Influence of Cytokine Genetic Polymorphisms in Helicobacter pylori-Associated Gastric Inflammation According to Sex in South Korea
Background/Aims: The relationship between genetic polymorphisms and gastric inflammation remains unclear. This study aimed to evaluate the impact of genetic polymorphisms on Helicobacter pylori (HP)-associated gastritis according to sex. Methods: Two hundred thirty-two male and 404 female subjects w...
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Gastroenterology Council for Gut and Liver
2024-11-01
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| Series: | Gut and Liver |
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| Online Access: | http://gutnliver.org/journal/view.html?doi=10.5009/gnl230359 |
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| author | Hee Jin Kim Nayoung Kim Jae Young Jang Sihyun Kim Jongchan Lee Hyeon Jeong Oh |
| author_facet | Hee Jin Kim Nayoung Kim Jae Young Jang Sihyun Kim Jongchan Lee Hyeon Jeong Oh |
| author_sort | Hee Jin Kim |
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| description | Background/Aims: The relationship between genetic polymorphisms and gastric inflammation remains unclear. This study aimed to evaluate the impact of genetic polymorphisms on Helicobacter pylori (HP)-associated gastritis according to sex. Methods: Two hundred thirty-two male and 404 female subjects with current HP infection were prospectively enrolled. The genotyping of IL-1B-511 C/T, IL-1RN variable number of tandem repeats, IL-6-572 G/C, IL-8-251 A/T, IL-8-781 C/T, IL-10-1082 G/A, IL-10-592 C/A, TNF-A-308 G/A, and transforming growth factor (TGF)-B-509 C/T, was determined by polymerase chain reaction-restriction fragment length polymorphism. The degree of monocyte or neutrophil infiltration, atrophic gastritis, and intestinal metaplasia was evaluated using the updated Sydney system. Results: Among the male subjects, moderate/severe atrophic gastritis of the corpus was higher in IL-1B-511 CC carriers than in CT and TT carriers independent of age, alcohol consumption, and HP virulence factors (26.9% vs 10.4%; adjusted hazard ratio [HR], 4.377; 95% confidence interval, 1.387 to 13.814). In females, IL-8-251 AA carriers were independently and significantly associated with moderate/severe atrophic gastritis of the corpus compared with that in AT and TT carriers (21.4% vs 6.0%, adjusted HR=3.799). In males, the IL-8-251 TT genotype was associated with moderate/severe intestinal metaplasia of the corpus compared with the AT and AA genotypes (13.4% vs 5.6%, adjusted HR=3.128), while the IL-10-592 CA and CC genotypes were associated with moderate/severe monocyte infiltration of the antrum compared with AA genotype (83.6% vs 71.8%, adjusted HR=2.227). Conclusions: Genetic polymorphisms in cytokines play different roles in HP-associated gastritis according to sex. |
| format | Article |
| id | doaj-art-54516a595d1b44ddaf7fb9e4808b71c2 |
| institution | Kabale University |
| issn | 1976-2283 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Gastroenterology Council for Gut and Liver |
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| series | Gut and Liver |
| spelling | doaj-art-54516a595d1b44ddaf7fb9e4808b71c22024-11-15T06:27:53ZengGastroenterology Council for Gut and LiverGut and Liver1976-22832024-11-011861002101310.5009/gnl230359gnl230359Influence of Cytokine Genetic Polymorphisms in Helicobacter pylori-Associated Gastric Inflammation According to Sex in South KoreaHee Jin Kim0Nayoung Kim1Jae Young Jang2Sihyun Kim3Jongchan Lee4Hyeon Jeong Oh5Department of Internal Medicine, Gyeongsang National University Changwon Hospital, Gyeongsang National University College of Medicine, Changwon, KoreaDepartment of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, KoreaDepartment of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, KoreaDepartment of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, KoreaDepartment of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, KoreaDepartment of Pathology, Seoul National University Bundang Hospital, Seongnam, KoreaBackground/Aims: The relationship between genetic polymorphisms and gastric inflammation remains unclear. This study aimed to evaluate the impact of genetic polymorphisms on Helicobacter pylori (HP)-associated gastritis according to sex. Methods: Two hundred thirty-two male and 404 female subjects with current HP infection were prospectively enrolled. The genotyping of IL-1B-511 C/T, IL-1RN variable number of tandem repeats, IL-6-572 G/C, IL-8-251 A/T, IL-8-781 C/T, IL-10-1082 G/A, IL-10-592 C/A, TNF-A-308 G/A, and transforming growth factor (TGF)-B-509 C/T, was determined by polymerase chain reaction-restriction fragment length polymorphism. The degree of monocyte or neutrophil infiltration, atrophic gastritis, and intestinal metaplasia was evaluated using the updated Sydney system. Results: Among the male subjects, moderate/severe atrophic gastritis of the corpus was higher in IL-1B-511 CC carriers than in CT and TT carriers independent of age, alcohol consumption, and HP virulence factors (26.9% vs 10.4%; adjusted hazard ratio [HR], 4.377; 95% confidence interval, 1.387 to 13.814). In females, IL-8-251 AA carriers were independently and significantly associated with moderate/severe atrophic gastritis of the corpus compared with that in AT and TT carriers (21.4% vs 6.0%, adjusted HR=3.799). In males, the IL-8-251 TT genotype was associated with moderate/severe intestinal metaplasia of the corpus compared with the AT and AA genotypes (13.4% vs 5.6%, adjusted HR=3.128), while the IL-10-592 CA and CC genotypes were associated with moderate/severe monocyte infiltration of the antrum compared with AA genotype (83.6% vs 71.8%, adjusted HR=2.227). Conclusions: Genetic polymorphisms in cytokines play different roles in HP-associated gastritis according to sex.http://gutnliver.org/journal/view.html?doi=10.5009/gnl230359helicobacter pyloripolymorphismgeneticsexgastritisatrophic gastritis |
| spellingShingle | Hee Jin Kim Nayoung Kim Jae Young Jang Sihyun Kim Jongchan Lee Hyeon Jeong Oh Influence of Cytokine Genetic Polymorphisms in Helicobacter pylori-Associated Gastric Inflammation According to Sex in South Korea Gut and Liver helicobacter pylori polymorphism genetic sex gastritis atrophic gastritis |
| title | Influence of Cytokine Genetic Polymorphisms in Helicobacter pylori-Associated Gastric Inflammation According to Sex in South Korea |
| title_full | Influence of Cytokine Genetic Polymorphisms in Helicobacter pylori-Associated Gastric Inflammation According to Sex in South Korea |
| title_fullStr | Influence of Cytokine Genetic Polymorphisms in Helicobacter pylori-Associated Gastric Inflammation According to Sex in South Korea |
| title_full_unstemmed | Influence of Cytokine Genetic Polymorphisms in Helicobacter pylori-Associated Gastric Inflammation According to Sex in South Korea |
| title_short | Influence of Cytokine Genetic Polymorphisms in Helicobacter pylori-Associated Gastric Inflammation According to Sex in South Korea |
| title_sort | influence of cytokine genetic polymorphisms in helicobacter pylori associated gastric inflammation according to sex in south korea |
| topic | helicobacter pylori polymorphism genetic sex gastritis atrophic gastritis |
| url | http://gutnliver.org/journal/view.html?doi=10.5009/gnl230359 |
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