Diverse Cytokines Secreted by Adipocyte in Linking Cardio-Metabolic Disorder and SLE
Systemic lupus erythematosus (SLE) is a multi-factorial autoimmune-mediated disease with hyper-stimulation of immune cells especially the T lymphocytes. By this method, it might facilitate the systematic damages in multiple tissues and organs. Otherwise, SLE is also correlated with diverse cardio-me...
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IMR Press
2024-10-01
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| Series: | Frontiers in Bioscience-Landmark |
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| Online Access: | https://www.imrpress.com/journal/FBL/29/11/10.31083/j.fbl2911373 |
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| author | Min Lai Kai Lin Xiaofang Chen Ye Cheng |
| author_facet | Min Lai Kai Lin Xiaofang Chen Ye Cheng |
| author_sort | Min Lai |
| collection | DOAJ |
| description | Systemic lupus erythematosus (SLE) is a multi-factorial autoimmune-mediated disease with hyper-stimulation of immune cells especially the T lymphocytes. By this method, it might facilitate the systematic damages in multiple tissues and organs. Otherwise, SLE is also correlated with diverse cardio-metabolic comorbidities, including dyslipidemia, insulin resistance, and hypertension. It is worth-noting that the risk of cardio-metabolic disorders is significantly higher compared with the healthy patients which was reported as approximately one-third of SLE patients were proved as obesity. Notably, current focus is shifting to implementing cardio-metabolic protective strategies as well as elucidating underlying mechanisms of lupus-mediated obese status. On the other hand, adipocyte, as the most abundant endocrine cell in fat tissue, are dysfunctional in obese individuals with aberrant secretion of adipokines. It is proposing that the adipokine might link the pathology of cardio-metabolic disorders and SLE, whereas the related mechanism is complicated. In the current review, the functions of adipokine and the potential mechanisms by which the adipokine link cardio-metabolic disorders and SLE was well listed. Furthermore, the recommendations, which identify the adipokine as the potential therapeutic targets for the treatment of cardio-metabolic disorders and SLE, were also summarized. |
| format | Article |
| id | doaj-art-554fea7687d549f7976515f5a47a7bef |
| institution | Kabale University |
| issn | 2768-6701 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | IMR Press |
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| series | Frontiers in Bioscience-Landmark |
| spelling | doaj-art-554fea7687d549f7976515f5a47a7bef2024-11-30T05:06:31ZengIMR PressFrontiers in Bioscience-Landmark2768-67012024-10-01291137310.31083/j.fbl2911373S2768-6701(24)01509-0Diverse Cytokines Secreted by Adipocyte in Linking Cardio-Metabolic Disorder and SLEMin Lai0Kai Lin1Xiaofang Chen2Ye Cheng3Department of Cardiology, The Xiamen Cardiovascular Hospital of Xiamen University, 361000 Xiamen, Fujian, ChinaDepartment of Interventional Clinic, The Xiamen Cardiovascular Hospital of Xiamen University, 361000 Xiamen, Fujian, ChinaDepartment of Cardiology, The Xiamen Cardiovascular Hospital of Xiamen University, 361000 Xiamen, Fujian, ChinaDepartment of Cardiology, The Xiamen Cardiovascular Hospital of Xiamen University, 361000 Xiamen, Fujian, ChinaSystemic lupus erythematosus (SLE) is a multi-factorial autoimmune-mediated disease with hyper-stimulation of immune cells especially the T lymphocytes. By this method, it might facilitate the systematic damages in multiple tissues and organs. Otherwise, SLE is also correlated with diverse cardio-metabolic comorbidities, including dyslipidemia, insulin resistance, and hypertension. It is worth-noting that the risk of cardio-metabolic disorders is significantly higher compared with the healthy patients which was reported as approximately one-third of SLE patients were proved as obesity. Notably, current focus is shifting to implementing cardio-metabolic protective strategies as well as elucidating underlying mechanisms of lupus-mediated obese status. On the other hand, adipocyte, as the most abundant endocrine cell in fat tissue, are dysfunctional in obese individuals with aberrant secretion of adipokines. It is proposing that the adipokine might link the pathology of cardio-metabolic disorders and SLE, whereas the related mechanism is complicated. In the current review, the functions of adipokine and the potential mechanisms by which the adipokine link cardio-metabolic disorders and SLE was well listed. Furthermore, the recommendations, which identify the adipokine as the potential therapeutic targets for the treatment of cardio-metabolic disorders and SLE, were also summarized.https://www.imrpress.com/journal/FBL/29/11/10.31083/j.fbl2911373systemic lupus erythematosuscardio-metabolic disordersinflammatory responseadipocytecytokine |
| spellingShingle | Min Lai Kai Lin Xiaofang Chen Ye Cheng Diverse Cytokines Secreted by Adipocyte in Linking Cardio-Metabolic Disorder and SLE Frontiers in Bioscience-Landmark systemic lupus erythematosus cardio-metabolic disorders inflammatory response adipocyte cytokine |
| title | Diverse Cytokines Secreted by Adipocyte in Linking Cardio-Metabolic Disorder and SLE |
| title_full | Diverse Cytokines Secreted by Adipocyte in Linking Cardio-Metabolic Disorder and SLE |
| title_fullStr | Diverse Cytokines Secreted by Adipocyte in Linking Cardio-Metabolic Disorder and SLE |
| title_full_unstemmed | Diverse Cytokines Secreted by Adipocyte in Linking Cardio-Metabolic Disorder and SLE |
| title_short | Diverse Cytokines Secreted by Adipocyte in Linking Cardio-Metabolic Disorder and SLE |
| title_sort | diverse cytokines secreted by adipocyte in linking cardio metabolic disorder and sle |
| topic | systemic lupus erythematosus cardio-metabolic disorders inflammatory response adipocyte cytokine |
| url | https://www.imrpress.com/journal/FBL/29/11/10.31083/j.fbl2911373 |
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