Assessment of the Relationship Between Genetic Determinants of Obesity, Unhealthy Eating Habits and Chronic Obstructive Pulmonary Disease: A Mendelian Randomisation Study
Background: Clinical studies have shown that the onset and exacerbation of chronic obstructive pulmonary disease (COPD) are related to obesity and dietary behaviours, but the genetic relationship between them is not clear.Aims: To investigate the relationship between the genetic determinants of obes...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2024-12-01
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| Series: | COPD |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/15412555.2024.2309236 |
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| author | Tongyao Sun Jun Wang Min Zheng Chengsen Cai Jianjian Yu Lina Fu Lei Duan |
| author_facet | Tongyao Sun Jun Wang Min Zheng Chengsen Cai Jianjian Yu Lina Fu Lei Duan |
| author_sort | Tongyao Sun |
| collection | DOAJ |
| description | Background: Clinical studies have shown that the onset and exacerbation of chronic obstructive pulmonary disease (COPD) are related to obesity and dietary behaviours, but the genetic relationship between them is not clear.Aims: To investigate the relationship between the genetic determinants of obesity, dietary habits (alcohol consumption, intake of sweets, salt intake) and COPD.Methods: Exposure and outcome datasets were obtained from the IEU Open GWAS project. The exposure dataset includes dietary habits (Salt added to food, Sweets intake, Alcohol consumption), obesity level (represented by body mass index (BMI) and body fat percentage (BFP) data sets.). The outcome dataset includes COPD and acute COPD admissions. The collected data were imported into the RStudio software and conducted Mendelian randomisation analysis. Additionally, heterogeneity and horizontal pleiotropy tests were conducted on the data to ensure the veracity of the results.Results: The results showed that BMI was positively correlated with the risk of acute COPD admission (OR = 1.74, 95% CI 1.39–2.18) and COPD (OR = 1.81, 95%CI 1.41–2.33). In addition, BFP was also a risk factor for COPD (OR = 1.98, 95% CI 1.42–2.77) and acute exacerbation of COPD admission (OR = 1.99, 95%CI 1.43–2.77). The increase of salt, sugar and alcohol consumption will not increase the risk of COPD and the risk of hospitalisation due to COPD.Conclusion: Therefore, we should strengthen the guidance of diet and living habits of obese patients. For patients with heavier weight and higher body fat rate, they should be instructed to lose weight and fat to prevent the occurrence of COPD. For obese patients with COPD, more attention should be paid to prevent the occurrence of acute exacerbation of COPD in advance. |
| format | Article |
| id | doaj-art-560d902d88ba4d6da5d25bf010eee25b |
| institution | Kabale University |
| issn | 1541-2555 1541-2563 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | COPD |
| spelling | doaj-art-560d902d88ba4d6da5d25bf010eee25b2024-12-26T08:50:44ZengTaylor & Francis GroupCOPD1541-25551541-25632024-12-0121110.1080/15412555.2024.2309236Assessment of the Relationship Between Genetic Determinants of Obesity, Unhealthy Eating Habits and Chronic Obstructive Pulmonary Disease: A Mendelian Randomisation StudyTongyao Sun0Jun Wang1Min Zheng2Chengsen Cai3Jianjian Yu4Lina Fu5Lei Duan6Shandong University of Traditional Chinese Medicine First Clinical Medical College, Shandong, China;Respiratory and Critical Care Medicine Department, Shandong University of Traditional Chinese Medicine Second Affiliated Hospital, Shandong, China;Shandong University of Traditional Chinese Medicine First Clinical Medical College, Shandong, China;Respiratory and Critical Care Medicine Department, Shandong University of Traditional Chinese Medicine Second Affiliated Hospital, Shandong, China;Respiratory and Critical Care Medicine Department, Shandong University of Traditional Chinese Medicine Second Affiliated Hospital, Shandong, China;Respiratory and Critical Care Medicine Department, Shandong University of Traditional Chinese Medicine Second Affiliated Hospital, Shandong, China;Medical Affairs Department, Shandong University of Traditional Chinese Medicine Second Affiliated Hospital, Shandong, ChinaBackground: Clinical studies have shown that the onset and exacerbation of chronic obstructive pulmonary disease (COPD) are related to obesity and dietary behaviours, but the genetic relationship between them is not clear.Aims: To investigate the relationship between the genetic determinants of obesity, dietary habits (alcohol consumption, intake of sweets, salt intake) and COPD.Methods: Exposure and outcome datasets were obtained from the IEU Open GWAS project. The exposure dataset includes dietary habits (Salt added to food, Sweets intake, Alcohol consumption), obesity level (represented by body mass index (BMI) and body fat percentage (BFP) data sets.). The outcome dataset includes COPD and acute COPD admissions. The collected data were imported into the RStudio software and conducted Mendelian randomisation analysis. Additionally, heterogeneity and horizontal pleiotropy tests were conducted on the data to ensure the veracity of the results.Results: The results showed that BMI was positively correlated with the risk of acute COPD admission (OR = 1.74, 95% CI 1.39–2.18) and COPD (OR = 1.81, 95%CI 1.41–2.33). In addition, BFP was also a risk factor for COPD (OR = 1.98, 95% CI 1.42–2.77) and acute exacerbation of COPD admission (OR = 1.99, 95%CI 1.43–2.77). The increase of salt, sugar and alcohol consumption will not increase the risk of COPD and the risk of hospitalisation due to COPD.Conclusion: Therefore, we should strengthen the guidance of diet and living habits of obese patients. For patients with heavier weight and higher body fat rate, they should be instructed to lose weight and fat to prevent the occurrence of COPD. For obese patients with COPD, more attention should be paid to prevent the occurrence of acute exacerbation of COPD in advance.https://www.tandfonline.com/doi/10.1080/15412555.2024.2309236chronic obstructive pulmonary diseaseobesitymendelian randomisation analysisdietary habits |
| spellingShingle | Tongyao Sun Jun Wang Min Zheng Chengsen Cai Jianjian Yu Lina Fu Lei Duan Assessment of the Relationship Between Genetic Determinants of Obesity, Unhealthy Eating Habits and Chronic Obstructive Pulmonary Disease: A Mendelian Randomisation Study COPD chronic obstructive pulmonary disease obesity mendelian randomisation analysis dietary habits |
| title | Assessment of the Relationship Between Genetic Determinants of Obesity, Unhealthy Eating Habits and Chronic Obstructive Pulmonary Disease: A Mendelian Randomisation Study |
| title_full | Assessment of the Relationship Between Genetic Determinants of Obesity, Unhealthy Eating Habits and Chronic Obstructive Pulmonary Disease: A Mendelian Randomisation Study |
| title_fullStr | Assessment of the Relationship Between Genetic Determinants of Obesity, Unhealthy Eating Habits and Chronic Obstructive Pulmonary Disease: A Mendelian Randomisation Study |
| title_full_unstemmed | Assessment of the Relationship Between Genetic Determinants of Obesity, Unhealthy Eating Habits and Chronic Obstructive Pulmonary Disease: A Mendelian Randomisation Study |
| title_short | Assessment of the Relationship Between Genetic Determinants of Obesity, Unhealthy Eating Habits and Chronic Obstructive Pulmonary Disease: A Mendelian Randomisation Study |
| title_sort | assessment of the relationship between genetic determinants of obesity unhealthy eating habits and chronic obstructive pulmonary disease a mendelian randomisation study |
| topic | chronic obstructive pulmonary disease obesity mendelian randomisation analysis dietary habits |
| url | https://www.tandfonline.com/doi/10.1080/15412555.2024.2309236 |
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