Long-term dental follow-up in hematological stem cells transplantation children
Objective: The aim of this paper is to update the current published content about the craniofacial long-term development disturbances of childhood hematopoietic stem-cell transplantation (HSCT) and the preparative regimens for the onco-hematological malignancies treatments. Material and Methods: Two...
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| Format: | Article |
| Language: | English |
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Universidade Estadual Paulista
2015-12-01
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| Series: | Brazilian Dental Science |
| Online Access: | https://ojs.ict.unesp.br/index.php/cob/article/view/1196 |
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| author | Luiz Alberto Valente Júnior Paulo Sérgio da Silva Santos Fabio Luiz Coracin Alexandre Viana Frascino Marcelo Fava Vicente Odone Filho |
| author_facet | Luiz Alberto Valente Júnior Paulo Sérgio da Silva Santos Fabio Luiz Coracin Alexandre Viana Frascino Marcelo Fava Vicente Odone Filho |
| author_sort | Luiz Alberto Valente Júnior |
| collection | DOAJ |
| description | Objective: The aim of this paper is to update the current published content about the craniofacial long-term development disturbances of childhood hematopoietic stem-cell transplantation (HSCT) and the preparative regimens for the onco-hematological malignancies treatments. Material and Methods: Two authors independently reviewed the published articles about long-term effects of childhood HSCT that fitted in to predetermined inclusion/exclusion criteria: clear definition of exposure or intervention, standard outcomes measurement and appropriate statistical analysis. Results: Twelve papers matched all the previous established eligibility criteria and were included in this review. The children’s age at HSCT were related to a higher risk of dental development disturbances, such as agenesis, dental hypoplasia, root stunting, crown-root proportion alterations, and microdontia. Craniofacial vertical growth was impaired in the irradiated patients without antero-posterior or latero-lateral impairment. Temporomandibular joint dysfunction was found to be more prevalent in the patients who was diagnosed with graft-versus-host disease. Conclusion: The late effects of craniofacial development disturbances leads to several aesthetic and functional impairment, periodontal bone resorption with consequent impairment of chewing ability, and risk of early tooth loss often associated with life’s quality impairment. Further investigations should be performed to provide accurate information for patients, parents and health care professionals.
Keywords: Dental development. Craniofacial growth. Bone marrow transplantation. Hematopoietic stem-cell transplantation. Chemotherapy. Radiotherapy.
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| format | Article |
| id | doaj-art-549df559e22c4e9da69095eecbf7bfb7 |
| institution | Kabale University |
| issn | 2178-6011 |
| language | English |
| publishDate | 2015-12-01 |
| publisher | Universidade Estadual Paulista |
| record_format | Article |
| series | Brazilian Dental Science |
| spelling | doaj-art-549df559e22c4e9da69095eecbf7bfb72025-08-22T18:13:39ZengUniversidade Estadual PaulistaBrazilian Dental Science2178-60112015-12-0118410.14295/bds.2015.v18i4.1196Long-term dental follow-up in hematological stem cells transplantation childrenLuiz Alberto Valente Júnior0Paulo Sérgio da Silva Santos1Fabio Luiz Coracin2Alexandre Viana Frascino3Marcelo Fava4Vicente Odone Filho5Pediatrics and Special Needs Patients Dental Clinics – Medicine School of São Paulo University – Clinics Hospital School of Medicine – University of São Paulo – São Paulo – SP – Brazil.Department of Stomatology – Bauru School of Dentistry – São Paulo University – São Paulo – SP – Brazil.Oral Pathology and Medicine – University Nove de Julho UNINOVE – Department of Health; Chair of Dental Committee of Brazilian Association of Organ Transplantation – São Paulo – SP – Brazil.Oral and Maxillofacial Surgery Department – School of Dentistry – University of São Paulo – São Paulo – SP – Brazil. Faculdades Metropolitanas Unidas – Department of Oral Surgery – São Paulo – SP – Brazil.Director of Department of Dentistry – Children Institute – Clinics Hospital School of Medicine – University of São Paulo – São Paulo – SP – Brazil. Department of Social and Pediatric Dentistry – School of Dentistry – Institute of Science and Technology – UNESP – Univ Estadual Paulista – São José dos Campos – SP – Brazil.Pediatric Departament and Children Onco-hematological Institute – Medicine School of São Paulo University – Clinics Hospital School of Medicine – University of São Paulo – São Paulo – SP – Brazil.Objective: The aim of this paper is to update the current published content about the craniofacial long-term development disturbances of childhood hematopoietic stem-cell transplantation (HSCT) and the preparative regimens for the onco-hematological malignancies treatments. Material and Methods: Two authors independently reviewed the published articles about long-term effects of childhood HSCT that fitted in to predetermined inclusion/exclusion criteria: clear definition of exposure or intervention, standard outcomes measurement and appropriate statistical analysis. Results: Twelve papers matched all the previous established eligibility criteria and were included in this review. The children’s age at HSCT were related to a higher risk of dental development disturbances, such as agenesis, dental hypoplasia, root stunting, crown-root proportion alterations, and microdontia. Craniofacial vertical growth was impaired in the irradiated patients without antero-posterior or latero-lateral impairment. Temporomandibular joint dysfunction was found to be more prevalent in the patients who was diagnosed with graft-versus-host disease. Conclusion: The late effects of craniofacial development disturbances leads to several aesthetic and functional impairment, periodontal bone resorption with consequent impairment of chewing ability, and risk of early tooth loss often associated with life’s quality impairment. Further investigations should be performed to provide accurate information for patients, parents and health care professionals. Keywords: Dental development. Craniofacial growth. Bone marrow transplantation. Hematopoietic stem-cell transplantation. Chemotherapy. Radiotherapy. https://ojs.ict.unesp.br/index.php/cob/article/view/1196 |
| spellingShingle | Luiz Alberto Valente Júnior Paulo Sérgio da Silva Santos Fabio Luiz Coracin Alexandre Viana Frascino Marcelo Fava Vicente Odone Filho Long-term dental follow-up in hematological stem cells transplantation children Brazilian Dental Science |
| title | Long-term dental follow-up in hematological stem cells transplantation children |
| title_full | Long-term dental follow-up in hematological stem cells transplantation children |
| title_fullStr | Long-term dental follow-up in hematological stem cells transplantation children |
| title_full_unstemmed | Long-term dental follow-up in hematological stem cells transplantation children |
| title_short | Long-term dental follow-up in hematological stem cells transplantation children |
| title_sort | long term dental follow up in hematological stem cells transplantation children |
| url | https://ojs.ict.unesp.br/index.php/cob/article/view/1196 |
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