Visceral Perforation Complicating BRAF/MEK Targeted Therapy of Papillary Thyroid Carcinoma with Anaplastic Areas

Visceral Perforation Complicating BRAF/MEK Targeted Therapy of Papillary Thyroid Carcinoma with Anaplastic Areas

Anaplastic thyroid cancer (ATC) is considered to be one of the most virulent, treatment-refractory malignancies. Recent molecular insights into the biology of thyroid cancer have transformed ATC management, and BRAF/MEK targeted therapy is now incorporated into guideline-based multidisciplinary care...

Full description

Saved in:
Bibliographic Details
Main Authors: Simon L. Barry, Emer Lynch, Philip Bredin, Sebastian McWilliams, Julie McCarthy, Orla O’Mahony, Linda Feeley, Killian Nugent, Patrick Sheahan, Deirdre O’Hanlon, David O’Reilly, Seamus O’Reilly
Format: Article
Language:English
Published: MDPI AG 2024-12-01
Series:Onco
Subjects:
anaplastic thyroid carcinoma
targeted therapy
perforation
complications
Online Access:https://www.mdpi.com/2673-7523/4/4/30
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Anaplastic thyroid cancer (ATC) is considered to be one of the most virulent, treatment-refractory malignancies. Recent molecular insights into the biology of thyroid cancer have transformed ATC management, and BRAF/MEK targeted therapy is now incorporated into guideline-based multidisciplinary care. We report visceral perforation in the setting of an extreme response to such therapy in a patient with ATC. Molecularly targeted therapy afforded a dramatic but life-threatening response to treatment. This report highlights the complexities of care for the patient and treating clinicians.
ISSN:2673-7523

Similar Items