Population pharmacokinetic study of the effect of polymorphisms in the ABCB1 and CES1 genes on the pharmacokinetics of dabigatran

Population pharmacokinetic study of the effect of polymorphisms in the ABCB1 and CES1 genes on the pharmacokinetics of dabigatran

PurposeThe impact of genetic polymorphisms in the ABCB1 and CES1 genes on dabigatran plasma concentrations remains a subject of debate, and the purpose of this study was to quantitatively assess the effects of genetic polymorphisms on dabigatran esters in healthy Chinese subjects employed a populati...

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Bibliographic Details
Main Authors: Zhuan Yang, Wen Rui Tan, Qin Li, Ying Wang, Shijing Liu, Lu Chen, Yan Zhou, Chen Zeng, Yan Zeng, Yun Xiong, Qian Zhang, Na Li, Peng Du, Lin Liu, Jiyu Chen, Yan He
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-11-01
Series:Frontiers in Pharmacology
Subjects:
population pharmacokinetic
food effects
dabigatran
genetic polymorphism
ABCB1
CES1
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2024.1454612/full
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https://www.frontiersin.org/articles/10.3389/fphar.2024.1454612/full

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