Maternal seafood intake, dietary contaminant exposure, and risk of juvenile idiopathic arthritis: exploring gene-environment interactions
ObjectivesJuvenile idiopathic arthritis (JIA) originates from a complex interplay between genetic and environmental factors. We investigated the association between seafood intake and dietary contaminant exposure during pregnancy and JIA risk, to identify sex differences and gene-environment interac...
Saved in:
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-01-01
|
| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1523990/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1841540110389084160 |
|---|---|
| author | Vilde Øverlien Dåstøl Vilde Øverlien Dåstøl Kristine Løkås Haftorn Hamid Khoshfekr Rudsari Piotr Pawel Jaholkowski Piotr Pawel Jaholkowski Ketil Størdal Ketil Størdal Siri Eldevik Håberg Siri Eldevik Håberg Clarice R. Weinberg Lisa G. Rider Ole A. Andreassen Ole A. Andreassen Ole A. Andreassen Anne Lise Brantsæter Ida Henriette Caspersen Ida Henriette Caspersen Helga Sanner Helga Sanner |
| author_facet | Vilde Øverlien Dåstøl Vilde Øverlien Dåstøl Kristine Løkås Haftorn Hamid Khoshfekr Rudsari Piotr Pawel Jaholkowski Piotr Pawel Jaholkowski Ketil Størdal Ketil Størdal Siri Eldevik Håberg Siri Eldevik Håberg Clarice R. Weinberg Lisa G. Rider Ole A. Andreassen Ole A. Andreassen Ole A. Andreassen Anne Lise Brantsæter Ida Henriette Caspersen Ida Henriette Caspersen Helga Sanner Helga Sanner |
| author_sort | Vilde Øverlien Dåstøl |
| collection | DOAJ |
| description | ObjectivesJuvenile idiopathic arthritis (JIA) originates from a complex interplay between genetic and environmental factors. We investigated the association between seafood intake and dietary contaminant exposure during pregnancy and JIA risk, to identify sex differences and gene-environment interactions.MethodsWe used the Norwegian Mother, Father, and Child Cohort Study (MoBa), a population-based prospective pregnancy cohort (1999–2008). JIA patients were identified through the Norwegian Patient Registry, with remaining mother-child pairs serving as controls. We assessed maternal seafood intake and dietary contaminants typically found in seafood using a food frequency questionnaire completed during pregnancy, mainly comparing high (≥90th percentile, P90) vs low (<P90) intake. Multivariable logistic regression calculated adjusted odds ratios (aOR), including sex-stratification analyses. A polygenic risk score (PRS) for JIA was used in a subsample to assess gene-environment interactions.ResultsWe identified 217 JIA patients and 71,884 controls. High vs low maternal intake of lean/semi-oily fish was associated with JIA (aOR 1.51, 95% CI 1.02-2.22), especially among boys (aOR 2.13, 95% CI 1.21-3.75). A significant gene-environment interaction was observed between total fish intake and PRS, with high fish intake associated with JIA primarily in those with low PRS (p<0.03). We found no associations between high vs low exposure to other types of seafood or environmental contaminants and JIA.ConclusionsWe found a modestly increased risk of JIA associated with high intake of lean/semi-oily fish during pregnancy, not explained by estimated exposure to dietary contaminants. Our data suggest a more pronounced association in children with a lower genetic predisposition for JIA. |
| format | Article |
| id | doaj-art-543cf762a37b43faac3f81c2f37b5924 |
| institution | Kabale University |
| issn | 1664-3224 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-543cf762a37b43faac3f81c2f37b59242025-01-14T05:10:34ZengFrontiers Media S.A.Frontiers in Immunology1664-32242025-01-011510.3389/fimmu.2024.15239901523990Maternal seafood intake, dietary contaminant exposure, and risk of juvenile idiopathic arthritis: exploring gene-environment interactionsVilde Øverlien Dåstøl0Vilde Øverlien Dåstøl1Kristine Løkås Haftorn2Hamid Khoshfekr Rudsari3Piotr Pawel Jaholkowski4Piotr Pawel Jaholkowski5Ketil Størdal6Ketil Størdal7Siri Eldevik Håberg8Siri Eldevik Håberg9Clarice R. Weinberg10Lisa G. Rider11Ole A. Andreassen12Ole A. Andreassen13Ole A. Andreassen14Anne Lise Brantsæter15Ida Henriette Caspersen16Ida Henriette