Progressive multifocal leukoencephalopathy, the role of the susceptibility-weighted imaging sequence in a case of immunosuppression of an initially unknown cause
We describe the case of a 47-year-old woman who was confused and complained about left-sided weakness when she presented to our institution. The patient underwent a head computed tomography that raised the suspicion of a recent-onset ischemic episode (subacute phase). The patient was admitted to the...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Korean Encephalitis and Neuroinflammation Society
2025-01-01
|
| Series: | Encephalitis |
| Subjects: | |
| Online Access: | http://encephalitisjournal.org/upload/pdf/encephalitis-2024-00094.pdf |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1841550840719998976 |
|---|---|
| author | Giuseppe Maria Andrea D’Arma Rosario Francesco Balzano Federica Masino Giuseppe Guglielmi |
| author_facet | Giuseppe Maria Andrea D’Arma Rosario Francesco Balzano Federica Masino Giuseppe Guglielmi |
| author_sort | Giuseppe Maria Andrea D’Arma |
| collection | DOAJ |
| description | We describe the case of a 47-year-old woman who was confused and complained about left-sided weakness when she presented to our institution. The patient underwent a head computed tomography that raised the suspicion of a recent-onset ischemic episode (subacute phase). The patient was admitted to the neurology department and underwent a magnetic resonance imaging (MRI) with contrast medium administration. The clinical and laboratory findings and the MRI features, particularly the presence of a hypointense rim in the susceptibility-weighted imaging (SWI) sequences, were consistent with a diagnosis of progressive multifocal leukoencephalopathy (PML). Immunosuppression was observed as a result of lymphopenia, and the patient was subsequently diagnosed with previously undocumented AIDS. Our aim is to present this rare case of PML in an immunocompromised patient with AIDS, describing the main MRI features and the possible role of SWI sequences. |
| format | Article |
| id | doaj-art-5596000dcea14fd2a7c780e5e5887527 |
| institution | Kabale University |
| issn | 2765-4559 2734-1461 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Korean Encephalitis and Neuroinflammation Society |
| record_format | Article |
| series | Encephalitis |
| spelling | doaj-art-5596000dcea14fd2a7c780e5e58875272025-01-09T23:24:29ZengKorean Encephalitis and Neuroinflammation SocietyEncephalitis2765-45592734-14612025-01-0151152010.47936/encephalitis.2024.0009480Progressive multifocal leukoencephalopathy, the role of the susceptibility-weighted imaging sequence in a case of immunosuppression of an initially unknown causeGiuseppe Maria Andrea D’Arma0Rosario Francesco Balzano1Federica Masino2Giuseppe Guglielmi3 Department of Clinical and Experimental Medicine, Foggia University School of Medicine, Foggia, Italy Radiology Unit, Dimiccoli Hospital, Barletta, Italy Department of Clinical and Experimental Medicine, Foggia University School of Medicine, Foggia, Italy Department of Clinical and Experimental Medicine, Foggia University School of Medicine, Foggia, ItalyWe describe the case of a 47-year-old woman who was confused and complained about left-sided weakness when she presented to our institution. The patient underwent a head computed tomography that raised the suspicion of a recent-onset ischemic episode (subacute phase). The patient was admitted to the neurology department and underwent a magnetic resonance imaging (MRI) with contrast medium administration. The clinical and laboratory findings and the MRI features, particularly the presence of a hypointense rim in the susceptibility-weighted imaging (SWI) sequences, were consistent with a diagnosis of progressive multifocal leukoencephalopathy (PML). Immunosuppression was observed as a result of lymphopenia, and the patient was subsequently diagnosed with previously undocumented AIDS. Our aim is to present this rare case of PML in an immunocompromised patient with AIDS, describing the main MRI features and the possible role of SWI sequences.http://encephalitisjournal.org/upload/pdf/encephalitis-2024-00094.pdfmagnetic resonance imagingneuroimagingprogressive multifocal leukoencephalopathysusceptibility-weighted imaging sequencejc virus |
| spellingShingle | Giuseppe Maria Andrea D’Arma Rosario Francesco Balzano Federica Masino Giuseppe Guglielmi Progressive multifocal leukoencephalopathy, the role of the susceptibility-weighted imaging sequence in a case of immunosuppression of an initially unknown cause Encephalitis magnetic resonance imaging neuroimaging progressive multifocal leukoencephalopathy susceptibility-weighted imaging sequence jc virus |
| title | Progressive multifocal leukoencephalopathy, the role of the susceptibility-weighted imaging sequence in a case of immunosuppression of an initially unknown cause |
| title_full | Progressive multifocal leukoencephalopathy, the role of the susceptibility-weighted imaging sequence in a case of immunosuppression of an initially unknown cause |
| title_fullStr | Progressive multifocal leukoencephalopathy, the role of the susceptibility-weighted imaging sequence in a case of immunosuppression of an initially unknown cause |
| title_full_unstemmed | Progressive multifocal leukoencephalopathy, the role of the susceptibility-weighted imaging sequence in a case of immunosuppression of an initially unknown cause |
| title_short | Progressive multifocal leukoencephalopathy, the role of the susceptibility-weighted imaging sequence in a case of immunosuppression of an initially unknown cause |
| title_sort | progressive multifocal leukoencephalopathy the role of the susceptibility weighted imaging sequence in a case of immunosuppression of an initially unknown cause |
| topic | magnetic resonance imaging neuroimaging progressive multifocal leukoencephalopathy susceptibility-weighted imaging sequence jc virus |
| url | http://encephalitisjournal.org/upload/pdf/encephalitis-2024-00094.pdf |
| work_keys_str_mv | AT giuseppemariaandreadarma progressivemultifocalleukoencephalopathytheroleofthesusceptibilityweightedimagingsequenceinacaseofimmunosuppressionofaninitiallyunknowncause AT rosariofrancescobalzano progressivemultifocalleukoencephalopathytheroleofthesusceptibilityweightedimagingsequenceinacaseofimmunosuppressionofaninitiallyunknowncause AT federicamasino progressivemultifocalleukoencephalopathytheroleofthesusceptibilityweightedimagingsequenceinacaseofimmunosuppressionofaninitiallyunknowncause AT giuseppeguglielmi progressivemultifocalleukoencephalopathytheroleofthesusceptibilityweightedimagingsequenceinacaseofimmunosuppressionofaninitiallyunknowncause |