Intestinal rearrangement of biliopancreatic limbs, alimentary limbs, and common limbs in obese type 2 diabetic mice after duodenal jejunal bypass surgery
Bariatric surgery is an effective treatment for type 2 Diabetes Mellitus (T2DM), yet the precise mechanisms underlying its effectiveness remain incompletely understood. While previous research has emphasized the role of rearrangement of the gastrointestinal anatomy, gaps persist regarding the specif...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2024.1456885/full |
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| author | Heng Li Heng Li Jipei He Jie Hou Chengjun He Xiaojiang Dai Zhigao Song Qing Liu Zixin Wang Hongyan Huang Yunfa Ding Tengfei Qi Hongbin Zhang Hongbin Zhang Liangping Wu Liangping Wu |
| author_facet | Heng Li Heng Li Jipei He Jie Hou Chengjun He Xiaojiang Dai Zhigao Song Qing Liu Zixin Wang Hongyan Huang Yunfa Ding Tengfei Qi Hongbin Zhang Hongbin Zhang Liangping Wu Liangping Wu |
| author_sort | Heng Li |
| collection | DOAJ |
| description | Bariatric surgery is an effective treatment for type 2 Diabetes Mellitus (T2DM), yet the precise mechanisms underlying its effectiveness remain incompletely understood. While previous research has emphasized the role of rearrangement of the gastrointestinal anatomy, gaps persist regarding the specific impact on the gut microbiota and barriers within the biliopancreatic, alimentary, and common limbs. This study aimed to investigate the effects of duodenal-jejunal bypass (DJB) surgery on obese T2DM mice. We performed DJB and SHAM surgery in obese T2DM mice to investigate changes in the gut microbiota and barrier across different intestinal limbs. The effects on serum metabolism and potential associations with T2DM improvement were also investigated. Following DJB surgery, there was an increased abundance of commensals across various limbs. Additionally, the surgery improved intestinal permeability and inflammation in the alimentary and common limbs, while reducing inflammation in the biliopancreatic limbs. Furthermore, DJB surgery also improved T2DM by increasing L-glutamine, short-chain fatty acids, and bile acids and decreasing branched-chain amino acids. This study underscores the role of intestinal rearrangement in reshaping gut microbiota composition and enhancing gut barrier function, thereby contributing to the amelioration of T2DM following bariatric surgery, and providing new insights for further research on bariatric surgery. |
| format | Article |
| id | doaj-art-558393d32dff48019440a6b5169550d9 |
| institution | Kabale University |
| issn | 1664-2392 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj-art-558393d32dff48019440a6b5169550d92025-01-08T05:10:28ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922025-01-011510.3389/fendo.2024.14568851456885Intestinal rearrangement of biliopancreatic limbs, alimentary limbs, and common limbs in obese type 2 diabetic mice after duodenal jejunal bypass surgeryHeng Li0Heng Li1Jipei He2Jie Hou3Chengjun He4Xiaojiang Dai5Zhigao Song6Qing Liu7Zixin Wang8Hongyan Huang9Yunfa Ding10Tengfei Qi11Hongbin Zhang12Hongbin Zhang13Liangping Wu14Liangping Wu15Department of Metabolic Surgery, Jinshazhou Hospital of Guangzhou University of Chinese Medicine, Guangzhou, ChinaDepartment of Endocrinology and Metabolism, Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, ChinaDepartment of Basic Medical Research, General Hospital of Southern Theater Command of People's Liberation Army (PLA), Guangzhou, ChinaDepartment of Metabolic Surgery, Jinshazhou Hospital of Guangzhou University of Chinese Medicine, Guangzhou, ChinaDepartment of Metabolic Surgery, Jinshazhou Hospital of Guangzhou University of Chinese Medicine, Guangzhou, ChinaDepartment of Metabolic Surgery, Jinshazhou Hospital of Guangzhou University of Chinese Medicine, Guangzhou, ChinaDepartment of Cardiovascular Surgery, Zhujiang Hospital of Southern Medical University, Guangzhou, ChinaZhongshan Institute for Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Guangzhou, ChinaDepartment of Metabolic Surgery, Jinshazhou Hospital of Guangzhou University of Chinese