Profiling signaling mediators for cell-cell interactions and communications with microfluidics-based single-cell analysis tools
Summary: Cell-cell interactions and communication represent the fundamental cornerstone of cells’ collaborative efforts in executing diverse biological processes. A profound understanding of how cells interface through various mediators is pivotal across a spectrum of biological systems. Recent stri...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-01-01
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| Series: | iScience |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589004224028906 |
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| _version_ | 1841553813076443136 |
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| author | Shuai Yuan Peng Zhang Feng Zhang Shiqiang Yan Ruihua Dong Chengjun Wu Jiu Deng |
| author_facet | Shuai Yuan Peng Zhang Feng Zhang Shiqiang Yan Ruihua Dong Chengjun Wu Jiu Deng |
| author_sort | Shuai Yuan |
| collection | DOAJ |
| description | Summary: Cell-cell interactions and communication represent the fundamental cornerstone of cells’ collaborative efforts in executing diverse biological processes. A profound understanding of how cells interface through various mediators is pivotal across a spectrum of biological systems. Recent strides in microfluidic technologies have significantly bolstered the precision and prowess in capturing and manipulating cells with exceptional spatial and temporal resolution. These advanced methodologies converge with multi-signal mediator detection systems, furnishing potent, high-throughput platforms for dissecting cell-cell interactions at the single-cell level. This approach empowers researchers to delve into intricate cellular dynamics with unprecedented accuracy and efficiency. Here, we present a critical evaluation of the latest advancements in microfluidics-driven techniques for detecting signal mediators involved in cell-cell interactions and communication at the single-cell level. We underscore notable biological applications that have benefited from these technologies and identify pressing challenges that must be addressed in future endeavors leveraging microfluidic tools for single-cell interaction studies. |
| format | Article |
| id | doaj-art-55f1569b9f9d4a2ea654764057510bf9 |
| institution | Kabale University |
| issn | 2589-0042 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | iScience |
| spelling | doaj-art-55f1569b9f9d4a2ea654764057510bf92025-01-09T06:14:25ZengElsevieriScience2589-00422025-01-01281111663Profiling signaling mediators for cell-cell interactions and communications with microfluidics-based single-cell analysis toolsShuai Yuan0Peng Zhang1Feng Zhang2Shiqiang Yan3Ruihua Dong4Chengjun Wu5Jiu Deng6School of Health and Life Sciences, University of Health and Rehabilitation Sciences, Qingdao 266113, ChinaBiological and Environmental Science and Engineering Division, King Abdullah University of Science and Technology, Thuwal 23955-6900, Saudi ArabiaDepartment of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210000, ChinaCenter of Cancer Immunology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, ChinaSchool of Health and Life Sciences, University of Health and Rehabilitation Sciences, Qingdao 266113, ChinaSchool of Health and Life Sciences, University of Health and Rehabilitation Sciences, Qingdao 266113, China; Corresponding authorSchool of Health and Life Sciences, University of Health and Rehabilitation Sciences, Qingdao 266113, China; Corresponding authorSummary: Cell-cell interactions and communication represent the fundamental cornerstone of cells’ collaborative efforts in executing diverse biological processes. A profound understanding of how cells interface through various mediators is pivotal across a spectrum of biological systems. Recent strides in microfluidic technologies have significantly bolstered the precision and prowess in capturing and manipulating cells with exceptional spatial and temporal resolution. These advanced methodologies converge with multi-signal mediator detection systems, furnishing potent, high-throughput platforms for dissecting cell-cell interactions at the single-cell level. This approach empowers researchers to delve into intricate cellular dynamics with unprecedented accuracy and efficiency. Here, we present a critical evaluation of the latest advancements in microfluidics-driven techniques for detecting signal mediators involved in cell-cell interactions and communication at the single-cell level. We underscore notable biological applications that have benefited from these technologies and identify pressing challenges that must be addressed in future endeavors leveraging microfluidic tools for single-cell interaction studies.http://www.sciencedirect.com/science/article/pii/S2589004224028906FluidicsBiological sciencesBiotechnology |
| spellingShingle | Shuai Yuan Peng Zhang Feng Zhang Shiqiang Yan Ruihua Dong Chengjun Wu Jiu Deng Profiling signaling mediators for cell-cell interactions and communications with microfluidics-based single-cell analysis tools iScience Fluidics Biological sciences Biotechnology |
| title | Profiling signaling mediators for cell-cell interactions and communications with microfluidics-based single-cell analysis tools |
| title_full | Profiling signaling mediators for cell-cell interactions and communications with microfluidics-based single-cell analysis tools |
| title_fullStr | Profiling signaling mediators for cell-cell interactions and communications with microfluidics-based single-cell analysis tools |
| title_full_unstemmed | Profiling signaling mediators for cell-cell interactions and communications with microfluidics-based single-cell analysis tools |
| title_short | Profiling signaling mediators for cell-cell interactions and communications with microfluidics-based single-cell analysis tools |
| title_sort | profiling signaling mediators for cell cell interactions and communications with microfluidics based single cell analysis tools |
| topic | Fluidics Biological sciences Biotechnology |
| url | http://www.sciencedirect.com/science/article/pii/S2589004224028906 |
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