Unlocking the potential of antimicrobial peptides: Beta-defensins and the future of cancer diagnostics
Oral cancer is a significant public health concern globally, with India reporting a high incidence rate. Genetic factors related to immunity, taste perception, and tooth mineralization are being increasingly studied in the context of dental caries. Beta-defensins, a group of antimicrobial peptides c...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-09-01
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| Series: | Oral Oncology Reports |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2772906024004308 |
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| author | Saranya Velmurugan Gowtham Kumar Subbaraj |
| author_facet | Saranya Velmurugan Gowtham Kumar Subbaraj |
| author_sort | Saranya Velmurugan |
| collection | DOAJ |
| description | Oral cancer is a significant public health concern globally, with India reporting a high incidence rate. Genetic factors related to immunity, taste perception, and tooth mineralization are being increasingly studied in the context of dental caries. Beta-defensins, a group of antimicrobial peptides crucial for innate immunity, have been linked to oral cancer development. Studies have shown dysregulation of beta-defensins, particularly hBD-3, may contribute to oral squamous cell carcinoma progression via modulation of inflammation and immune responses. The Beta-defensin index (BDI), which measures hBD-3 and hBD-2 ratios, shows promise as a non-invasive test for early oral cancer detection. Clinical applications include guiding biopsy decisions and prognostication. Further research on beta defensins’ mechanisms and broader oncological implications is crucial for innovative therapeutic strategies. |
| format | Article |
| id | doaj-art-54b5bc8445704a11bf90d404470f01a9 |
| institution | Kabale University |
| issn | 2772-9060 |
| language | English |
| publishDate | 2024-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Oral Oncology Reports |
| spelling | doaj-art-54b5bc8445704a11bf90d404470f01a92025-01-09T06:16:50ZengElsevierOral Oncology Reports2772-90602024-09-0111100584Unlocking the potential of antimicrobial peptides: Beta-defensins and the future of cancer diagnosticsSaranya Velmurugan0Gowtham Kumar Subbaraj1Faculty of Allied Health Science, Chettinad Hospital and Research Institute, Chettinad Academy of Research and Education, Kelambakkam, 603103, Tamil Nadu, IndiaCorresponding author. Faculty of Allied Health Science, Chettinad Hospital and Research Institute, Chettinad Academy of Research and Education, Kelambakkam, 603103, Tamil Nadu, India.; Faculty of Allied Health Science, Chettinad Hospital and Research Institute, Chettinad Academy of Research and Education, Kelambakkam, 603103, Tamil Nadu, IndiaOral cancer is a significant public health concern globally, with India reporting a high incidence rate. Genetic factors related to immunity, taste perception, and tooth mineralization are being increasingly studied in the context of dental caries. Beta-defensins, a group of antimicrobial peptides crucial for innate immunity, have been linked to oral cancer development. Studies have shown dysregulation of beta-defensins, particularly hBD-3, may contribute to oral squamous cell carcinoma progression via modulation of inflammation and immune responses. The Beta-defensin index (BDI), which measures hBD-3 and hBD-2 ratios, shows promise as a non-invasive test for early oral cancer detection. Clinical applications include guiding biopsy decisions and prognostication. Further research on beta defensins’ mechanisms and broader oncological implications is crucial for innovative therapeutic strategies.http://www.sciencedirect.com/science/article/pii/S2772906024004308 |
| spellingShingle | Saranya Velmurugan Gowtham Kumar Subbaraj Unlocking the potential of antimicrobial peptides: Beta-defensins and the future of cancer diagnostics Oral Oncology Reports |
| title | Unlocking the potential of antimicrobial peptides: Beta-defensins and the future of cancer diagnostics |
| title_full | Unlocking the potential of antimicrobial peptides: Beta-defensins and the future of cancer diagnostics |
| title_fullStr | Unlocking the potential of antimicrobial peptides: Beta-defensins and the future of cancer diagnostics |
| title_full_unstemmed | Unlocking the potential of antimicrobial peptides: Beta-defensins and the future of cancer diagnostics |
| title_short | Unlocking the potential of antimicrobial peptides: Beta-defensins and the future of cancer diagnostics |
| title_sort | unlocking the potential of antimicrobial peptides beta defensins and the future of cancer diagnostics |
| url | http://www.sciencedirect.com/science/article/pii/S2772906024004308 |
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