Niclosamide piperazine solubility in supercritical CO2 green solvent: A comprehensive experimental and modeling investigation
In order to micro and Nano sizing a drug via supercritical fluid technology, it is necessary to obtain its solubility in various ranges of pressures and temperatures. For this purpose, solubility of Niclosamide piperazine, in supercritical carbon dioxide (SC-CO2) was measured by a new static method,...
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Elsevier
2025-01-01
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| Series: | Journal of CO2 Utilization |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2212982024003305 |
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| author | Gholamhossein Sodeifian Hamidreza Bagheri Farnoush Masihpour Negar Rajaei Maryam Arbab Nooshabadi |
| author_facet | Gholamhossein Sodeifian Hamidreza Bagheri Farnoush Masihpour Negar Rajaei Maryam Arbab Nooshabadi |
| author_sort | Gholamhossein Sodeifian |
| collection | DOAJ |
| description | In order to micro and Nano sizing a drug via supercritical fluid technology, it is necessary to obtain its solubility in various ranges of pressures and temperatures. For this purpose, solubility of Niclosamide piperazine, in supercritical carbon dioxide (SC-CO2) was measured by a new static method, for the first time. The measurements were performed at various circumstances, i.e. temperatures = 308, 318, 328 and 338 K and pressures = 12–27 MPa. The obtained results indicate that pressure significantly influences the solubility of Niclosamide piperazine, with a measured solubility ranging from 0.77 × 10−7 to 13.60 × 10−7 in mole fraction. To study theoretically the solubility of Niclosamide piperazine, the obtained results are modeled using nine semi-empirical equations i.e. Garlapati-Madras, Chrastil, Kumar-Johnston, Sodeifian et al. (models I-II), Bartle et al., Bian et al., Sung-Shim, Mendez-Santiago-Teja and Peng-Robinson EoS with van der Waals mixing rule. Among which the Bian et al., model and Peng-Robinson EoS showed the minimum AARD% of about 4.45 % (corresponding corrected Akaike Information Criterion is −704.09) and 7.54 % (corresponding corrected Akaike Information Criterion is −699.24), respectively. Finally, enthalpies for the binary mixture of Niclosamide piperazine-supercritical carbon dioxide binary system has been determined, for the first time. |
| format | Article |
| id | doaj-art-55ee213f06c344f1b6338577fbbd1986 |
| institution | Kabale University |
| issn | 2212-9839 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of CO2 Utilization |
| spelling | doaj-art-55ee213f06c344f1b6338577fbbd19862025-01-13T04:18:49ZengElsevierJournal of CO2 Utilization2212-98392025-01-0191102995Niclosamide piperazine solubility in supercritical CO2 green solvent: A comprehensive experimental and modeling investigationGholamhossein Sodeifian0Hamidreza Bagheri1Farnoush Masihpour2Negar Rajaei3Maryam Arbab Nooshabadi4Department of Chemical Engineering, Faculty of Engineering, University of Kashan, Kashan 87317-53153, Iran; Laboratory of Supercritical Fluids and Nanotechnology, University of Kashan, Kashan 87317-53153, Iran; Modeling and Simulation Centre, Faculty of Engineering, University of Kashan, Kashan 87317-53153, Iran; Corresponding author at: Department of Chemical Engineering, Faculty of Engineering, University of Kashan, Kashan 87317-53153, Iran.Department of Chemical Engineering, Faculty of Engineering, Shahid Bahonar University of Kerman, Kerman 76188-68366, IranLaboratory of Supercritical Fluids and Nanotechnology, University of Kashan, Kashan 87317-53153, Iran; Modeling and Simulation Centre, Faculty of Engineering, University of Kashan, Kashan 87317-53153, IranLaboratory of Supercritical Fluids and Nanotechnology, University of Kashan, Kashan 87317-53153, Iran; Modeling and Simulation Centre, Faculty of Engineering, University of Kashan, Kashan 87317-53153, IranBolvar Ghotbe Ravandi, Kashan Branch, Islamic Azad University, Ostaadan Street, Kashan 87159-98151, IranIn order to micro and Nano sizing a drug via supercritical fluid technology, it is necessary to obtain its solubility in various ranges of pressures and temperatures. For this purpose, solubility of Niclosamide piperazine, in supercritical carbon dioxide (SC-CO2) was measured by a new static method, for the first time. The measurements were performed at various circumstances, i.e. temperatures = 308, 318, 328 and 338 K and pressures = 12–27 MPa. The obtained results indicate that pressure significantly influences the solubility of Niclosamide piperazine, with a measured solubility ranging from 0.77 × 10−7 to 13.60 × 10−7 in mole fraction. To study theoretically the solubility of Niclosamide piperazine, the obtained results are modeled using nine semi-empirical equations i.e. Garlapati-Madras, Chrastil, Kumar-Johnston, Sodeifian et al. (models I-II), Bartle et al., Bian et al., Sung-Shim, Mendez-Santiago-Teja and Peng-Robinson EoS with van der Waals mixing rule. Among which the Bian et al., model and Peng-Robinson EoS showed the minimum AARD% of about 4.45 % (corresponding corrected Akaike Information Criterion is −704.09) and 7.54 % (corresponding corrected Akaike Information Criterion is −699.24), respectively. Finally, enthalpies for the binary mixture of Niclosamide piperazine-supercritical carbon dioxide binary system has been determined, for the first time.http://www.sciencedirect.com/science/article/pii/S2212982024003305Niclosamide piperazineDrugVan der Waals mixing rulePeng-RobinsonSemi-empiricalSolubility |
| spellingShingle | Gholamhossein Sodeifian Hamidreza Bagheri Farnoush Masihpour Negar Rajaei Maryam Arbab Nooshabadi Niclosamide piperazine solubility in supercritical CO2 green solvent: A comprehensive experimental and modeling investigation Journal of CO2 Utilization Niclosamide piperazine Drug Van der Waals mixing rule Peng-Robinson Semi-empirical Solubility |
| title | Niclosamide piperazine solubility in supercritical CO2 green solvent: A comprehensive experimental and modeling investigation |
| title_full | Niclosamide piperazine solubility in supercritical CO2 green solvent: A comprehensive experimental and modeling investigation |
| title_fullStr | Niclosamide piperazine solubility in supercritical CO2 green solvent: A comprehensive experimental and modeling investigation |
| title_full_unstemmed | Niclosamide piperazine solubility in supercritical CO2 green solvent: A comprehensive experimental and modeling investigation |
| title_short | Niclosamide piperazine solubility in supercritical CO2 green solvent: A comprehensive experimental and modeling investigation |
| title_sort | niclosamide piperazine solubility in supercritical co2 green solvent a comprehensive experimental and modeling investigation |
| topic | Niclosamide piperazine Drug Van der Waals mixing rule Peng-Robinson Semi-empirical Solubility |
| url | http://www.sciencedirect.com/science/article/pii/S2212982024003305 |
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