Berberine promotes primordial follicle activation and increases ovulated oocyte quantity in aged mice

Berberine promotes primordial follicle activation and increases ovulated oocyte quantity in aged mice

Abstract Background Primordial follicle activation is vital for the reproduction of women with advanced age and premature ovarian insufficiency (POI). But there is a lack of effective and safe therapeutic options to activate their primordial follicles in vivo. Berberine (BBR) possesses multiple phar...

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Bibliographic Details
Main Authors: Shuang Liu, Weiyong Wang, Huiyu Liu, Hongwei Wei, Yashuang Weng, Wenjun Zhou, Xiaodan Zhang, Sihui He, Ye Chen, Yahong Wang, Meijia Zhang, Xin Chen
Format: Article
Language:English
Published: BMC 2024-12-01
Series:Molecular Medicine
Subjects:
Berberine
Primordial follicle activation
Akt
Premature ovarian insufficiency
Online Access:https://doi.org/10.1186/s10020-024-01042-z
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