Plasma-exchange therapy in acute immune-mediated neuropathy: Effects on muscle strength and functional outcomes
Background and objectives. This study explores the impact of plasma exchange therapy (TPE) on muscle strength and functional outcomes in patients with acute immune-mediated neuropathy. Materials and methods. We retrospectively analyzed clinical data from patients diagnosed with acute immune-mediated...
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| Format: | Article |
| Language: | English |
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Amaltea Medical Publishing House
2024-06-01
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| Series: | Romanian Journal of Neurology |
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| Online Access: | https://rjn.com.ro/articles/2024.2/RJN_2024_2_Art-12.pdf |
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| author | Noor Ahmed Khosa Syed Muhammad Essa Muhammad Samsoor Zarak Ahsan Ul Haq Zarkoon Ismail A. Ibrahim Tamor Mumtaz |
| author_facet | Noor Ahmed Khosa Syed Muhammad Essa Muhammad Samsoor Zarak Ahsan Ul Haq Zarkoon Ismail A. Ibrahim Tamor Mumtaz |
| author_sort | Noor Ahmed Khosa |
| collection | DOAJ |
| description | Background and objectives. This study explores the impact of plasma exchange therapy (TPE) on muscle strength and functional outcomes in patients with acute immune-mediated neuropathy. Materials and methods. We retrospectively analyzed clinical data from patients diagnosed with acute immune-mediated neuropathy at the Department of Neurology, Bolan University of Medical Sciences, Baluchistan, from January 2016 to December 2021. Results. The study, comprising 141 patients with various neurological disorders, underscores the efficacy of plasma exchange therapy in improving muscle strength and functional outcomes, particularly in Guillain-Barré Syndrome (GBS). Notably, after four weeks of treatment, a significant proportion of patients demonstrated improved mobility, with 51.8% able to walk without assistance. However, despite the positive response to therapy, a small percentage (2.8%) experienced unfavorable outcomes marked by expiration. Additionally, the study identifies significant associations between treatment outcomes and patient characteristics, such as the number of plasma exchange cycles and diagnosis (p <0.05), emphasizing
the importance of personalized treatment approaches in managing neurological disorders. Conclusions. Our findings underscore the effectiveness of plasma exchange in enhancing muscle strength and functional outcomes in acute immune-mediated neuropathy, particularly GBS. |
| format | Article |
| id | doaj-art-5445d0913a054244b3b0250fabb7f7df |
| institution | Kabale University |
| issn | 1843-8148 2069-6094 |
| language | English |
| publishDate | 2024-06-01 |
| publisher | Amaltea Medical Publishing House |
| record_format | Article |
| series | Romanian Journal of Neurology |
| spelling | doaj-art-5445d0913a054244b3b0250fabb7f7df2024-12-10T13:44:22ZengAmaltea Medical Publishing HouseRomanian Journal of Neurology1843-81482069-60942024-06-0123216016510.37897/RJN.2024.2.12Plasma-exchange therapy in acute immune-mediated neuropathy: Effects on muscle strength and functional outcomesNoor Ahmed Khosa0Syed Muhammad Essa1Muhammad Samsoor Zarak2Ahsan Ul Haq Zarkoon3Ismail A. Ibrahim4Tamor Mumtaz5Department of Neurology, Bolan Medical Complex Hospital, Quetta, PakistanDepartment of Neurology, Bolan Medical Complex Hospital, Quetta, PakistanHoward University Hospital, Washington DC, USADepartment of Neurology, Bolan Medical Complex Hospital, Quetta, PakistanFaculty of Health Sciences, Fenerbahçe University, Istanbul, TurkeyDepartment of Neurology, Bolan Medical Complex Hospital, Quetta, PakistanBackground and objectives. This study explores the impact of plasma exchange therapy (TPE) on muscle strength and functional outcomes in patients with acute immune-mediated neuropathy. Materials and methods. We retrospectively analyzed clinical data from patients diagnosed with acute immune-mediated neuropathy at the Department of Neurology, Bolan University of Medical Sciences, Baluchistan, from January 2016 to December 2021. Results. The study, comprising 141 patients with various neurological disorders, underscores the efficacy of plasma exchange therapy in improving muscle strength and functional outcomes, particularly in Guillain-Barré Syndrome (GBS). Notably, after four weeks of treatment, a significant proportion of patients demonstrated improved mobility, with 51.8% able to walk without assistance. However, despite the positive response to therapy, a small percentage (2.8%) experienced unfavorable outcomes marked by expiration. Additionally, the study identifies significant associations between treatment outcomes and patient characteristics, such as the number of plasma exchange cycles and diagnosis (p <0.05), emphasizing the importance of personalized treatment approaches in managing neurological disorders. Conclusions. Our findings underscore the effectiveness of plasma exchange in enhancing muscle strength and functional outcomes in acute immune-mediated neuropathy, particularly GBS.https://rjn.com.ro/articles/2024.2/RJN_2024_2_Art-12.pdfplasma-exchange therapyneurological disordersguillain-barré syndromemuscle strengthfunctional outcomes |
| spellingShingle | Noor Ahmed Khosa Syed Muhammad Essa Muhammad Samsoor Zarak Ahsan Ul Haq Zarkoon Ismail A. Ibrahim Tamor Mumtaz Plasma-exchange therapy in acute immune-mediated neuropathy: Effects on muscle strength and functional outcomes Romanian Journal of Neurology plasma-exchange therapy neurological disorders guillain-barré syndrome muscle strength functional outcomes |
| title | Plasma-exchange therapy in acute immune-mediated neuropathy: Effects on muscle strength and functional outcomes |
| title_full | Plasma-exchange therapy in acute immune-mediated neuropathy: Effects on muscle strength and functional outcomes |
| title_fullStr | Plasma-exchange therapy in acute immune-mediated neuropathy: Effects on muscle strength and functional outcomes |
| title_full_unstemmed | Plasma-exchange therapy in acute immune-mediated neuropathy: Effects on muscle strength and functional outcomes |
| title_short | Plasma-exchange therapy in acute immune-mediated neuropathy: Effects on muscle strength and functional outcomes |
| title_sort | plasma exchange therapy in acute immune mediated neuropathy effects on muscle strength and functional outcomes |
| topic | plasma-exchange therapy neurological disorders guillain-barré syndrome muscle strength functional outcomes |
| url | https://rjn.com.ro/articles/2024.2/RJN_2024_2_Art-12.pdf |
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