Calycosin-7-O-β-D-glucoside Attenuates OGD/R-Induced Damage by Preventing Oxidative Stress and Neuronal Apoptosis via the SIRT1/FOXO1/PGC-1α Pathway in HT22 Cells

Calycosin-7-O-β-D-glucoside Attenuates OGD/R-Induced Damage by Preventing Oxidative Stress and Neuronal Apoptosis via the SIRT1/FOXO1/PGC-1α Pathway in HT22 Cells

Neuronal apoptosis induced by oxidative stress is a major pathological process that occurs after cerebral ischemia-reperfusion. Calycosin-7-O-β-D-glucoside (CG) is a representative component of isoflavones in Radix Astragali (RA). Previous studies have shown that CG has potential neuroprotective eff...

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Bibliographic Details
Main Authors: Xiangli Yan, Aiming Yu, Haozhen Zheng, Shengxin Wang, Yingying He, Lisheng Wang
Format: Article
Language:English
Published: Wiley 2019-01-01
Series:Neural Plasticity
Online Access:http://dx.doi.org/10.1155/2019/8798069
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http://dx.doi.org/10.1155/2019/8798069

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