Blautia producta displays potential probiotic properties against dextran sulfate sodium-induced colitis in mice
Blautia has attracted attention because of its potential efficacy in ameliorating host energy metabolism and inflammation. This study aims to investigate the influences of Blautia producta D4 on colitis induced by dextran sulfate sodium (DSS) and to reveal the underlying mechanisms. Results showed t...
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| Format: | Article |
| Language: | English |
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Tsinghua University Press
2024-03-01
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| Series: | Food Science and Human Wellness |
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| Online Access: | https://www.sciopen.com/article/10.26599/FSHW.2022.9250060 |
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| author | Bingyong Mao Weiling Guo Shumao Cui Qiuxiang Zhang Jianxin Zhao Xin Tang Hao Zhang |
| author_facet | Bingyong Mao Weiling Guo Shumao Cui Qiuxiang Zhang Jianxin Zhao Xin Tang Hao Zhang |
| author_sort | Bingyong Mao |
| collection | DOAJ |
| description | Blautia has attracted attention because of its potential efficacy in ameliorating host energy metabolism and inflammation. This study aims to investigate the influences of Blautia producta D4 on colitis induced by dextran sulfate sodium (DSS) and to reveal the underlying mechanisms. Results showed that B. producta D4 intervention significantly relieved body weight loss, and suppressed the elevation of pro-inflammatory cytokines (including interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), and interleukin-1β (IL-1β)) and excessive oxidative stress (myeloperoxidease (MPO) activity, superoxide dismutase (SOD) activity, glutathione peroxidase (GSH-Px) activity, and malondialdehyde (MDA) level) in colitis mice. Moreover, the concentrations of tight junction proteins (occludin, claudin-1, and ZO-1) related to the intestinal barrier were obviously elevated, and colitis-related TLR4/NF-κB pathway activation was remarkably inhibited after B. producta D4 intervention. The intestinal microbial disorder was evidently ameliorated by increasing the relative abundance of Clostridium sensu stricto 1, Bifidobacterium, GCA-900066225, Enterorhabdus, and reducing the relative abundance of Lachnospiraceae NK4A136 group. In conclusion, oral administration of B. producta D4 could ameliorate DSS-induced colitis by suppressing inflammatory responses, maintaining the intestinal barrier, inhibiting TLR4/NF-κB pathway, and regulating intestinal microbiota balance. These results are conducive to accelerate the development of B. producta D4 as a functional probiotic for colitis. |
| format | Article |
| id | doaj-art-5748c7e6a8c748bd9b01edbc65099b29 |
| institution | Kabale University |
| issn | 2213-4530 |
| language | English |
| publishDate | 2024-03-01 |
| publisher | Tsinghua University Press |
| record_format | Article |
| series | Food Science and Human Wellness |
| spelling | doaj-art-5748c7e6a8c748bd9b01edbc65099b292024-12-29T16:00:05ZengTsinghua University PressFood Science and Human Wellness2213-45302024-03-0113270972010.26599/FSHW.2022.9250060Blautia producta displays potential probiotic properties against dextran sulfate sodium-induced colitis in miceBingyong Mao0Weiling Guo1Shumao Cui2Qiuxiang Zhang3Jianxin Zhao4Xin Tang5Hao Zhang6State Key Laboratory of Food Science and Resources, Jiangnan University, Wuxi 214122, ChinaState Key Laboratory of Food Science and Resources, Jiangnan University, Wuxi 214122, ChinaState Key Laboratory of Food Science and Resources, Jiangnan University, Wuxi 214122, ChinaState Key Laboratory of Food Science and Resources, Jiangnan University, Wuxi 214122, ChinaState Key Laboratory of Food Science and Resources, Jiangnan University, Wuxi 214122, ChinaState Key Laboratory of Food Science and Resources, Jiangnan University, Wuxi 214122, ChinaState Key Laboratory of Food Science and Resources, Jiangnan University, Wuxi 214122, ChinaBlautia has attracted attention because of its potential efficacy in ameliorating host energy metabolism and inflammation. This study aims to investigate the influences of Blautia producta D4 on colitis induced by dextran sulfate sodium (DSS) and to reveal the underlying mechanisms. Results showed that B. producta D4 intervention significantly relieved body weight loss, and suppressed the elevation of pro-inflammatory cytokines (including interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), and interleukin-1β (IL-1β)) and excessive oxidative stress (myeloperoxidease (MPO) activity, superoxide dismutase (SOD) activity, glutathione peroxidase (GSH-Px) activity, and malondialdehyde (MDA) level) in colitis mice. Moreover, the concentrations of tight junction proteins (occludin, claudin-1, and ZO-1) related to the intestinal barrier were obviously elevated, and colitis-related TLR4/NF-κB pathway activation was remarkably inhibited after B. producta D4 intervention. The intestinal microbial disorder was evidently ameliorated by increasing the relative abundance of Clostridium sensu stricto 1, Bifidobacterium, GCA-900066225, Enterorhabdus, and reducing the relative abundance of Lachnospiraceae NK4A136 group. In conclusion, oral administration of B. producta D4 could ameliorate DSS-induced colitis by suppressing inflammatory responses, maintaining the intestinal barrier, inhibiting TLR4/NF-κB pathway, and regulating intestinal microbiota balance. These results are conducive to accelerate the development of B. producta D4 as a functional probiotic for colitis.https://www.sciopen.com/article/10.26599/FSHW.2022.9250060blautia producta d4colitisintestinal mechanical barriertlr4/nf-κb pathwayintestinal microbiot |
| spellingShingle | Bingyong Mao Weiling Guo Shumao Cui Qiuxiang Zhang Jianxin Zhao Xin Tang Hao Zhang Blautia producta displays potential probiotic properties against dextran sulfate sodium-induced colitis in mice Food Science and Human Wellness blautia producta d4 colitis intestinal mechanical barrier tlr4/nf-κb pathway intestinal microbiot |
| title | Blautia producta displays potential probiotic properties against dextran sulfate sodium-induced colitis in mice |
| title_full | Blautia producta displays potential probiotic properties against dextran sulfate sodium-induced colitis in mice |
| title_fullStr | Blautia producta displays potential probiotic properties against dextran sulfate sodium-induced colitis in mice |
| title_full_unstemmed | Blautia producta displays potential probiotic properties against dextran sulfate sodium-induced colitis in mice |
| title_short | Blautia producta displays potential probiotic properties against dextran sulfate sodium-induced colitis in mice |
| title_sort | blautia producta displays potential probiotic properties against dextran sulfate sodium induced colitis in mice |
| topic | blautia producta d4 colitis intestinal mechanical barrier tlr4/nf-κb pathway intestinal microbiot |
| url | https://www.sciopen.com/article/10.26599/FSHW.2022.9250060 |
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