The SLaM Brain Health Clinic: remote biomarker enhanced memory clinic for people with mild cognitive impairment within a National Health Service mental health trust
Background The novel South London and Maudsley Brain Health Clinic (SLaM BHC) leverages advances in remote consultations and biomarkers to provide a timely, cost-efficient and accurate diagnosis in mild cognitive impairment (MCI). Aims To describe the organisation, patient cohort and acceptability...
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| Format: | Article |
| Language: | English |
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Cambridge University Press
2025-01-01
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| Series: | BJPsych Open |
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| Online Access: | https://www.cambridge.org/core/product/identifier/S2056472424008299/type/journal_article |
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| author | Ashwin V. Venkataraman Pooja Kandangwa Roos Lemmen Rutvi Savla Mazda Beigi Devon Hammond Daniel Harwood Justin Sauer Latha Velayudhan Clive Ballard Anna-Katharine Brem Chris Kalafatis Dag Aarsland |
| author_facet | Ashwin V. Venkataraman Pooja Kandangwa Roos Lemmen Rutvi Savla Mazda Beigi Devon Hammond Daniel Harwood Justin Sauer Latha Velayudhan Clive Ballard Anna-Katharine Brem Chris Kalafatis Dag Aarsland |
| author_sort | Ashwin V. Venkataraman |
| collection | DOAJ |
| description | Background
The novel South London and Maudsley Brain Health Clinic (SLaM BHC) leverages advances in remote consultations and biomarkers to provide a timely, cost-efficient and accurate diagnosis in mild cognitive impairment (MCI).
Aims
To describe the organisation, patient cohort and acceptability of the remote diagnostic and interventional procedures.
Method
We describe the recruitment, consultation set-up, the clinical and biomarker programme, and the two online group interventions for cognitive wellbeing and lifestyle change. We evaluate the acceptability of the remote consultations, lumbar puncture, saliva genotyping, and remote cognitive and functional assessments.
Results
We present the results of the first 68 (mean age 73, 55% female, 43% minoritised ethnicity) of 146 people who enrolled for full remote clinical, cognitive, genetic, cerebrospinal fluid and neuroimaging phenotyping. A total of 86% were very satisfied/satisfied with the remote service. In all, 67% consented to lumbar puncture, and 95% of those were very satisfied, all having no significant complications. A total of 93% found taking saliva genotyping very easy/easy, and 93% found the cognitive assessments instructions clear. In all, 98% were satisfied with the Cognitive Wellbeing Group, and 90% of goals were achieved in the Lifestyle Intervention Group.
Conclusions
The SLaM BHC provides a highly acceptable and safe clinical model for remote assessments and lumbar punctures in a representative, ethnically diverse population. This allows early and accurate diagnosis of Alzheimer's disease, differentiation from other MCI causes and targets modifiable risk factors. This is crucial for future disease modification, ensuring equitable access to research, and provides precise, timely and cost-efficient diagnoses in UK mental health services.
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| format | Article |
| id | doaj-art-560bbff5b37c407ca3387431bbd10de0 |
| institution | Kabale University |
| issn | 2056-4724 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Cambridge University Press |
| record_format | Article |
| series | BJPsych Open |
| spelling | doaj-art-560bbff5b37c407ca3387431bbd10de02024-12-19T05:44:34ZengCambridge University PressBJPsych Open2056-47242025-01-011110.1192/bjo.2024.829The SLaM Brain Health Clinic: remote biomarker enhanced memory clinic for people with mild cognitive impairment within a National Health Service mental health trustAshwin V. Venkataraman0https://orcid.org/0000-0001-7977-1948Pooja Kandangwa1Roos Lemmen2Rutvi Savla3Mazda Beigi4Devon Hammond5Daniel Harwood6Justin Sauer7Latha Velayudhan8Clive Ballard9Anna-Katharine Brem10https://orcid.org/0000-0003-0295-6834Chris Kalafatis11Dag Aarsland12https://orcid.org/0000-0001-6314-216XCentre for Healthy Brain Ageing, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK Centre for Neuroimaging Sciences, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK South London and Maudsley NHS Foundation Trust, London, UKCentre for Healthy Brain Ageing, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UKCentre for Healthy Brain Ageing, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UKCentre for Healthy Brain Ageing, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UKSouth London and Maudsley NHS Foundation