Constipation among workers with depression/anxiety: a retrospective study using a claims database and survey data in Japan
Objectives To investigate the prevalence, associated factors, treatment status and burden of constipation in workers with depression or anxiety.Study design This was a retrospective observational study using a pre-existing database.Setting Claims data from October to November 2022 and data from the...
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BMJ Publishing Group
2024-11-01
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| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/14/11/e083668.full |
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| author | Shin Fukudo Kazutaka Nozawa Yusuke Karasawa Keisuke Nomoto |
| author_facet | Shin Fukudo Kazutaka Nozawa Yusuke Karasawa Keisuke Nomoto |
| author_sort | Shin Fukudo |
| collection | DOAJ |
| description | Objectives To investigate the prevalence, associated factors, treatment status and burden of constipation in workers with depression or anxiety.Study design This was a retrospective observational study using a pre-existing database.Setting Claims data from October to November 2022 and data from the survey conducted in November 2022 were extracted from the database.Participants This study included self-reported workers who completed the survey, after excluding those with major mental disorders diagnosed as distinct from depression or anxiety and constipation due to organic diseases identified by International Classification of Diseases (ICD-10) codes.Outcome measures The subjects were divided into three groups: treated depression/anxiety, untreated depression/anxiety and no depression/anxiety. The prevalence of constipation, factors associated with constipation and medications prescribed for constipation were analysed. Work productivity and quality of life (QOL) were compared between three subgroups based on constipation status: treated constipation, untreated constipation and no constipation subgroup.Results Of the 18 585 respondents in the analysis population, 950 respondents (5.1%) were classified into the treated depression/anxiety group, 6035 respondents (32.5%) into the untreated depression/anxiety group and the remaining respondents into the no depression/anxiety group (11 600 (62.4%)). The prevalence of constipation was 22.5% in the treated group, 22.3% in the untreated group and 10.4% in the no depression/anxiety group, respectively. Depression and anxiety severity were independently associated with an increased risk of constipation. In all groups, the most commonly prescribed drug class was osmotic laxatives. Work productivity and QOL tended to indicate a greater burden in the untreated constipation subgroup than in the treated or no constipation subgroups.Conclusions The prevalence of constipation was twice as high if workers had depression/anxiety. Considering that the comorbidity of constipation with mental disorders may increase multiple burdens, appropriate medical interventions are required to treat both mental (depression/anxiety) and physical (constipation) conditions. This should be widely recognised by physicians and employers. |
| format | Article |
| id | doaj-art-56d8567181584c30889bf4d97d59a32f |
| institution | Kabale University |
| issn | 2044-6055 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj-art-56d8567181584c30889bf4d97d59a32f2024-11-26T04:40:14ZengBMJ Publishing GroupBMJ Open2044-60552024-11-01141110.1136/bmjopen-2023-083668Constipation among workers with depression/anxiety: a retrospective study using a claims database and survey data in JapanShin Fukudo0Kazutaka Nozawa1Yusuke Karasawa2Keisuke Nomoto32 Department of Behavioral Medicine, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan1 Medical Affairs, Viatris Pharmaceuticals Japan Inc, Minato-ku, Japan1 Medical Affairs, Viatris Pharmaceuticals Japan Inc, Minato-ku, Japan1 Medical Affairs, Viatris Pharmaceuticals Japan Inc, Minato-ku, JapanObjectives To investigate the prevalence, associated factors, treatment status and burden of constipation in workers with depression or anxiety.Study design This was a retrospective observational study using a pre-existing database.Setting Claims data from October to November 2022 and data from the survey conducted in November 2022 were extracted from the database.Participants This study included self-reported workers who completed the survey, after excluding those with major mental disorders diagnosed as distinct from depression or anxiety and constipation due to organic diseases identified by International Classification of Diseases (ICD-10) codes.Outcome measures The subjects were divided into three groups: treated depression/anxiety, untreated depression/anxiety and no depression/anxiety. The prevalence of constipation, factors associated with constipation and medications prescribed for constipation were analysed. Work productivity and quality of life (QOL) were compared between three subgroups based on constipation status: treated constipation, untreated constipation and no constipation subgroup.Results Of the 18 585 respondents in the analysis population, 950 respondents (5.1%) were classified into the treated depression/anxiety group, 6035 respondents (32.5%) into the untreated depression/anxiety group and the remaining respondents into the no depression/anxiety group (11 600 (62.4%)). The prevalence of constipation was 22.5% in the treated group, 22.3% in the untreated group and 10.4% in the no depression/anxiety group, respectively. Depression and anxiety severity were independently associated with an increased risk of constipation. In all groups, the most commonly prescribed drug class was osmotic laxatives. Work productivity and QOL tended to indicate a greater burden in the untreated constipation subgroup than in the treated or no constipation subgroups.Conclusions The prevalence of constipation was twice as high if workers had depression/anxiety. Considering that the comorbidity of constipation with mental disorders may increase multiple burdens, appropriate medical interventions are required to treat both mental (depression/anxiety) and physical (constipation) conditions. This should be widely recognised by physicians and employers.https://bmjopen.bmj.com/content/14/11/e083668.full |
| spellingShingle | Shin Fukudo Kazutaka Nozawa Yusuke Karasawa Keisuke Nomoto Constipation among workers with depression/anxiety: a retrospective study using a claims database and survey data in Japan BMJ Open |
| title | Constipation among workers with depression/anxiety: a retrospective study using a claims database and survey data in Japan |
| title_full | Constipation among workers with depression/anxiety: a retrospective study using a claims database and survey data in Japan |
| title_fullStr | Constipation among workers with depression/anxiety: a retrospective study using a claims database and survey data in Japan |
| title_full_unstemmed | Constipation among workers with depression/anxiety: a retrospective study using a claims database and survey data in Japan |
| title_short | Constipation among workers with depression/anxiety: a retrospective study using a claims database and survey data in Japan |
| title_sort | constipation among workers with depression anxiety a retrospective study using a claims database and survey data in japan |
| url | https://bmjopen.bmj.com/content/14/11/e083668.full |
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