasound |
| title | Optic nerve sheath diameter/eyeball transverse diameter ratio by ultrasound in prediction of increased intracranial pressure in children with viral encephalitis |
| title_full | Optic nerve sheath diameter/eyeball transverse diameter ratio by ultrasound in prediction of increased intracranial pressure in children with viral encephalitis |
| title_fullStr | Optic nerve sheath diameter/eyeball transverse diameter ratio by ultrasound in prediction of increased intracranial pressure in children with viral encephalitis |
| title_full_unstemmed | Optic nerve sheath diameter/eyeball transverse diameter ratio by ultrasound in prediction of increased intracranial pressure in children with viral encephalitis |
| title_short | Optic nerve sheath diameter/eyeball transverse diameter ratio by ultrasound in prediction of increased intracranial pressure in children with viral encephalitis |
| title_sort | optic nerve sheath diameter eyeball transverse diameter ratio by ultrasound in prediction of increased intracranial pressure in children with viral encephalitis |
| topic | pediatrics optic nerve sheath diameter ONSD/ETD increased intracranial pressure viral encephalitis ultrasound |
| url | https://www.frontiersin.org/articles/10.3389/fped.2024.1485107/full |
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