Enhancing 3D scaffold performance for bone tissue engineering: A comprehensive review of modification and functionalization strategies

Bone tissue engineering holds promise for addressing bone injuries by using biomaterial-based 3D scaffolds. The efficacy of these scaffolds is paramount, relying heavily on their ability to interact with cells and facilitate tissue regeneration. This comprehensive review delves into various modifica...

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Main Authors: M. Selim, Hamouda M. Mousa, Muhammad Umar Aslam Khan, Gamal T. Abdel-Jaber, Nabisab Mujawar Mubarak, Ahmed Barhoum, Abdulaziz Al-Anazi, Abdalla Abdal-hay
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:Journal of Science: Advanced Materials and Devices
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Online Access:http://www.sciencedirect.com/science/article/pii/S2468217924001370
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author M. Selim
Hamouda M. Mousa
Muhammad Umar Aslam Khan
Gamal T. Abdel-Jaber
Nabisab Mujawar Mubarak
Ahmed Barhoum
Abdulaziz Al-Anazi
Abdalla Abdal-hay
author_facet M. Selim
Hamouda M. Mousa
Muhammad Umar Aslam Khan
Gamal T. Abdel-Jaber
Nabisab Mujawar Mubarak
Ahmed Barhoum
Abdulaziz Al-Anazi
Abdalla Abdal-hay
author_sort M. Selim
collection DOAJ
description Bone tissue engineering holds promise for addressing bone injuries by using biomaterial-based 3D scaffolds. The efficacy of these scaffolds is paramount, relying heavily on their ability to interact with cells and facilitate tissue regeneration. This comprehensive review delves into various modification and functionalization strategies to enhance the performance of biomaterial 3D scaffolds in bone tissue engineering. The review encompasses a wide range of techniques, including physical methods such as surface roughening and patterning, and chemical modifications like plasma treatment and functional group grafting. Additionally, surface-coating approaches employing biomolecules and nanoparticles are explored. Synthesizing current research findings offers valuable insights into optimizing biomaterial scaffolds for effective bone tissue regeneration applications. In addition, discussions encompass the influence of scaffold morphology, mechanical properties, and degradation kinetics on cellular responses and tissue integration. By thoroughly examining these strategies, future research will be guided toward developing advanced biomaterial scaffolds tailored specifically for bone tissue engineering applications.
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institution Kabale University
issn 2468-2179
language English
publishDate 2024-12-01
publisher Elsevier
record_format Article
series Journal of Science: Advanced Materials and Devices
spelling doaj-art-575c84e18ea1493a84e75dfc5f79a84a2024-12-13T11:00:33ZengElsevierJournal of Science: Advanced Materials and Devices2468-21792024-12-0194100806Enhancing 3D scaffold performance for bone tissue engineering: A comprehensive review of modification and functionalization strategiesM. Selim0Hamouda M. Mousa1Muhammad Umar Aslam Khan2Gamal T. Abdel-Jaber3Nabisab Mujawar Mubarak4Ahmed Barhoum5Abdulaziz Al-Anazi6Abdalla Abdal-hay7Department of Mechanical Engineering, Faculty of Engineering South Valley University, Qena, 83523, EgyptDepartment of Mechanical Engineering, Faculty of Engineering South Valley University, Qena, 83523, Egypt; Faculty of Technological Industry and Energy, Thebes Technological University, Thebes, Luxor, 85863, EgyptDepartment of Mechanical and Industrial Engineering, Qatar University, Doha, 2713, Qatar; Biomedical Research Center, Qatar University, Doha, 2713, QatarDepartment of Mechanical Engineering, Faculty of Engineering South Valley University, Qena, 83523, EgyptPetroleum and Chemical Engineering, Faculty of Engineering, Universiti Teknologi Brunei, Bandar Seri Begawan, BE1410, Brunei Darussalam; Department of Chemistry, School of Chemical Engineering and Physical Sciences, Lovely Professional University, Jalandhar, Punjab, India; Centre for Research Impact & Outcome, Chitkara University Institute of Engineering and Technology, Chitkara University, Rajpura, 140401, Punjab, IndiaNanoStruc Research Group, Chemistry Department, Faculty of Science, Helwan University, Cairo, 11795, EgyptDepartment of Chemical Engineering, College of Engineering, King Saud University, P.O. Box 800, Riyadh, 11421, Saudi Arabia; Corresponding author.Department of Mechanical Engineering, Faculty of Engineering South Valley University, Qena, 83523, Egypt; School of Dentistry, The University of Queensland, Herston, QLD, 4006, Australia; Centre for Orofacial Regeneration, Reconstruction and Rehabilitation (COR3), Herston, QLD, 4006, Australia; Corresponding author. Department of Mechanical Engineering, Faculty of Engineering South Valley University, Qena, 83523, Egypt.Bone tissue engineering holds promise for addressing bone injuries by using biomaterial-based 3D scaffolds. The efficacy of these scaffolds is paramount, relying heavily on their ability to interact with cells and facilitate tissue regeneration. This comprehensive review delves into various modification and functionalization strategies to enhance the performance of biomaterial 3D scaffolds in bone tissue engineering. The review encompasses a wide range of techniques, including physical methods such as surface roughening and patterning, and chemical modifications like plasma treatment and functional group grafting. Additionally, surface-coating approaches employing biomolecules and nanoparticles are explored. Synthesizing current research findings offers valuable insights into optimizing biomaterial scaffolds for effective bone tissue regeneration applications. In addition, discussions encompass the influence of scaffold morphology, mechanical properties, and degradation kinetics on cellular responses and tissue integration. By thoroughly examining these strategies, future research will be guided toward developing advanced biomaterial scaffolds tailored specifically for bone tissue engineering applications.http://www.sciencedirect.com/science/article/pii/S2468217924001370Bone tissue engineeringBiomaterialsNanoparticle integration3D scaffoldsSurface coatingTissue regeneration
spellingShingle M. Selim
Hamouda M. Mousa
Muhammad Umar Aslam Khan
Gamal T. Abdel-Jaber
Nabisab Mujawar Mubarak
Ahmed Barhoum
Abdulaziz Al-Anazi
Abdalla Abdal-hay
Enhancing 3D scaffold performance for bone tissue engineering: A comprehensive review of modification and functionalization strategies
Journal of Science: Advanced Materials and Devices
Bone tissue engineering
Biomaterials
Nanoparticle integration
3D scaffolds
Surface coating
Tissue regeneration
title Enhancing 3D scaffold performance for bone tissue engineering: A comprehensive review of modification and functionalization strategies
title_full Enhancing 3D scaffold performance for bone tissue engineering: A comprehensive review of modification and functionalization strategies
title_fullStr Enhancing 3D scaffold performance for bone tissue engineering: A comprehensive review of modification and functionalization strategies
title_full_unstemmed Enhancing 3D scaffold performance for bone tissue engineering: A comprehensive review of modification and functionalization strategies
title_short Enhancing 3D scaffold performance for bone tissue engineering: A comprehensive review of modification and functionalization strategies
title_sort enhancing 3d scaffold performance for bone tissue engineering a comprehensive review of modification and functionalization strategies
topic Bone tissue engineering
Biomaterials
Nanoparticle integration
3D scaffolds
Surface coating
Tissue regeneration
url http://www.sciencedirect.com/science/article/pii/S2468217924001370
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