Primary ovarian insufficiency consequence of autoimmune diseases: a bidirectional two-sample Mendelian randomization study

Primary ovarian insufficiency consequence of autoimmune diseases: a bidirectional two-sample Mendelian randomization study

BackgroundObservational studies suggest the risk of primary ovarian insufficiency (POI) is increased in autoimmune disorders (AIDs), but it is unclear whether there is a causal relationship. Therefore, we aimed to investigate the bidirectional causality between 20 AIDs and POI using Mendelian random...

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Bibliographic Details
Main Authors: Yongming Du, Yichao Hu, Yuehua Sheng, Tianhong Zhu, Shenping Liu, Huiqing Ding, Yutao Guan
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-12-01
Series:Frontiers in Endocrinology
Subjects:
autoimmune disease
primary ovarian insufficiency
Mendelian randomization
single-nucleotide polymorphisms
causal association
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2024.1417896/full
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