Caspersen17Helga Sanner18Helga Sanner19Department of Rheumatology, Oslo University Hospital, Oslo, NorwayInstitute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, NorwayDepartment of Rheumatology, Oslo University Hospital, Oslo, NorwayDepartment of Rheumatology, Oslo University Hospital, Oslo, NorwayCenter for Precision Psychiatry, Division of Mental Health and Addiction, Oslo University Hospital, and Institute of Clinical Medicine, University of Oslo, Oslo, NorwayKG Jebsen Centre for Neurodevelopmental Disorders, University of Oslo and Oslo University Hospital, Oslo, NorwayDepartment of Pediatric Research, Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, NorwayDepartment of Pediatric and Adolescent Medicine, Oslo University Hospital, Oslo, NorwayCentre for Fertility and Health, Norwegian Institute of Public Health, Oslo, NorwayDepartment of Global Public Health and Primary Care, University of Bergen, Bergen, NorwayBiostatistics and Computational Biology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC, United States0Environmental Autoimmunity Group, Clinical Research Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Bethesda, MD, United StatesInstitute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, NorwayKG Jebsen Centre for Neurodevelopmental Disorders, University of Oslo and Oslo University Hospital, Oslo, Norway1Center for Precision Psychiatry, Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway2Department of Food Safety and Centre for Sustainable Diets, Norwegian Institute of Public Health, Oslo, NorwayDepartment of Rheumatology, Oslo University Hospital, Oslo, NorwayCentre for Fertility and Health, Norwegian Institute of Public Health, Oslo, NorwayDepartment of Rheumatology, Oslo University Hospital, Oslo, Norway3Oslo New University College, Oslo, NorwayObjectivesJuvenile idiopathic arthritis (JIA) originates from a complex interplay between genetic and environmental factors. We investigated the association between seafood intake and dietary contaminant exposure during pregnancy and JIA risk, to identify sex differences and gene-environment interactions.MethodsWe used the Norwegian Mother, Father, and Child Cohort Study (MoBa), a population-based prospective pregnancy cohort (1999–2008). JIA patients were identified through the Norwegian Patient Registry, with remaining mother-child pairs serving as controls. We assessed maternal seafood intake and dietary contaminants typically found in seafood using a food frequency questionnaire completed during pregnancy, mainly comparing high (≥90th percentile, P90) vs low (<P90) intake. Multivariable logistic regression calculated adjusted odds ratios (aOR), including sex-stratification analyses. A polygenic risk score (PRS) for JIA was used in a subsample to assess gene-environment interactions.ResultsWe identified 217 JIA patients and 71,884 controls. High vs low maternal intake of lean/semi-oily fish was associated with JIA (aOR 1.51, 95% CI 1.02-2.22), especially among boys (aOR 2.13, 95% CI 1.21-3.75). A significant gene-environment interaction was observed between total fish intake and PRS, with high fish intake associated with JIA primarily in those with low PRS (p<0.03). We found no associations between high vs low exposure to other types of seafood or environmental contaminants and JIA.ConclusionsWe found a modestly increased risk of JIA associated with high intake of lean/semi-oily fish during pregnancy, not explained by estimated exposure to dietary contaminants. Our data suggest a more pronounced association in children with a lower genetic predisposition for JIA.https://www.frontiersin.org/articles/10.3389/fimmu.2024.1523990/fulljuvenile idiopathic arthritis (JIA)MoBafishcontaminantsheavy metalspolygenic risk score |
| spellingShingle | Vilde Øverlien Dåstøl Vilde Øverlien Dåstøl Kristine Løkås Haftorn Hamid Khoshfekr Rudsari Piotr Pawel Jaholkowski Piotr Pawel Jaholkowski Ketil Størdal Ketil Størdal Siri Eldevik Håberg Siri Eldevik Håberg Clarice R. Weinberg Lisa G. Rider Ole A. Andreassen Ole A. Andreassen Ole A. Andreassen Anne Lise Brantsæter Ida Henriette Caspersen Ida Henriette Caspersen Helga Sanner Helga Sanner Maternal seafood intake, dietary contaminant exposure, and risk of juvenile idiopathic arthritis: exploring gene-environment interactions Frontiers in Immunology juvenile idiopathic arthritis (JIA) MoBa fish contaminants heavy metals polygenic risk score |
