Comparative analysis of the epidemiological characteristics of adenovirus, rotavirus A, and coinfection in children during 2014–2023 in Guangzhou, China
Abstract Background Infection is the cause of diarrhoea, and rotaviruses and adenoviruses are important pathogens in children. Methods A retrospective study was conducted on 144,067 children with diarrhoea between 2014 and 2023 in China. We used the colloidal gold method to detect intestinal adenovi...
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2024-11-01
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| Online Access: | https://doi.org/10.1186/s12985-024-02537-1 |
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| author | Yuqian Yan Zhiwei Zeng Huixin Gao Shanshui Zeng Siqin Duan Jun Jiang Xiaolan Ai Lanlan Zeng Shuwen Yao Yan Long |
| author_facet | Yuqian Yan Zhiwei Zeng Huixin Gao Shanshui Zeng Siqin Duan Jun Jiang Xiaolan Ai Lanlan Zeng Shuwen Yao Yan Long |
| author_sort | Yuqian Yan |
| collection | DOAJ |
| description | Abstract Background Infection is the cause of diarrhoea, and rotaviruses and adenoviruses are important pathogens in children. Methods A retrospective study was conducted on 144,067 children with diarrhoea between 2014 and 2023 in China. We used the colloidal gold method to detect intestinal adenovirus and rotavirus A antigens in faeces. The epidemiological characteristics of these viruses and the impact of meteorological factors on them were analysed before and after coronavirus disease 2019 (COVID-19) pandemic. Results During this decade, the positive rate of adenovirus infection was 6.41%, while the positive rate of rotavirus A infection was 11.81%, higher than that of adenovirus infection. The positive rate of adenovirus and rotavirus A coinfection was 1.92%. The positive rates of adenovirus, rotavirus A and coinfection showed a fluctuating trend, and suddenly decreased in 2020. There was an apparent decrease of positive rate of rotavirus A, with a decrease of 57.27%, during 2020–2023. Surprisingly, the positive rate of adenovirus infection exceeded that of rotavirus A infection in 2021 and 2023. During the COVID-19 pandemic, the proportion of female patients and children over two years of age infected with adenovirus or rotavirus A increased, while the proportion of cases in winter decreased. In addition, we found that the positive rate of rotavirus A infection was related to average temperature and sunshine, and the positive rate of adenovirus and rotavirus A coinfection was only related to sunshine. However, these correlations disappeared during the COVID-19 pandemic. Conclusions This study revealed the recent prevalence of adenovirus and rotavirus A infections in children with diarrhoea in south-central China and provided a theoretical basis for the prevention and control of viral diarrhoea. |
| format | Article |
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| institution | Kabale University |
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| language | English |
| publishDate | 2024-11-01 |
| publisher | BMC |
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| series | Virology Journal |
| spelling | doaj-art-5476b4aa41744730a432d85daf35a50c2024-11-17T12:09:35ZengBMCVirology Journal1743-422X2024-11-0121111210.1186/s12985-024-02537-1Comparative analysis of the epidemiological characteristics of adenovirus, rotavirus A, and coinfection in children during 2014–2023 in Guangzhou, ChinaYuqian Yan0Zhiwei Zeng1Huixin Gao2Shanshui Zeng3Siqin Duan4Jun Jiang5Xiaolan Ai6Lanlan Zeng7Shuwen Yao8Yan Long9Department of Clinical Laboratory, Guangzhou Women and Children’s Medical Center, Guangzhou Medical UniversityFujian Provincial Key Laboratory of Zoonosis Research, Fujian Center for Disease Control and PreventionDepartment of Clinical Laboratory, Guangzhou Women and Children’s Medical Center, Guangzhou Medical UniversityMicrobiome Medicine Center, Department of Laboratory Medicine, Zhujiang Hospital, Southern Medical UniversityDepartment of Clinical Laboratory, Guangzhou Women and Children’s Medical Center, Guangzhou Medical UniversityDepartment