Elevated vesicular Zn2+ in dorsal root ganglion neurons expressing the transporter TMEM163 causes age-associated itchy skin in mice.

Elevated vesicular Zn2+ in dorsal root ganglion neurons expressing the transporter TMEM163 causes age-associated itchy skin in mice.

The prevalent itching condition associated with aging, historically referred to as senile pruritus, diminishes quality of life. Despite its impact, effective treatments remain elusive, largely due to an incomplete understanding of its pathological cause. In this study, we reveal a subset of dorsal r...

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Main Authors: Fang Tong, Shuai Liu, Chen Zhang, Xicheng Gu, Huan Yang, Bin Zhou, Yun-Yun Wang, Jianwei Chen, Qianhui Qu, Ye Gong, Haili Pan, Chen Liang, Changlin Li, Xin Zhang, Qingjian Han
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2024-11-01
Series:PLoS Biology
Online Access:https://doi.org/10.1371/journal.pbio.3002888
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