Trust, London, UKSouth London and Maudsley NHS Foundation Trust, London, UKSouth London and Maudsley NHS Foundation Trust, London, UKSouth London and Maudsley NHS Foundation Trust, London, UKCentre for Healthy Brain Ageing, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK South London and Maudsley NHS Foundation Trust, London, UKCollege of Medicine and Health, University of Exeter, UKCentre for Healthy Brain Ageing, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK University Hospital of Old Age Psychiatry, University of Bern, SwitzerlandCentre for Healthy Brain Ageing, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK South London and Maudsley NHS Foundation Trust, London, UKCentre for Healthy Brain Ageing, Institute of Psychiatry, Psychology & Neuroscience, King's College London, UK South London and Maudsley NHS Foundation Trust, London, UK Centre for Age-Related Research, Stavanger University Hospital, NorwayBackground The novel South London and Maudsley Brain Health Clinic (SLaM BHC) leverages advances in remote consultations and biomarkers to provide a timely, cost-efficient and accurate diagnosis in mild cognitive impairment (MCI). Aims To describe the organisation, patient cohort and acceptability of the remote diagnostic and interventional procedures. Method We describe the recruitment, consultation set-up, the clinical and biomarker programme, and the two online group interventions for cognitive wellbeing and lifestyle change. We evaluate the acceptability of the remote consultations, lumbar puncture, saliva genotyping, and remote cognitive and functional assessments. Results We present the results of the first 68 (mean age 73, 55% female, 43% minoritised ethnicity) of 146 people who enrolled for full remote clinical, cognitive, genetic, cerebrospinal fluid and neuroimaging phenotyping. A total of 86% were very satisfied/satisfied with the remote service. In all, 67% consented to lumbar puncture, and 95% of those were very satisfied, all having no significant complications. A total of 93% found taking saliva genotyping very easy/easy, and 93% found the cognitive assessments instructions clear. In all, 98% were satisfied with the Cognitive Wellbeing Group, and 90% of goals were achieved in the Lifestyle Intervention Group. Conclusions The SLaM BHC provides a highly acceptable and safe clinical model for remote assessments and lumbar punctures in a representative, ethnically diverse population. This allows early and accurate diagnosis of Alzheimer's disease, differentiation from other MCI causes and targets modifiable risk factors. This is crucial for future disease modification, ensuring equitable access to research, and provides precise, timely and cost-efficient diagnoses in UK mental health services. https://www.cambridge.org/core/product/identifier/S2056472424008299/type/journal_articleRemote brain health clinicbiomarkersold age psychiatrymild cognitive impairmentdementia |
| spellingShingle | Ashwin V. Venkataraman Pooja Kandangwa Roos Lemmen Rutvi Savla Mazda Beigi Devon Hammond Daniel Harwood Justin Sauer Latha Velayudhan Clive Ballard Anna-Katharine Brem Chris Kalafatis Dag Aarsland The SLaM Brain Health Clinic: remote biomarker enhanced memory clinic for people with mild cognitive impairment within a National Health Service mental health trust BJPsych Open Remote brain health clinic biomarkers old age psychiatry mild cognitive impairment dementia |
| title | The SLaM Brain Health Clinic: remote biomarker enhanced memory clinic for people with mild cognitive impairment within a National Health Service mental health trust |
| title_full | The SLaM Brain Health Clinic: remote biomarker enhanced memory clinic for people with mild cognitive impairment within a National Health Service mental health trust |
| title_fullStr | The SLaM Brain Health Clinic: remote biomarker enhanced memory clinic for people with mild cognitive impairment within a National Health Service mental health trust |
| title_full_unstemmed | The SLaM Brain Health Clinic: remote biomarker enhanced memory clinic for people with mild cognitive impairment within a National Health Service mental health trust |
| title_short | The SLaM Brain Health Clinic: remote biomarker enhanced memory clinic for people with mild cognitive impairment within a National Health Service mental health trust |
| title_sort | slam brain health clinic remote biomarker enhanced memory clinic for people with mild cognitive impairment within a national health service mental health trust |
| topic | Remote brain health clinic biomarkers old age psychiatry mild cognitive impairment dementia |
| url | https://www.cambridge.org/core/product/identifier/S2056472424008299/type/journal_article |
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