CYP2C19 polymorphism and coronary in-stent restenosis: A systematic review and meta-analysis [version 3; peer review: 2 approved, 1 approved with reservations]
Background In-stent restenosis (ISR) remains a major drawback in coronary stenting. The association between the CYP2C19 loss of function (LOF) gene and the prevalence of ISR after coronary stenting remains controversial. Previous studies have produced conflicting results and have been limited by the...
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F1000 Research Ltd
2025-01-01
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| author | Ivana Purnama Dewi Irawan Yusuf Agussalim Bukhari Muzakkir Amir Vitriyaturrida . Yusra Pintaningrum Idar Mappangara Hendy Bhaskara Perdana Putra |
| author_facet | Ivana Purnama Dewi Irawan Yusuf Agussalim Bukhari Muzakkir Amir Vitriyaturrida . Yusra Pintaningrum Idar Mappangara Hendy Bhaskara Perdana Putra |
| author_sort | Ivana Purnama Dewi |
| collection | DOAJ |
| description | Background In-stent restenosis (ISR) remains a major drawback in coronary stenting. The association between the CYP2C19 loss of function (LOF) gene and the prevalence of ISR after coronary stenting remains controversial. Previous studies have produced conflicting results and have been limited by their small population sizes. We conducted this systematic review and meta-analysis to determine the association between the presence of the CYP2C19 LOF gene and the prevalence of ISR. Methods A systematic online database search was performed until April 2021. The primary outcome was ISR and assessed using OR with 95% CI. Quality of the study was assessed using the Newcastle Ottawa Scale. I2 was applied to examine heterogeneities among the studies. Results A total of 284 patients (four non-randomized controlled trial studies) were included in this study. Two hundred and six patients had wild-type genotypes, while 78 patients had the LOF genotype. Among the 78 patients with the LOF gene, 38 patients had an ISR. Meanwhile, of the 206 patients with a wild-type gene, 69 patients had an ISR. LOF gene was associated with a higher risk of ISR (OR 95% CI = 2.71 [1.42–5.16], P = 0.003). However, study-specific variability should be considered when applying these findings clinically. Conclusions Patients with LOF genes, regardless of the allele variation, treated with clopidogrel, had a higher likelihood of ISR after coronary stenting. |
| format | Article |
| id | doaj-art-54f9be2f4cb543d7880a11f6b32522a9 |
| institution | Kabale University |
| issn | 2046-1402 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | F1000 Research Ltd |
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| series | F1000Research |
| spelling | doaj-art-54f9be2f4cb543d7880a11f6b32522a92025-01-16T01:00:00ZengF1000 Research LtdF1000Research2046-14022025-01-0111176388CYP2C19 polymorphism and coronary in-stent restenosis: A systematic review and meta-analysis [version 3; peer review: 2 approved, 1 approved with reservations]Ivana Purnama Dewi0https://orcid.org/0000-0002-1602-3384Irawan Yusuf1Agussalim Bukhari2Muzakkir Amir3https://orcid.org/0000-0002-4914-3542Vitriyaturrida .4Yusra Pintaningrum5https://orcid.org/0000-0002-8843-4684Idar Mappangara6Hendy Bhaskara Perdana Putra7https://orcid.org/0000-0002-4231-1013Department of Cardiology and Vascular Medicine, Faculty of Medicine, Airlangga University - Dr Soetomo General Hospital, Surabaya, East Java, 60132, IndonesiaDepartment of Physiology, Faculty of Medicine, University of Hasanuddin, Makassar, South Sulawesi, 90245, IndonesiaDepartment of Nutrition, Faculty of Medicine, University of Hasanuddin, Makassar, South Sulawesi, 90245, IndonesiaDepartment of Cardiology and Vascular Medicine, Faculty of Medicine, University of Hasanuddin, Makasar, South Sulawesi, 90245, IndonesiaDepartment of Cardiology and Vascular Medicine, Slamet Martodirdjo General Hospital, Pamekasan, Madura, 69317, IndonesiaDepartment of Cardiology and Vascular Medicine, Faculty of Medicine, University of Mataram, Mataram, West Nusa Tenggara, 83126, IndonesiaDepartment of Cardiology and Vascular Medicine, Faculty of Medicine, University of Hasanuddin, Makasar, South Sulawesi, 90245, IndonesiaEmergency Department, dr. Ramelan Navy Hospital, Surabaya, East Java, 60244, IndonesiaBackground In-stent restenosis (ISR) remains a major drawback in coronary stenting. The association between the CYP2C19 loss of function (LOF) gene and the prevalence of ISR after coronary stenting remains controversial. Previous studies have produced conflicting results and have been limited by their small population sizes. We conducted this systematic review and meta-analysis to determine the association between the presence of the CYP2C19 LOF gene and the prevalence of ISR. Methods A systematic online database search was performed until April 2021. The primary outcome was ISR and assessed using OR with 95% CI. Quality of the study was assessed using the Newcastle Ottawa Scale. I2 was applied to examine heterogeneities among the studies. Results A total of 284 patients (four non-randomized controlled trial studies) were included in this study. Two hundred and six patients had wild-type genotypes, while 78 patients had the LOF genotype. Among the 78 patients with the LOF gene, 38 patients had an ISR. Meanwhile, of the 206 patients with a wild-type gene, 69 patients had an ISR. LOF gene was associated with a higher risk of ISR (OR 95% CI = 2.71 [1.42–5.16], P = 0.003). However, study-specific variability should be considered when applying these findings clinically. Conclusions Patients with LOF genes, regardless of the allele variation, treated with clopidogrel, had a higher likelihood of ISR after coronary stenting.https://f1000research.com/articles/11-346/v3CYP2C19 polymorphism coronary in-stent restenosis systematic review clopidogreleng |
| spellingShingle | Ivana Purnama Dewi Irawan Yusuf Agussalim Bukhari Muzakkir Amir Vitriyaturrida . Yusra Pintaningrum Idar Mappangara Hendy Bhaskara Perdana Putra CYP2C19 polymorphism and coronary in-stent restenosis: A systematic review and meta-analysis [version 3; peer review: 2 approved, 1 approved with reservations] F1000Research CYP2C19 polymorphism coronary in-stent restenosis systematic review clopidogrel eng |
| title | CYP2C19 polymorphism and coronary in-stent restenosis: A systematic review and meta-analysis [version 3; peer review: 2 approved, 1 approved with reservations] |
| title_full | CYP2C19 polymorphism and coronary in-stent restenosis: A systematic review and meta-analysis [version 3; peer review: 2 approved, 1 approved with reservations] |
| title_fullStr | CYP2C19 polymorphism and coronary in-stent restenosis: A systematic review and meta-analysis [version 3; peer review: 2 approved, 1 approved with reservations] |
| title_full_unstemmed | CYP2C19 polymorphism and coronary in-stent restenosis: A systematic review and meta-analysis [version 3; peer review: 2 approved, 1 approved with reservations] |
| title_short | CYP2C19 polymorphism and coronary in-stent restenosis: A systematic review and meta-analysis [version 3; peer review: 2 approved, 1 approved with reservations] |
| title_sort | cyp2c19 polymorphism and coronary in stent restenosis a systematic review and meta analysis version 3 peer review 2 approved 1 approved with reservations |
| topic | CYP2C19 polymorphism coronary in-stent restenosis systematic review clopidogrel eng |
| url | https://f1000research.com/articles/11-346/v3 |
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