Comprehensive Management of Polycystic Ovary Syndrome: The Role of Metformin in Addressing Metabolic and Endocrine Dysregulation
Background: Polycystic Ovary Syndrome (PCOS) is a prevalent endocrine and metabolic disorder that affects women of reproductive age, characterized by hormonal imbalances, insulin resistance, and a range of clinical manifestations, including infertility and metabolic disturbances. Effective manageme...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Kazimierz Wielki University
2025-01-01
|
| Series: | Journal of Education, Health and Sport |
| Subjects: | |
| Online Access: | https://apcz.umk.pl/JEHS/article/view/57421 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1841554937695174656 |
|---|---|
| author | Martyna Kaźmierczak Jakub Parys Agnieszka Mikosińska Patrycja Kałuziak Marta Jajaczak Maciej Mossakowski Aleksandra Witek Mateusz Litwin Stanisław Jesionek |
| author_facet | Martyna Kaźmierczak Jakub Parys Agnieszka Mikosińska Patrycja Kałuziak Marta Jajaczak Maciej Mossakowski Aleksandra Witek Mateusz Litwin Stanisław Jesionek |
| author_sort | Martyna Kaźmierczak |
| collection | DOAJ |
| description |
Background: Polycystic Ovary Syndrome (PCOS) is a prevalent endocrine and metabolic disorder that affects women of reproductive age, characterized by hormonal imbalances, insulin resistance, and a range of clinical manifestations, including infertility and metabolic disturbances. Effective management of PCOS remains a challenge due to its multifaceted nature, necessitating a comprehensive understanding of therapeutic options.
Aim of the Study: This paper aims to explore the role of various treatment modalities for PCOS, with a particular emphasis on the use of metformin, an antidiabetic medication increasingly recognized for its benefits in managing insulin resistance and other associated conditions in PCOS patients.
Conclusion: The findings highlight metformin's three primary mechanisms of action: enhancing insulin sensitivity, inhibiting hepatic gluconeogenesis, and influencing lipid metabolism. Metformin is effective in improving metabolic parameters and restoring ovulatory function in women with PCOS. While it is a cornerstone of therapy, the management of PCOS requires a tailored approach that considers individual clinical symptoms and phenotypes. Additional therapeutic strategies, including non-pharmacological measures and other pharmacological agents, play a vital role in a comprehensive treatment plan for PCOS.
|
| format | Article |
| id | doaj-art-577f9e81d78c4c61a37c68dceafdfabb |
| institution | Kabale University |
| issn | 2391-8306 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Kazimierz Wielki University |
| record_format | Article |
| series | Journal of Education, Health and Sport |
| spelling | doaj-art-577f9e81d78c4c61a37c68dceafdfabb2025-01-08T08:16:38ZengKazimierz Wielki UniversityJournal of Education, Health and Sport2391-83062025-01-017710.12775/JEHS.2025.77.56421Comprehensive Management of Polycystic Ovary Syndrome: The Role of Metformin in Addressing Metabolic and Endocrine DysregulationMartyna Kaźmierczak0https://orcid.org/0009-0007-7798-0069Jakub Parys1https://orcid.org/0009-0009-1955-7865Agnieszka Mikosińska2https://orcid.org/0009-0003-0891-9089Patrycja Kałuziak3https://orcid.org/0009-0008-0976-1523Marta Jajaczak4https://orcid.org/0009-0009-6000-7769Maciej Mossakowski5https://orcid.org/0009-0008-0423-2083Aleksandra Witek6https://orcid.org/0009-0002-1214-2199Mateusz Litwin7https://orcid.org/0009-0006-5131-1863Stanisław Jesionek8https://orcid.org/0009-0004-6026-702XCentral Clinical Hospital of Medical University of Lodz, ul. Pomorska 251, 92-213 Łódź, PolandCentral Clinical Hospital of Medical University of Lodz, ul. Pomorska 251, 92-213 Łódź, PolandCentral Clinical Hospital of Medical University of Lodz, ul. Pomorska 251, 92-213 Łódź, PolandCharles Jonscher Medical Center, ul. Milionowa 14, 93-113 Łódź, PolandUniversity Clinical Hospital No.2 of Medical University of Lodz, ul. Żeromskiego 113, 90-549 Łódź, PolandCentral Clinical Hospital of Medical University of Lodz, ul. Pomorska 251, 92-213 Łódź, PolandCentral Clinical Hospital of Medical University of Lodz, ul. Pomorska 251, 92-213 Łódź, PolandUniversity Clinical Hospital No.2 of Medical University of Lodz, ul. Żeromskiego 113, 90-549 