Reinfusion of peritoneal fluid elevates the level of plasma D‐dimer in patients with early‐onset ovarian hyperstimulation syndrome
Abstract Purpose This study aimed to elucidate the factors that affect the dynamics of blood D‐dimer in ovarian hyperstimulation syndrome (OHSS). Methods We retrospectively reviewed medical records from two hospitals and extracted data obtained during assisted reproductive technology and OHSS treatm...
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| Format: | Article |
| Language: | English |
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Wiley
2024-01-01
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| Series: | Reproductive Medicine and Biology |
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| Online Access: | https://doi.org/10.1002/rmb2.12563 |
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| author | Shiori Kumazawa Kazuki Saito Nanako Hashido Rinko Ibi Tomonori Ishikawa Akira Wakabayashi Naoyuki Miyasaka |
| author_facet | Shiori Kumazawa Kazuki Saito Nanako Hashido Rinko Ibi Tomonori Ishikawa Akira Wakabayashi Naoyuki Miyasaka |
| author_sort | Shiori Kumazawa |
| collection | DOAJ |
| description | Abstract Purpose This study aimed to elucidate the factors that affect the dynamics of blood D‐dimer in ovarian hyperstimulation syndrome (OHSS). Methods We retrospectively reviewed medical records from two hospitals and extracted data obtained during assisted reproductive technology and OHSS treatment. Blood D‐dimer levels during hospitalization were plotted against body weight. Other factors possibly related to blood D‐dimer levels were also analyzed. Results The analysis included 10 patients with OHSS admitted between January 2013 and June 2023. In all patients, blood D‐dimer levels increased significantly when they convalesced from OHSS and lost weight. None of the patients showed clinical signs of thrombosis, which was confirmed using imaging tests in 8 of 10 patients. Two patients underwent cell‐free and concentrated ascites reinfusion therapy (CART), and their blood D‐dimer levels increased dramatically after the procedure. Conclusion Weight change and CART are associated with blood D‐dimer dynamics in OHSS. Our results show that elevated blood D‐dimer levels in patients with OHSS do not always represent the presence of thrombosis. Reinfusion of pooled D‐dimer in ascites may explain the D‐dimer surge during the recovery phase or after CART in these patients. Our study provides new perspectives on the clinical implications of D‐dimer during OHSS. |
| format | Article |
| id | doaj-art-55d82162f66440c0992b22edbc81c0fb |
| institution | Kabale University |
| issn | 1445-5781 1447-0578 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Reproductive Medicine and Biology |
| spelling | doaj-art-55d82162f66440c0992b22edbc81c0fb2024-12-20T06:08:38ZengWileyReproductive Medicine and Biology1445-57811447-05782024-01-01231n/an/a10.1002/rmb2.12563Reinfusion of peritoneal fluid elevates the level of plasma D‐dimer in patients with early‐onset ovarian hyperstimulation syndromeShiori Kumazawa0Kazuki Saito1Nanako Hashido2Rinko Ibi3Tomonori Ishikawa4Akira Wakabayashi5Naoyuki Miyasaka6Department of Comprehensive Reproductive Medicine, Graduate School Tokyo Medical and Dental University Tokyo JapanDepartment of Perinatal and Maternal Medicine (Ibaraki), Graduate School Tokyo Medical and Dental University Tokyo JapanDepartment of Comprehensive Reproductive Medicine, Graduate School Tokyo Medical and Dental University Tokyo JapanDepartment of Obstetrics and Gynecology Tokyo Metropolitan Hiroo Hospital Tokyo JapanDepartment of Perinatal and Maternal Medicine (Ibaraki), Graduate School Tokyo Medical and Dental University Tokyo JapanDepartment of Obstetrics and Gynecology Tokyo Metropolitan Hiroo Hospital Tokyo JapanDepartment of Comprehensive Reproductive Medicine, Graduate School Tokyo Medical and Dental University Tokyo JapanAbstract Purpose This study aimed to elucidate the factors that affect the dynamics of blood D‐dimer in ovarian hyperstimulation syndrome (OHSS). Methods We retrospectively reviewed medical records from two hospitals and extracted data obtained during assisted reproductive technology and OHSS treatment. Blood D‐dimer levels during hospitalization were plotted against body weight. Other factors possibly related to blood D‐dimer levels were also analyzed. Results The analysis included 10 patients with OHSS admitted between January 2013 and June 2023. In all patients, blood D‐dimer levels increased significantly when they convalesced from OHSS and lost weight. None of the patients showed clinical signs of thrombosis, which was confirmed using imaging tests in 8 of 10 patients. Two patients underwent cell‐free and concentrated ascites reinfusion therapy (CART), and their blood D‐dimer levels increased dramatically after the procedure. Conclusion Weight change and CART are associated with blood D‐dimer dynamics in OHSS. Our results show that elevated blood D‐dimer levels in patients with OHSS do not always represent the presence of thrombosis. Reinfusion of pooled D‐dimer in ascites may explain the D‐dimer surge during the recovery phase or after CART in these patients. Our study provides new perspectives on the clinical implications of D‐dimer during OHSS.https://doi.org/10.1002/rmb2.12563D‐dimerovarian hyperstimulation syndromeperitoneal effusionVEGFvenous thromboembolism |
| spellingShingle | Shiori Kumazawa Kazuki Saito Nanako Hashido Rinko Ibi Tomonori Ishikawa Akira Wakabayashi Naoyuki Miyasaka Reinfusion of peritoneal fluid elevates the level of plasma D‐dimer in patients with early‐onset ovarian hyperstimulation syndrome Reproductive Medicine and Biology D‐dimer ovarian hyperstimulation syndrome peritoneal effusion VEGF venous thromboembolism |
| title | Reinfusion of peritoneal fluid elevates the level of plasma D‐dimer in patients with early‐onset ovarian hyperstimulation syndrome |
| title_full | Reinfusion of peritoneal fluid elevates the level of plasma D‐dimer in patients with early‐onset ovarian hyperstimulation syndrome |
| title_fullStr | Reinfusion of peritoneal fluid elevates the level of plasma D‐dimer in patients with early‐onset ovarian hyperstimulation syndrome |
| title_full_unstemmed | Reinfusion of peritoneal fluid elevates the level of plasma D‐dimer in patients with early‐onset ovarian hyperstimulation syndrome |
| title_short | Reinfusion of peritoneal fluid elevates the level of plasma D‐dimer in patients with early‐onset ovarian hyperstimulation syndrome |
| title_sort | reinfusion of peritoneal fluid elevates the level of plasma d dimer in patients with early onset ovarian hyperstimulation syndrome |
| topic | D‐dimer ovarian hyperstimulation syndrome peritoneal effusion VEGF venous thromboembolism |
| url | https://doi.org/10.1002/rmb2.12563 |
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