Effects of DHEA and DHEAS in Neonatal Hypoxic–Ischemic Brain Injury

Effects of DHEA and DHEAS in Neonatal Hypoxic–Ischemic Brain Injury

Neonatal brain injury remains a significant issue with limited treatment options. This study investigates the potential of the endogenous neurosteroid dehydroepiandrosterone (DHEA) and its sulfate ester (DHEAS) as neuroprotective agents, building on evidence of their mechanisms in adult brain injury...

Full description

Saved in:

Bibliographic Details
Main Authors:	Elena Mayer, Ira Winkler, Eva Huber, Martina Urbanek, Ursula Kiechl-Kohlendorfer, Elke Griesmaier, Anna Posod
Format:	Article
Language:	English
Published:	MDPI AG 2024-12-01
Series:	Antioxidants
Subjects:	dehydroepiandrosterone dehydroepiandrosterone sulfate mouse model hypoxia–ischemia neonatal hypoxic–ischemic brain injury neuroprotection
Online Access:	https://www.mdpi.com/2076-3921/13/12/1542
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Hair Cortisol/DHEA-S Ratios in Healthcare Workers and Their Patients During the COVID-19 Pandemic: A Case Study
by: Isabella Pividori, et al.
Published: (2024-12-01)

A Case–Control Study of the Association of Novel Androgens (11-KT and DHT), Classical Androgens (Testosterone and DHEAS), Hormones (LH, FSH, 17-OHP, Insulin, and SHBG), Insulin Resistance (HOMA-IR), and Dyslipidemia in Polycystic Ovarian Syndrome (PCOS)
by: Nirmal Kumar, et al.
Published: (2025-01-01)

HISTOMORPHOLOGICAL ENHANCEMENT OF THE VAGINAL WALL IN DEHYDROEPIANDROSTERONE-TREATED POST-OVARIECTOMIZED WISTAR RATS
by: Lis Widodo Peni, et al.
Published: (2024-07-01)

Association between glycemia and outcomes of neonates with hypoxic-ischemic encephalopathy: a systematic review and meta-analysis
by: Chen Wang, et al.
Published: (2024-11-01)

Sample size calculations based on day-to-day variability of stress biomarkers in persons with dementia and their family caregivers
by: Azita Emami, et al.
Published: (2024-11-01)

Using of dexmedetomidine in term neonates with hypoxic-ischemic encephalopathy
by: D. Surkov
Published: (2019-11-01)

Effect of a Broiler-Specific Light Spectrum on Growth Performance and Adrenocortical Activity in Chickens: A Pilot Study on a Commercial Farm
by: Livio Galosi, et al.
Published: (2024-12-01)

Features of steroid hormone levels in girls with menstrual cycle disorders and mental health disorders
by: V.O. Dynnik, et al.
Published: (2024-03-01)

Dehydroepiandrosterone and Bone Health: Mechanisms and Insights
by: Nur-Vaizura Mohamad, et al.
Published: (2024-12-01)

Motor Learning Deficits in a Neonatal Mouse Model of Hypoxic-Ischemic Injury
by: Maria Marlicz, et al.
Published: (2024-12-01)

Effects Of Hormonal Supplements In Women with Poor Ovarian Response Undergoing Assisted Reproductive Technology
by: Silan Melis Bozan, et al.
Published: (2021-08-01)

Hypoxic postconditioning modulates neuroprotective glial reactivity in a 3D cortical ischemic-hypoxic injury model
by: Mong Lung Steve Poon, et al.
Published: (2024-11-01)

Advanced Trans-EEGNet Deep Learning Model for Hypoxic-Ischemic Encephalopathy Severity Grading
by: Dong-Her Shih, et al.
Published: (2024-12-01)

A-Three-Year Short-Term Clinical Courses of Newborns with the Diagnosis of Hypoxic Ischemic Encephalopathy in a Tertiary Hospital - Original Article
by: Serkan Kemer, et al.
Published: (2010-12-01)

Antioxidant Therapy in Neonatal Hypoxic Ischemic Encephalopathy: Adjuvant or Future Alternative to Therapeutic Hypothermia?
by: Veronica Notarbartolo, et al.
Published: (2024-11-01)

Causal relationship of genetically predicted particulate matter 2.5 level with Alzheimer’s disease and the mediating effect of dehydroepiandrosterone sulphate
by: Zehan Huang, et al.
Published: (2024-12-01)

Correlation Analysis of Hypothalamic-Pituitary-Adrenal Axis Hormone Levels in Hair before Stroke Onset and Mood Disorders after Stroke
by: WANG Tiantian, et al.
Published: (2024-06-01)

