Platelets in preeclampsia: an observational study of indices associated with aspirin nonresponsiveness, activation and transcriptional landscape

Platelets in preeclampsia: an observational study of indices associated with aspirin nonresponsiveness, activation and transcriptional landscape

Abstract Background Platelets play critical roles in the pathogenesis of preeclampsia, including thrombosis, endothelial dysfunction and inflammation. However, preeclampsia-associated changes in platelet gene expression and activation at the maternal–foetal interface remain unknown. Moreover, aspiri...

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Main Authors: Gashaw Garedew Woldeamanuel, Kenean Getaneh Tlaye, Xueqin Wang, Long Nguyen-Hoang, Qiongjie Zhou, Yinan Wang, Bo Wah Leung, Yao Wang, Liona C. Poon, Chi Chiu Wang
Format: Article
Language:English
Published: BMC 2025-06-01
Series:BMC Medicine
Subjects:
Platelets
Preeclampsia
Aspirin
Transcriptome
Online Access:https://doi.org/10.1186/s12916-025-04132-9
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