Effect of Electroacupuncture at Baihui Acupoint on Magnetic Resonance Spectroscopy and Spatial Learning and Memory Ability in APP/PS1 Transgenic Mice
Objective:To investigate the effects of electroacupuncture (EA) at Baihui (DU20) acupoint on learning and memory ability and<sup>1</sup>H magnetic resonance spectroscopy (<sup>1</sup>H-MRS) in APP/PS1 transgenic mice.Methods:A male APP/PS1 transgenic mice mated with a wild ty...
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Editorial Office of Rehabilitation Medicine
2016-10-01
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| Series: | 康复学报 |
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| Online Access: | http://kfxb.publish.founderss.cn/thesisDetails#10.3724/SP.J.1329.2016.05042 |
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| author | Yingzheng ZHANG Peiyuan ZHUO Ruhui LIN Lidian CHEN |
| author_facet | Yingzheng ZHANG Peiyuan ZHUO Ruhui LIN Lidian CHEN |
| author_sort | Yingzheng ZHANG |
| collection | DOAJ |
| description | Objective:To investigate the effects of electroacupuncture (EA) at Baihui (DU20) acupoint on learning and memory ability and<sup>1</sup>H magnetic resonance spectroscopy (<sup>1</sup>H-MRS) in APP/PS1 transgenic mice.Methods:A male APP/PS1 transgenic mice mated with a wild type female mice and 15 bred APP/PS1 transgenic mice identified by PCR were randomly divided into the model group (<italic>n</italic>=7) and the EA group (<italic>n</italic>=8) according to a random number table, and 8 age-matched littermates were divided into the control group. The EA group received EA at Baihui acupoint for 4 weeks. Morris water maze was used to test spatial learning and memory ability in the fourth week. NAA, Glu of the hippocampus were detected by<sup>1</sup>H-MRS.Results:Compared with the model group, the level of NAA and Glu were significantly increased (<italic>P</italic><0.05). The EA group also ameliorated spatial learning and memory ability (<italic>P</italic><0.05).Conclusion:EA at Baihui acupoint can improve spatial learning and memory ability inAPP/PS1 transgenic mice, the mechanism may be associated with the increasing NAA and Glu of the hippocampus. |
| format | Article |
| id | doaj-art-54be55afda55469cb63aba20c4348e84 |
| institution | Kabale University |
| issn | 2096-0328 |
| language | English |
| publishDate | 2016-10-01 |
| publisher | Editorial Office of Rehabilitation Medicine |
| record_format | Article |
| series | 康复学报 |
| spelling | doaj-art-54be55afda55469cb63aba20c4348e842025-01-14T10:06:08ZengEditorial Office of Rehabilitation Medicine康复学报2096-03282016-10-0126424623096506Effect of Electroacupuncture at Baihui Acupoint on Magnetic Resonance Spectroscopy and Spatial Learning and Memory Ability in APP/PS1 Transgenic MiceYingzheng ZHANGPeiyuan ZHUORuhui LINLidian CHENObjective:To investigate the effects of electroacupuncture (EA) at Baihui (DU20) acupoint on learning and memory ability and<sup>1</sup>H magnetic resonance spectroscopy (<sup>1</sup>H-MRS) in APP/PS1 transgenic mice.Methods:A male APP/PS1 transgenic mice mated with a wild type female mice and 15 bred APP/PS1 transgenic mice identified by PCR were randomly divided into the model group (<italic>n</italic>=7) and the EA group (<italic>n</italic>=8) according to a random number table, and 8 age-matched littermates were divided into the control group. The EA group received EA at Baihui acupoint for 4 weeks. Morris water maze was used to test spatial learning and memory ability in the fourth week. NAA, Glu of the hippocampus were detected by<sup>1</sup>H-MRS.Results:Compared with the model group, the level of NAA and Glu were significantly increased (<italic>P</italic><0.05). The EA group also ameliorated spatial learning and memory ability (<italic>P</italic><0.05).Conclusion:EA at Baihui acupoint can improve spatial learning and memory ability inAPP/PS1 transgenic mice, the mechanism may be associated with the increasing NAA and Glu of the hippocampus.http://kfxb.publish.founderss.cn/thesisDetails#10.3724/SP.J.1329.2016.05042Alzheimer's diseaseelectroacupunctureAPP/PS1magnetic resonance spectroscopyspatial learning and memory ability |
| spellingShingle | Yingzheng ZHANG Peiyuan ZHUO Ruhui LIN Lidian CHEN Effect of Electroacupuncture at Baihui Acupoint on Magnetic Resonance Spectroscopy and Spatial Learning and Memory Ability in APP/PS1 Transgenic Mice 康复学报 Alzheimer's disease electroacupuncture APP/PS1 magnetic resonance spectroscopy spatial learning and memory ability |
| title | Effect of Electroacupuncture at Baihui Acupoint on Magnetic Resonance Spectroscopy and Spatial Learning and Memory Ability in APP/PS1 Transgenic Mice |
| title_full | Effect of Electroacupuncture at Baihui Acupoint on Magnetic Resonance Spectroscopy and Spatial Learning and Memory Ability in APP/PS1 Transgenic Mice |
| title_fullStr | Effect of Electroacupuncture at Baihui Acupoint on Magnetic Resonance Spectroscopy and Spatial Learning and Memory Ability in APP/PS1 Transgenic Mice |
| title_full_unstemmed | Effect of Electroacupuncture at Baihui Acupoint on Magnetic Resonance Spectroscopy and Spatial Learning and Memory Ability in APP/PS1 Transgenic Mice |
| title_short | Effect of Electroacupuncture at Baihui Acupoint on Magnetic Resonance Spectroscopy and Spatial Learning and Memory Ability in APP/PS1 Transgenic Mice |
| title_sort | effect of electroacupuncture at baihui acupoint on magnetic resonance spectroscopy and spatial learning and memory ability in app ps1 transgenic mice |
| topic | Alzheimer's disease electroacupuncture APP/PS1 magnetic resonance spectroscopy spatial learning and memory ability |
| url | http://kfxb.publish.founderss.cn/thesisDetails#10.3724/SP.J.1329.2016.05042 |
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