Medicine, Guangzhou, ChinaDepartment of Metabolic Surgery, Jinshazhou Hospital of Guangzhou University of Chinese Medicine, Guangzhou, ChinaDepartment of Metabolic Surgery, Jinshazhou Hospital of Guangzhou University of Chinese Medicine, Guangzhou, ChinaDepartment of Metabolic Surgery, Jinshazhou Hospital of Guangzhou University of Chinese Medicine, Guangzhou, ChinaDepartment of Basic Medical Research, General Hospital of Southern Theater Command of People's Liberation Army (PLA), Guangzhou, ChinaSchool of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou, ChinaDepartment of Metabolic Surgery, Jinshazhou Hospital of Guangzhou University of Chinese Medicine, Guangzhou, ChinaGuangzhou Hualiang Qingying Biotechnology Co. Ltd, Guangzhou, ChinaBariatric surgery is an effective treatment for type 2 Diabetes Mellitus (T2DM), yet the precise mechanisms underlying its effectiveness remain incompletely understood. While previous research has emphasized the role of rearrangement of the gastrointestinal anatomy, gaps persist regarding the specific impact on the gut microbiota and barriers within the biliopancreatic, alimentary, and common limbs. This study aimed to investigate the effects of duodenal-jejunal bypass (DJB) surgery on obese T2DM mice. We performed DJB and SHAM surgery in obese T2DM mice to investigate changes in the gut microbiota and barrier across different intestinal limbs. The effects on serum metabolism and potential associations with T2DM improvement were also investigated. Following DJB surgery, there was an increased abundance of commensals across various limbs. Additionally, the surgery improved intestinal permeability and inflammation in the alimentary and common limbs, while reducing inflammation in the biliopancreatic limbs. Furthermore, DJB surgery also improved T2DM by increasing L-glutamine, short-chain fatty acids, and bile acids and decreasing branched-chain amino acids. This study underscores the role of intestinal rearrangement in reshaping gut microbiota composition and enhancing gut barrier function, thereby contributing to the amelioration of T2DM following bariatric surgery, and providing new insights for further research on bariatric surgery.https://www.frontiersin.org/articles/10.3389/fendo.2024.1456885/fullduodenal jejunal bypasstype 2 diabetes mellitusgut microbiotagut barriermetabonomicsbariatric surgery |
| spellingShingle | Heng Li Heng Li Jipei He Jie Hou Chengjun He Xiaojiang Dai Zhigao Song Qing Liu Zixin Wang Hongyan Huang Yunfa Ding Tengfei Qi Hongbin Zhang Hongbin Zhang Liangping Wu Liangping Wu Intestinal rearrangement of biliopancreatic limbs, alimentary limbs, and common limbs in obese type 2 diabetic mice after duodenal jejunal bypass surgery Frontiers in Endocrinology duodenal jejunal bypass type 2 diabetes mellitus gut microbiota gut barrier metabonomics bariatric surgery |
| title | Intestinal rearrangement of biliopancreatic limbs, alimentary limbs, and common limbs in obese type 2 diabetic mice after duodenal jejunal bypass surgery |
| title_full | Intestinal rearrangement of biliopancreatic limbs, alimentary limbs, and common limbs in obese type 2 diabetic mice after duodenal jejunal bypass surgery |
| title_fullStr | Intestinal rearrangement of biliopancreatic limbs, alimentary limbs, and common limbs in obese type 2 diabetic mice after duodenal jejunal bypass surgery |
| title_full_unstemmed | Intestinal rearrangement of biliopancreatic limbs, alimentary limbs, and common limbs in obese type 2 diabetic mice after duodenal jejunal bypass surgery |
| title_short | Intestinal rearrangement of biliopancreatic limbs, alimentary limbs, and common limbs in obese type 2 diabetic mice after duodenal jejunal bypass surgery |
| title_sort | intestinal rearrangement of biliopancreatic limbs alimentary limbs and common limbs in obese type 2 diabetic mice after duodenal jejunal bypass surgery |
| topic | duodenal jejunal bypass type 2 diabetes mellitus gut microbiota gut barrier metabonomics bariatric surgery |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2024.1456885/full |
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