| title | Maternal seafood intake, dietary contaminant exposure, and risk of juvenile idiopathic arthritis: exploring gene-environment interactions |
| title_full | Maternal seafood intake, dietary contaminant exposure, and risk of juvenile idiopathic arthritis: exploring gene-environment interactions |
| title_fullStr | Maternal seafood intake, dietary contaminant exposure, and risk of juvenile idiopathic arthritis: exploring gene-environment interactions |
| title_full_unstemmed | Maternal seafood intake, dietary contaminant exposure, and risk of juvenile idiopathic arthritis: exploring gene-environment interactions |
| title_short | Maternal seafood intake, dietary contaminant exposure, and risk of juvenile idiopathic arthritis: exploring gene-environment interactions |
| title_sort | maternal seafood intake dietary contaminant exposure and risk of juvenile idiopathic arthritis exploring gene environment interactions |
| topic | juvenile idiopathic arthritis (JIA) MoBa fish contaminants heavy metals polygenic risk score |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1523990/full |
| work_keys_str_mv | AT vildeøverliendastøl maternalseafoodintakedietarycontaminantexposureandriskofjuvenileidiopathicarthritisexploringgeneenvironmentinteractions AT vildeøverliendastøl maternalseafoodintakedietarycontaminantexposureandriskofjuvenileidiopathicarthritisexploringgeneenvironmentinteractions AT kristineløkashaftorn maternalseafoodintakedietarycontaminantexposureandriskofjuvenileidiopathicarthritisexploringgeneenvironmentinteractions AT hamidkhoshfekrrudsari maternalseafoodintakedietarycontaminantexposureandriskofjuvenileidiopathicarthritisexploringgeneenvironmentinteractions AT piotrpaweljaholkowski maternalseafoodintakedietarycontaminantexposureandriskofjuvenileidiopathicarthritisexploringgeneenvironmentinteractions AT piotrpaweljaholkowski maternalseafoodintakedietarycontaminantexposureandriskofjuvenileidiopathicarthritisexploringgeneenvironmentinteractions AT ketilstørdal maternalseafoodintakedietarycontaminantexposureandriskofjuvenileidiopathicarthritisexploringgeneenvironmentinteractions AT ketilstørdal maternalseafoodintakedietarycontaminantexposureandriskofjuvenileidiopathicarthritisexploringgeneenvironmentinteractions AT sirieldevikhaberg maternalseafoodintakedietarycontaminantexposureandriskofjuvenileidiopathicarthritisexploringgeneenvironmentinteractions AT sirieldevikhaberg maternalseafoodintakedietarycontaminantexposureandriskofjuvenileidiopathicarthritisexploringgeneenvironmentinteractions AT claricerweinberg maternalseafoodintakedietarycontaminantexposureandriskofjuvenileidiopathicarthritisexploringgeneenvironmentinteractions AT lisagrider maternalseafoodintakedietarycontaminantexposureandriskofjuvenileidiopathicarthritisexploringgeneenvironmentinteractions AT oleaandreassen maternalseafoodintakedietarycontaminantexposureandriskofjuvenileidiopathicarthritisexploringgeneenvironmentinteractions AT oleaandreassen maternalseafoodintakedietarycontaminantexposureandriskofjuvenileidiopathicarthritisexploringgeneenvironmentinteractions AT oleaandreassen maternalseafoodintakedietarycontaminantexposureandriskofjuvenileidiopathicarthritisexploringgeneenvironmentinteractions AT annelisebrantsæter maternalseafoodintakedietarycontaminantexposureandriskofjuvenileidiopathicarthritisexploringgeneenvironmentinteractions AT idahenriettecaspersen maternalseafoodintakedietarycontaminantexposureandriskofjuvenileidiopathicarthritisexploringgeneenvironmentinteractions AT idahenriettecaspersen maternalseafoodintakedietarycontaminantexposureandriskofjuvenileidiopathicarthritisexploringgeneenvironmentinteractions AT helgasanner maternalseafoodintakedietarycontaminantexposureandriskofjuvenileidiopathicarthritisexploringgeneenvironmentinteractions AT helgasanner maternalseafoodintakedietarycontaminantexposureandriskofjuvenileidiopathicarthritisexploringgeneenvironmentinteractions |