of Clinical Laboratory, Guangzhou Women and Children’s Medical Center, Guangzhou Medical UniversityDepartment of Clinical Laboratory, Guangzhou Women and Children’s Medical Center, Guangzhou Medical UniversityDepartment of Clinical Laboratory, Guangzhou Women and Children’s Medical Center, Guangzhou Medical UniversityDepartment of Clinical Laboratory, Guangzhou Women and Children’s Medical Center, Guangzhou Medical UniversityDepartment of Clinical Laboratory, Guangzhou Women and Children’s Medical Center, Guangzhou Medical UniversityAbstract Background Infection is the cause of diarrhoea, and rotaviruses and adenoviruses are important pathogens in children. Methods A retrospective study was conducted on 144,067 children with diarrhoea between 2014 and 2023 in China. We used the colloidal gold method to detect intestinal adenovirus and rotavirus A antigens in faeces. The epidemiological characteristics of these viruses and the impact of meteorological factors on them were analysed before and after coronavirus disease 2019 (COVID-19) pandemic. Results During this decade, the positive rate of adenovirus infection was 6.41%, while the positive rate of rotavirus A infection was 11.81%, higher than that of adenovirus infection. The positive rate of adenovirus and rotavirus A coinfection was 1.92%. The positive rates of adenovirus, rotavirus A and coinfection showed a fluctuating trend, and suddenly decreased in 2020. There was an apparent decrease of positive rate of rotavirus A, with a decrease of 57.27%, during 2020–2023. Surprisingly, the positive rate of adenovirus infection exceeded that of rotavirus A infection in 2021 and 2023. During the COVID-19 pandemic, the proportion of female patients and children over two years of age infected with adenovirus or rotavirus A increased, while the proportion of cases in winter decreased. In addition, we found that the positive rate of rotavirus A infection was related to average temperature and sunshine, and the positive rate of adenovirus and rotavirus A coinfection was only related to sunshine. However, these correlations disappeared during the COVID-19 pandemic. Conclusions This study revealed the recent prevalence of adenovirus and rotavirus A infections in children with diarrhoea in south-central China and provided a theoretical basis for the prevention and control of viral diarrhoea.https://doi.org/10.1186/s12985-024-02537-1AdenovirusRotavirus ADiarrhoeaMeteorological factorsChildrenSouth-central China |
| spellingShingle | Yuqian Yan Zhiwei Zeng Huixin Gao Shanshui Zeng Siqin Duan Jun Jiang Xiaolan Ai Lanlan Zeng Shuwen Yao Yan Long Comparative analysis of the epidemiological characteristics of adenovirus, rotavirus A, and coinfection in children during 2014–2023 in Guangzhou, China Virology Journal Adenovirus Rotavirus A Diarrhoea Meteorological factors Children South-central China |
| title | Comparative analysis of the epidemiological characteristics of adenovirus, rotavirus A, and coinfection in children during 2014–2023 in Guangzhou, China |
| title_full | Comparative analysis of the epidemiological characteristics of adenovirus, rotavirus A, and coinfection in children during 2014–2023 in Guangzhou, China |
| title_fullStr | Comparative analysis of the epidemiological characteristics of adenovirus, rotavirus A, and coinfection in children during 2014–2023 in Guangzhou, China |
| title_full_unstemmed | Comparative analysis of the epidemiological characteristics of adenovirus, rotavirus A, and coinfection in children during 2014–2023 in Guangzhou, China |
| title_short | Comparative analysis of the epidemiological characteristics of adenovirus, rotavirus A, and coinfection in children during 2014–2023 in Guangzhou, China |
| title_sort | comparative analysis of the epidemiological characteristics of adenovirus rotavirus a and coinfection in children during 2014 2023 in guangzhou china |
| topic | Adenovirus Rotavirus A Diarrhoea Meteorological factors Children South-central China |
| url | https://doi.org/10.1186/s12985-024-02537-1 |
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