Hydroxytyrosol: A Promising Therapeutic Agent for Mitigating Inflammation and Apoptosis
Inflammation and apoptosis are interrelated biological processes that have a significant impact on the advancement and growth of certain chronic diseases, such as cardiovascular problems, neurological conditions, and osteoarthritis. Recent research has emphasized that focusing on these mechanisms co...
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2024-11-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/16/12/1504 |
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| author | Wafa Ali Batarfi Mohd Heikal Mohd Yunus Adila A. Hamid Yi Ting Lee Manira Maarof |
| author_facet | Wafa Ali Batarfi Mohd Heikal Mohd Yunus Adila A. Hamid Yi Ting Lee Manira Maarof |
| author_sort | Wafa Ali Batarfi |
| collection | DOAJ |
| description | Inflammation and apoptosis are interrelated biological processes that have a significant impact on the advancement and growth of certain chronic diseases, such as cardiovascular problems, neurological conditions, and osteoarthritis. Recent research has emphasized that focusing on these mechanisms could result in novel therapeutic approaches that aim to decrease the severity of diseases and enhance patient outcomes. Hydroxytyrosol (HT), which is well-known for its ability to prevent oxidation, has been identified as a possible candidate for regulating both inflammation and apoptosis. In this review, we will highlight the multifaceted benefits of HT as a therapeutic agent in mitigating inflammation, apoptosis, and associated conditions. This review provides a comprehensive overview of the latest in vitro and in vivo research on the anti-inflammatory and antiapoptotic effects of HT and the mechanisms by which it works. Based on these studies, it is strongly advised to use HT as a bioactive ingredient in pharmaceutical products intended for mitigating inflammation, as well as those with apoptosis applications. |
| format | Article |
| id | doaj-art-5591fbcdbc9b4eac862d2bc34dd9bce3 |
| institution | Kabale University |
| issn | 1999-4923 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj-art-5591fbcdbc9b4eac862d2bc34dd9bce32024-12-27T14:46:19ZengMDPI AGPharmaceutics1999-49232024-11-011612150410.3390/pharmaceutics16121504Hydroxytyrosol: A Promising Therapeutic Agent for Mitigating Inflammation and ApoptosisWafa Ali Batarfi0Mohd Heikal Mohd Yunus1Adila A. Hamid2Yi Ting Lee3Manira Maarof4Department of Physiology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Yaacob Latiff, Bandar Tun Razak, Kuala Lumpur 56000, MalaysiaDepartment of Physiology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Yaacob Latiff, Bandar Tun Razak, Kuala Lumpur 56000, MalaysiaDepartment of Physiology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Yaacob Latiff, Bandar Tun Razak, Kuala Lumpur 56000, MalaysiaDepartment of Physiology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Yaacob Latiff, Bandar Tun Razak, Kuala Lumpur 56000, MalaysiaDepartment of Tissue Engineering and Regenerative Medicine, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Yaacob Latiff, Bandar Tun Razak, Kuala Lumpur 56000, MalaysiaInflammation and apoptosis are interrelated biological processes that have a significant impact on the advancement and growth of certain chronic diseases, such as cardiovascular problems, neurological conditions, and osteoarthritis. Recent research has emphasized that focusing on these mechanisms could result in novel therapeutic approaches that aim to decrease the severity of diseases and enhance patient outcomes. Hydroxytyrosol (HT), which is well-known for its ability to prevent oxidation, has been identified as a possible candidate for regulating both inflammation and apoptosis. In this review, we will highlight the multifaceted benefits of HT as a therapeutic agent in mitigating inflammation, apoptosis, and associated conditions. This review provides a comprehensive overview of the latest in vitro and in vivo research on the anti-inflammatory and antiapoptotic effects of HT and the mechanisms by which it works. Based on these studies, it is strongly advised to use HT as a bioactive ingredient in pharmaceutical products intended for mitigating inflammation, as well as those with apoptosis applications.https://www.mdpi.com/1999-4923/16/12/1504hydroxytyrosolinflammationapoptosisnatural products |
| spellingShingle | Wafa Ali Batarfi Mohd Heikal Mohd Yunus Adila A. Hamid Yi Ting Lee Manira Maarof Hydroxytyrosol: A Promising Therapeutic Agent for Mitigating Inflammation and Apoptosis Pharmaceutics hydroxytyrosol inflammation apoptosis natural products |
| title | Hydroxytyrosol: A Promising Therapeutic Agent for Mitigating Inflammation and Apoptosis |
| title_full | Hydroxytyrosol: A Promising Therapeutic Agent for Mitigating Inflammation and Apoptosis |
| title_fullStr | Hydroxytyrosol: A Promising Therapeutic Agent for Mitigating Inflammation and Apoptosis |
| title_full_unstemmed | Hydroxytyrosol: A Promising Therapeutic Agent for Mitigating Inflammation and Apoptosis |
| title_short | Hydroxytyrosol: A Promising Therapeutic Agent for Mitigating Inflammation and Apoptosis |
| title_sort | hydroxytyrosol a promising therapeutic agent for mitigating inflammation and apoptosis |
| topic | hydroxytyrosol inflammation apoptosis natural products |
| url | https://www.mdpi.com/1999-4923/16/12/1504 |
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