Hydrogen gas inhalation ameliorates glomerular enlargement after hypoxic-ischemic insult in asphyxiated piglet model
by: Takuma Iwaki, et al.
Published: (2025-01-01)

Hypoxic-ischemic brain injury in pig after cardiac arrest – A new histopathological scoring system for non-specialists
by: Miriam Renz, et al.
Published: (2024-12-01)

Molecular mechanism underlying cardioprotective effect of dehydroepiandrosterone on endoplasmic reticulum stress induced apoptosis in human vascular smooth muscle cells and human umbilical vein endothelial cells
by: Ye Zhu, et al.
Published: (2025-01-01)

Age and estrogen-associated reductions in hypoxic ventilatory response and chemosensitivity in female rats
by: Jessica M. L. Grittner, et al.
Published: (2025-01-01)

Temporal dynamics of neonatal hypoxic–ischemic encephalopathy injuries on magnetic resonance imaging
by: Holly Flyger, et al.
Published: (2025-11-01)

Effect of ultrasound combined with microbubbles therapy on tumor hypoxic microenvironment
by: Yuyi Feng, et al.
Published: (2025-01-01)

Activation of the Nrf2/Keap1 signaling pathway mediates the neuroprotective effect of Perillyl alcohol against cerebral hypoxic-ischemic damage in neonatal rats
by: Yu Fang, et al.
Published: (2024-12-01)

hUC-MSC extracellular vesicles protect against hypoxic-ischemic brain injury by promoting NLRP3 ubiquitination
by: Shanshan Xiao, et al.
Published: (2024-12-01)

The influence of exogenous recombinant HSP 70 on the alteration of membrane stiffness in hippocampal neurons following the modeling of neonatal hypoxic-ischemic injury in mice Authors
by: Vladimir M. Pokrovsky, et al.
Published: (2024-12-01)

Neonatal hypoxia-ischemia alters the events governing the hippocampal critical period of postnatal synaptic plasticity leading to deficits in working memory in mice
by: Pritika Parmar, et al.
Published: (2024-11-01)

Near-infrared spectroscopy: bilateral brain monitoring in termed newborns with hypoxic-ischemic lesions.
by: T. К. Mavropulo, et al.
Published: (2020-04-01)

The Importance of Including Maternal Immune Activation in Animal Models of Hypoxic–Ischemic Encephalopathy
by: Bailey Collins, et al.
Published: (2024-11-01)

Pharmacokinetics of 7,8-dihydroxyflavone in neonatal mice with hypoxia-ischemia related brain injury
by: Sin Yin Lim, et al.
Published: (2025-01-01)

A potential innovative surrogate marker for hypoxic injury: Shehata marker of angiogenesis
by: Shehata A. Mohamed
Published: (2025-01-01)

Monoamines, BDNF, Dehydroepiandrosterone, DHEA-Sulfate, and Childhood Depression—An Animal Model Study
by: O. Malkesman, et al.
Published: (2009-01-01)

Antenatal Magnesium Sulfate Benefits Female Preterm Infants but Results in Poor Male Outcomes
by: Ruth M. McLeod, et al.
Published: (2024-02-01)

Biomimetic astrocyte cell membrane-fused nanovesicles for protecting neurovascular units in hypoxic ischemic encephalopathy
by: Zihao Liu, et al.
Published: (2024-12-01)

Role of pentoxifylline in neonatal hypoxic ischaemic encephalopathy: a systematic review of animal studies
by: Florence Wong, et al.
Published: (2024-11-01)

Key genes and regulatory networks of hypoxic preconditioning on osteoblasts
by: Dong Wang, et al.
Published: (2023-12-01)

RETRACTED: Role of IL-1β, Prolactin and DHEA in men Patients Infected with Toxoplasmosis
by: Ali faieq Zahraa, et al.
Published: (2024-01-01)

Neuroinflammation mediates the progression of neonate hypoxia-ischemia brain damage to Alzheimer’s disease: a bioinformatics and experimental study
by: Shengjie Zhang, et al.
Published: (2025-01-01)

Response to ‘Commentary on the published position statement regarding the pathogenesis of fetal basal ganglia- thalamic hypoxic-ischaemic injury’ (Anthony et al.)
by: I Bhorat, et al.
Published: (2023-12-01)

Costs of Care for Neonates with Hypoxic-Ischemic Encephalopathy Treated with Therapeutic Hypothermia and Validation of the Canadian Neonatal Network Costing Algorithm
by: Elias Jabbour, MSc, et al.
Published: (2024-12-01)