Lipid-Based Nanoformulations for Drug Delivery: An Ongoing Perspective
Oils and lipids help make water-insoluble drugs soluble by dispersing them in an aqueous medium with the help of a surfactant and enabling their absorption across the gut barrier. The emergence of microemulsions (thermodynamically stable), nanoemulsions (kinetically stable), and self-emulsifying dru...
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| Format: | Article |
| Language: | English |
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2024-10-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/16/11/1376 |
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| author | Mubashar Rehman Nayab Tahir Muhammad Farhan Sohail Muhammad Usman Qadri Sofia O. D. Duarte Pedro Brandão Teresa Esteves Ibrahim Javed Pedro Fonte |
| author_facet | Mubashar Rehman Nayab Tahir Muhammad Farhan Sohail Muhammad Usman Qadri Sofia O. D. Duarte Pedro Brandão Teresa Esteves Ibrahim Javed Pedro Fonte |
| author_sort | Mubashar Rehman |
| collection | DOAJ |
| description | Oils and lipids help make water-insoluble drugs soluble by dispersing them in an aqueous medium with the help of a surfactant and enabling their absorption across the gut barrier. The emergence of microemulsions (thermodynamically stable), nanoemulsions (kinetically stable), and self-emulsifying drug delivery systems added unique characteristics that make them suitable for prolonged storage and controlled release. In the 1990s, solid-phase lipids were introduced to reduce drug leakage from nanoparticles and prolong drug release. Manipulating the structure of emulsions and solid lipid nanoparticles has enabled multifunctional nanoparticles and the loading of therapeutic macromolecules such as proteins, nucleic acid, vaccines, etc. Phospholipids and surfactants with a well-defined polar head and carbon chain have been used to prepare bilayer vesicles known as liposomes and niosomes, respectively. The increasing knowledge of targeting ligands and external factors to gain control over pharmacokinetics and the ever-increasing number of synthetic lipids are expected to make lipid nanoparticles and vesicular systems a preferred choice for the encapsulation and targeted delivery of therapeutic agents. This review discusses different lipids and oil-based nanoparticulate systems for the delivery of water-insoluble drugs. The salient features of each system are highlighted, and special emphasis is given to studies that compare them. |
| format | Article |
| id | doaj-art-570f35d257d84a96895c4b2599cae3fc |
| institution | Kabale University |
| issn | 1999-4923 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj-art-570f35d257d84a96895c4b2599cae3fc2024-11-26T18:17:44ZengMDPI AGPharmaceutics1999-49232024-10-011611137610.3390/pharmaceutics16111376Lipid-Based Nanoformulations for Drug Delivery: An Ongoing PerspectiveMubashar Rehman0Nayab Tahir1Muhammad Farhan Sohail2Muhammad Usman Qadri3Sofia O. D. Duarte4Pedro Brandão5Teresa Esteves6Ibrahim Javed7Pedro Fonte8Department of Pharmacy, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad 45320, PakistanCollege of Pharmacy, University of Sargodha, Sargodha 40100, PakistanDepartment of Pharmacy, University of South Asia, Lahore 54000, PakistanAustralian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, QLD 4072, AustraliaDepartment of Bioengineering, iBB-Institute for Bioengineering and Biosciences, Instituto Superior Técnico, University of Lisboa, Av. Rovisco Pais, 1049-001 Lisbon, PortugalDepartment of Bioengineering, iBB-Institute for Bioengineering and Biosciences, Instituto Superior Técnico, University of Lisboa, Av. Rovisco Pais, 1049-001 Lisbon, PortugalDepartment of Bioengineering, iBB-Institute for Bioengineering and Biosciences, Instituto Superior Técnico, University of Lisboa, Av. Rovisco Pais, 1049-001 Lisbon, PortugalAustralian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, QLD 4072, AustraliaDepartment of Bioengineering, iBB-Institute for Bioengineering and Biosciences, Instituto Superior Técnico, University of Lisboa, Av. Rovisco Pais, 1049-001 Lisbon, PortugalOils and lipids help make water-insoluble drugs soluble by dispersing them in an aqueous medium with the help of a surfactant and enabling their absorption across the gut barrier. The emergence of microemulsions (thermodynamically stable), nanoemulsions (kinetically stable), and self-emulsifying drug delivery systems added unique characteristics that make them suitable for prolonged storage and controlled release. In the 1990s, solid-phase lipids were introduced to reduce drug leakage from nanoparticles and prolong drug release. Manipulating the structure of emulsions and solid lipid nanoparticles has enabled multifunctional nanoparticles and the loading of therapeutic macromolecules such as proteins, nucleic acid, vaccines, etc. Phospholipids and surfactants with a well-defined polar head and carbon chain have been used to prepare bilayer vesicles known as liposomes and niosomes, respectively. The increasing knowledge of targeting ligands and external factors to gain control over pharmacokinetics and the ever-increasing number of synthetic lipids are expected to make lipid nanoparticles and vesicular systems a preferred choice for the encapsulation and targeted delivery of therapeutic agents. This review discusses different lipids and oil-based nanoparticulate systems for the delivery of water-insoluble drugs. The salient features of each system are highlighted, and special emphasis is given to studies that compare them.https://www.mdpi.com/1999-4923/16/11/1376liposomesSLNtargetingcontrolled releasesolubility enhancementvaccine |
| spellingShingle | Mubashar Rehman Nayab Tahir Muhammad Farhan Sohail Muhammad Usman Qadri Sofia O. D. Duarte Pedro Brandão Teresa Esteves Ibrahim Javed Pedro Fonte Lipid-Based Nanoformulations for Drug Delivery: An Ongoing Perspective Pharmaceutics liposomes SLN targeting controlled release solubility enhancement vaccine |
| title | Lipid-Based Nanoformulations for Drug Delivery: An Ongoing Perspective |
| title_full | Lipid-Based Nanoformulations for Drug Delivery: An Ongoing Perspective |
| title_fullStr | Lipid-Based Nanoformulations for Drug Delivery: An Ongoing Perspective |
| title_full_unstemmed | Lipid-Based Nanoformulations for Drug Delivery: An Ongoing Perspective |
| title_short | Lipid-Based Nanoformulations for Drug Delivery: An Ongoing Perspective |
| title_sort | lipid based nanoformulations for drug delivery an ongoing perspective |
| topic | liposomes SLN targeting controlled release solubility enhancement vaccine |
| url | https://www.mdpi.com/1999-4923/16/11/1376 |
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