Efficacy of Topical Corticosteroid vs PUVAsol Following Split Thickness Grafting in Stable Vitiligo: A Randomised Control Trial
Background: Vitiligo is a common, acquired, discoloration of the skin, characterized by well circumscribed, ivory or chalky white macules which are flush to the skin surface. Although majority of cases are managed by medical therapies, surgical methods are reserved for lesions not responding to medi...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2024-12-01
|
| Series: | Journal of Dermatology and Dermatologic Surgery |
| Subjects: | |
| Online Access: | https://journals.lww.com/10.4103/jdds.jdds_30_24 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1841556637896146944 |
|---|---|
| author | Prafull Mehta Chinmai Yadav Ramesh Kumar Suresh Jain |
| author_facet | Prafull Mehta Chinmai Yadav Ramesh Kumar Suresh Jain |
| author_sort | Prafull Mehta |
| collection | DOAJ |
| description | Background:
Vitiligo is a common, acquired, discoloration of the skin, characterized by well circumscribed, ivory or chalky white macules which are flush to the skin surface. Although majority of cases are managed by medical therapies, surgical methods are reserved for lesions not responding to medical treatment and are stable in nature. The basic principle surgical method is the transfer of melanocytes from uninvolved skin to the stable vitiligo patch in the form of either tissue graft or cellular graft.
Purpose:
To evaluate the effects of topical corticosteroids and PUVAsol in repigmentation of vitiligo patch following split-thickness skin grafting.
Methods:
Twenty patients of stable vitiligo having total 30 patches were included in the study of which 15 completed it. Each patch is subjected to split-thickness skin grafting and then randomly divided into two groups of fifteen each. Group A received PUVAsol therapy while other received topical steroid therapy started 4 weeks after surgery. During the follow-up of 6 months, five patients were lost to follow-up; fifteen patients were evaluated for pigment spread and side effects at 1st, 4th, 8th, and 24th week.
Results:
Eight patients (61.53%) in PUVA sol group and seven patients (58.3%) in steroid group had excellent (>90%). Color matching of grafted area was observed to be better with steroid therapy (83.3%), then PUVAsol (76.9%).
Conclusion:
Although the extent of repigmentation was more in Group A (PUVAsol) then in Group B, the color matching and the side effect profile were improved in Group B (topical steroid). The use of topical corticosteroid is much less cumbersome, cheaper, and easy to administer at home. The limitation of our study was short follow-up and small sample size. |
| format | Article |
| id | doaj-art-551a39ef6cfa47ba8900686662e9e7ca |
| institution | Kabale University |
| issn | 2352-2410 2352-2429 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Dermatology and Dermatologic Surgery |
| spelling | doaj-art-551a39ef6cfa47ba8900686662e9e7ca2025-01-07T06:53:11ZengWolters Kluwer Medknow PublicationsJournal of Dermatology and Dermatologic Surgery2352-24102352-24292024-12-01282949910.4103/jdds.jdds_30_24Efficacy of Topical Corticosteroid vs PUVAsol Following Split Thickness Grafting in Stable Vitiligo: A Randomised Control TrialPrafull MehtaChinmai YadavRamesh KumarSuresh JainBackground: Vitiligo is a common, acquired, discoloration of the skin, characterized by well circumscribed, ivory or chalky white macules which are flush to the skin surface. Although majority of cases are managed by medical therapies, surgical methods are reserved for lesions not responding to medical treatment and are stable in nature. The basic principle surgical method is the transfer of melanocytes from uninvolved skin to the stable vitiligo patch in the form of either tissue graft or cellular graft. Purpose: To evaluate the effects of topical corticosteroids and PUVAsol in repigmentation of vitiligo patch following split-thickness skin grafting. Methods: Twenty patients of stable vitiligo having total 30 patches were included in the study of which 15 completed it. Each patch is subjected to split-thickness skin grafting and then randomly divided into two groups of fifteen each. Group A received PUVAsol therapy while other received topical steroid therapy started 4 weeks after surgery. During the follow-up of 6 months, five patients were lost to follow-up; fifteen patients were evaluated for pigment spread and side effects at 1st, 4th, 8th, and 24th week. Results: Eight patients (61.53%) in PUVA sol group and seven patients (58.3%) in steroid group had excellent (>90%). Color matching of grafted area was observed to be better with steroid therapy (83.3%), then PUVAsol (76.9%). Conclusion: Although the extent of repigmentation was more in Group A (PUVAsol) then in Group B, the color matching and the side effect profile were improved in Group B (topical steroid). The use of topical corticosteroid is much less cumbersome, cheaper, and easy to administer at home. The limitation of our study was short follow-up and small sample size.https://journals.lww.com/10.4103/jdds.jdds_30_24puvasolrandomized control trialsplit-thickness skin graftingtopical steroid |
| spellingShingle | Prafull Mehta Chinmai Yadav Ramesh Kumar Suresh Jain Efficacy of Topical Corticosteroid vs PUVAsol Following Split Thickness Grafting in Stable Vitiligo: A Randomised Control Trial Journal of Dermatology and Dermatologic Surgery puvasol randomized control trial split-thickness skin grafting topical steroid |
| title | Efficacy of Topical Corticosteroid vs PUVAsol Following Split Thickness Grafting in Stable Vitiligo: A Randomised Control Trial |
| title_full | Efficacy of Topical Corticosteroid vs PUVAsol Following Split Thickness Grafting in Stable Vitiligo: A Randomised Control Trial |
| title_fullStr | Efficacy of Topical Corticosteroid vs PUVAsol Following Split Thickness Grafting in Stable Vitiligo: A Randomised Control Trial |
| title_full_unstemmed | Efficacy of Topical Corticosteroid vs PUVAsol Following Split Thickness Grafting in Stable Vitiligo: A Randomised Control Trial |
| title_short | Efficacy of Topical Corticosteroid vs PUVAsol Following Split Thickness Grafting in Stable Vitiligo: A Randomised Control Trial |
| title_sort | efficacy of topical corticosteroid vs puvasol following split thickness grafting in stable vitiligo a randomised control trial |
| topic | puvasol randomized control trial split-thickness skin grafting topical steroid |
| url | https://journals.lww.com/10.4103/jdds.jdds_30_24 |
| work_keys_str_mv | AT prafullmehta efficacyoftopicalcorticosteroidvspuvasolfollowingsplitthicknessgraftinginstablevitiligoarandomisedcontroltrial AT chinmaiyadav efficacyoftopicalcorticosteroidvspuvasolfollowingsplitthicknessgraftinginstablevitiligoarandomisedcontroltrial AT rameshkumar efficacyoftopicalcorticosteroidvspuvasolfollowingsplitthicknessgraftinginstablevitiligoarandomisedcontroltrial AT sureshjain efficacyoftopicalcorticosteroidvspuvasolfollowingsplitthicknessgraftinginstablevitiligoarandomisedcontroltrial |