Exploring the Relationship Between Hypertension and Cerebral Microvascular Disease
Background/Objectives: Hypertension exerts negative effects on the vasculature representing a key risk factor for cardiovascular disorders, cerebral and Cerebral Small Vessel Disease (CSVD). Methods: An extensive research in the literature was implemented in order to elucidate the role of hypertensi...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-10-01
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| Series: | Diseases |
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| Online Access: | https://www.mdpi.com/2079-9721/12/11/266 |
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| author | Vasiliki Katsi Andreas Mavroudis Ioannis Liatakis Manousiadis Konstantinos Konstantinos Tsioufis |
| author_facet | Vasiliki Katsi Andreas Mavroudis Ioannis Liatakis Manousiadis Konstantinos Konstantinos Tsioufis |
| author_sort | Vasiliki Katsi |
| collection | DOAJ |
| description | Background/Objectives: Hypertension exerts negative effects on the vasculature representing a key risk factor for cardiovascular disorders, cerebral and Cerebral Small Vessel Disease (CSVD). Methods: An extensive research in the literature was implemented in order to elucidate the role of hypertension in the pathogenesis of CSVD. Results: Hypertension-mediated vascular dysfunction and chronic cerebral hypoperfusion are closely linked to CSVD. CSVD encompasses a wide range of lesions depicted on brain Magnetic Resonance Imaging (MRI) or Computed Tomography (CT) scans. The presenting symptoms and clinical course are highly variable, as a significant proportion of patients remain asymptomatic. Nevertheless, CSVD is associated with an increased risk of stroke, dementia and mobility disorders. Various randomised controlled trials have been implemented trying to shed light on the effect of vascular risk-modifying agents and lifestyle interventions on the prevention and treatment of small vessel disease. Conclusions: Hypertension has a pivotal role in the pathogenesis of CSVD. However, further research is required for a better understanding of the relationship between blood pressure levels and CSVD progression. |
| format | Article |
| id | doaj-art-54cb3e203e4e41f0888f3bcdb1633d2c |
| institution | Kabale University |
| issn | 2079-9721 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diseases |
| spelling | doaj-art-54cb3e203e4e41f0888f3bcdb1633d2c2024-11-26T18:00:07ZengMDPI AGDiseases2079-97212024-10-01121126610.3390/diseases12110266Exploring the Relationship Between Hypertension and Cerebral Microvascular DiseaseVasiliki Katsi0Andreas Mavroudis1Ioannis Liatakis2Manousiadis Konstantinos3Konstantinos Tsioufis4First Cardiology Clinic, School of Medicine, University of Athens, 11527 Athens, GreeceFirst Cardiology Clinic, School of Medicine, University of Athens, 11527 Athens, GreeceFirst Cardiology Clinic, School of Medicine, University of Athens, 11527 Athens, GreeceFirst Cardiology Clinic, School of Medicine, University of Athens, 11527 Athens, GreeceFirst Cardiology Clinic, School of Medicine, University of Athens, 11527 Athens, GreeceBackground/Objectives: Hypertension exerts negative effects on the vasculature representing a key risk factor for cardiovascular disorders, cerebral and Cerebral Small Vessel Disease (CSVD). Methods: An extensive research in the literature was implemented in order to elucidate the role of hypertension in the pathogenesis of CSVD. Results: Hypertension-mediated vascular dysfunction and chronic cerebral hypoperfusion are closely linked to CSVD. CSVD encompasses a wide range of lesions depicted on brain Magnetic Resonance Imaging (MRI) or Computed Tomography (CT) scans. The presenting symptoms and clinical course are highly variable, as a significant proportion of patients remain asymptomatic. Nevertheless, CSVD is associated with an increased risk of stroke, dementia and mobility disorders. Various randomised controlled trials have been implemented trying to shed light on the effect of vascular risk-modifying agents and lifestyle interventions on the prevention and treatment of small vessel disease. Conclusions: Hypertension has a pivotal role in the pathogenesis of CSVD. However, further research is required for a better understanding of the relationship between blood pressure levels and CSVD progression.https://www.mdpi.com/2079-9721/12/11/266hypertensioncerebral small vessel diseasemicrocirculation |
| spellingShingle | Vasiliki Katsi Andreas Mavroudis Ioannis Liatakis Manousiadis Konstantinos Konstantinos Tsioufis Exploring the Relationship Between Hypertension and Cerebral Microvascular Disease Diseases hypertension cerebral small vessel disease microcirculation |
| title | Exploring the Relationship Between Hypertension and Cerebral Microvascular Disease |
| title_full | Exploring the Relationship Between Hypertension and Cerebral Microvascular Disease |
| title_fullStr | Exploring the Relationship Between Hypertension and Cerebral Microvascular Disease |
| title_full_unstemmed | Exploring the Relationship Between Hypertension and Cerebral Microvascular Disease |
| title_short | Exploring the Relationship Between Hypertension and Cerebral Microvascular Disease |
| title_sort | exploring the relationship between hypertension and cerebral microvascular disease |
| topic | hypertension cerebral small vessel disease microcirculation |
| url | https://www.mdpi.com/2079-9721/12/11/266 |
| work_keys_str_mv | AT vasilikikatsi exploringtherelationshipbetweenhypertensionandcerebralmicrovasculardisease AT andreasmavroudis exploringtherelationshipbetweenhypertensionandcerebralmicrovasculardisease AT ioannisliatakis exploringtherelationshipbetweenhypertensionandcerebralmicrovasculardisease AT manousiadiskonstantinos exploringtherelationshipbetweenhypertensionandcerebralmicrovasculardisease AT konstantinostsioufis exploringtherelationshipbetweenhypertensionandcerebralmicrovasculardisease |