Metabolic modulation to improve MSC expansion and therapeutic potential for articular cartilage repair

Metabolic modulation to improve MSC expansion and therapeutic potential for articular cartilage repair

Abstract Background Articular cartilage degeneration can result from injury, age, or arthritis, causing significant joint pain and disability without surgical intervention. Currently, the only FDA cell-based therapy for articular cartilage injury is Autologous Chondrocyte Implantation (ACI); however...

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Main Authors: Ching Ann Tee, Daniel Ninio Roxby, Rashidah Othman, Vinitha Denslin, Kiesar Sideeq Bhat, Zheng Yang, Jongyoon Han, Lisa Tucker-Kellogg, Laurie A. Boyer
Format: Article
Language:English
Published: BMC 2024-09-01
Series:Stem Cell Research & Therapy
Subjects:
Mesenchymal stromal cells
Metabolic modulation
Articular cartilage
Cell expansion
In-process monitoring tools
Critical quality attributes
Online Access:https://doi.org/10.1186/s13287-024-03923-w
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https://doi.org/10.1186/s13287-024-03923-w

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