Łódź, Poland Pabianice Medical Center Sp. o.o., ul. Jana Pawła II 68, 95-200 Pabianice, Poland Background: Polycystic Ovary Syndrome (PCOS) is a prevalent endocrine and metabolic disorder that affects women of reproductive age, characterized by hormonal imbalances, insulin resistance, and a range of clinical manifestations, including infertility and metabolic disturbances. Effective management of PCOS remains a challenge due to its multifaceted nature, necessitating a comprehensive understanding of therapeutic options. Aim of the Study: This paper aims to explore the role of various treatment modalities for PCOS, with a particular emphasis on the use of metformin, an antidiabetic medication increasingly recognized for its benefits in managing insulin resistance and other associated conditions in PCOS patients. Conclusion: The findings highlight metformin's three primary mechanisms of action: enhancing insulin sensitivity, inhibiting hepatic gluconeogenesis, and influencing lipid metabolism. Metformin is effective in improving metabolic parameters and restoring ovulatory function in women with PCOS. While it is a cornerstone of therapy, the management of PCOS requires a tailored approach that considers individual clinical symptoms and phenotypes. Additional therapeutic strategies, including non-pharmacological measures and other pharmacological agents, play a vital role in a comprehensive treatment plan for PCOS. https://apcz.umk.pl/JEHS/article/view/57421Polycystic Ovary Syndrome (PCOS)insulin resistancehyperandrogenismRotterdam criteriametforminlifestyle interventions |
| spellingShingle | Martyna Kaźmierczak Jakub Parys Agnieszka Mikosińska Patrycja Kałuziak Marta Jajaczak Maciej Mossakowski Aleksandra Witek Mateusz Litwin Stanisław Jesionek Comprehensive Management of Polycystic Ovary Syndrome: The Role of Metformin in Addressing Metabolic and Endocrine Dysregulation Journal of Education, Health and Sport Polycystic Ovary Syndrome (PCOS) insulin resistance hyperandrogenism Rotterdam criteria metformin lifestyle interventions |
| title | Comprehensive Management of Polycystic Ovary Syndrome: The Role of Metformin in Addressing Metabolic and Endocrine Dysregulation |
| title_full | Comprehensive Management of Polycystic Ovary Syndrome: The Role of Metformin in Addressing Metabolic and Endocrine Dysregulation |
| title_fullStr | Comprehensive Management of Polycystic Ovary Syndrome: The Role of Metformin in Addressing Metabolic and Endocrine Dysregulation |
| title_full_unstemmed | Comprehensive Management of Polycystic Ovary Syndrome: The Role of Metformin in Addressing Metabolic and Endocrine Dysregulation |
| title_short | Comprehensive Management of Polycystic Ovary Syndrome: The Role of Metformin in Addressing Metabolic and Endocrine Dysregulation |
| title_sort | comprehensive management of polycystic ovary syndrome the role of metformin in addressing metabolic and endocrine dysregulation |
| topic | Polycystic Ovary Syndrome (PCOS) insulin resistance hyperandrogenism Rotterdam criteria metformin lifestyle interventions |
| url | https://apcz.umk.pl/JEHS/article/view/57421 |
| work_keys_str_mv | AT martynakazmierczak comprehensivemanagementofpolycysticovarysyndrometheroleofmetformininaddressingmetabolicandendocrinedysregulation AT jakubparys comprehensivemanagementofpolycysticovarysyndrometheroleofmetformininaddressingmetabolicandendocrinedysregulation AT agnieszkamikosinska comprehensivemanagementofpolycysticovarysyndrometheroleofmetformininaddressingmetabolicandendocrinedysregulation AT patrycjakałuziak comprehensivemanagementofpolycysticovarysyndrometheroleofmetformininaddressingmetabolicandendocrinedysregulation AT martajajaczak comprehensivemanagementofpolycysticovarysyndrometheroleofmetformininaddressingmetabolicandendocrinedysregulation AT maciejmossakowski comprehensivemanagementofpolycysticovarysyndrometheroleofmetformininaddressingmetabolicandendocrinedysregulation AT aleksandrawitek comprehensivemanagementofpolycysticovarysyndrometheroleofmetformininaddressingmetabolicandendocrinedysregulation AT mateuszlitwin comprehensivemanagementofpolycysticovarysyndrometheroleofmetformininaddressingmetabolicandendocrinedysregulation AT stanisławjesionek comprehensivemanagementofpolycysticovarysyndrometheroleofmetformininaddressingmetabolicandendocrinedysregulation |