Molecular interaction of human papilloma virus (HPV) with microRANs: insights into the development of cervical cancer and treatment approaches
Abstract Cervical cancer is one of the leading causes of cancer-related death among women worldwide, and high-risk human papillomavirus (HR-HPV) plays a crucial role in its development. HPV’s oncogenic processes include the viral oncoproteins E6 and E7, which interfere with essential biological proc...
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| Format: | Article |
| Language: | English |
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BMC
2025-07-01
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| Series: | Infectious Agents and Cancer |
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| Online Access: | https://doi.org/10.1186/s13027-025-00677-9 |
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| author | Seyedeh Mahdieh Khoshnazar Navvabeh Salarizadeh Maryam Mohammad-Sadeghipour Amirhossein Shahpar Morteza Izadi Mohammad Javad Behzadnia Mahdi Farhadi Khoozani Mina Alimohammadi Najma Farahani Kiavash Hushmandi |
| author_facet | Seyedeh Mahdieh Khoshnazar Navvabeh Salarizadeh Maryam Mohammad-Sadeghipour Amirhossein Shahpar Morteza Izadi Mohammad Javad Behzadnia Mahdi Farhadi Khoozani Mina Alimohammadi Najma Farahani Kiavash Hushmandi |
| author_sort | Seyedeh Mahdieh Khoshnazar |
| collection | DOAJ |
| description | Abstract Cervical cancer is one of the leading causes of cancer-related death among women worldwide, and high-risk human papillomavirus (HR-HPV) plays a crucial role in its development. HPV’s oncogenic processes include the viral oncoproteins E6 and E7, which interfere with essential biological processes, causing DNA instability and uncontrolled cell growth. Recent research suggests that microRNAs (miRNAs) have a role in HPV-mediated tumor development, with dysregulation of particular miRNAs influencing cancer cell proliferation, immune escape, and therapy resistance. This review summarizes the most recent research on HPV’s molecular interactions with host miRNAs, focusing on their functions in regulating tumor-suppressive genes and oncogenic mechanisms. Furthermore, we investigate HPV-induced epigenetic alterations that contribute to miRNA dysregulation and corresponding changes in cell cycle control, apoptosis, and metastasis. Discovering these molecular interactions provides fresh insights into personalized medicine techniques for CC detection and therapy. Graphical abstract |
| format | Article |
| id | doaj-art-53e90c96f1a14ca99d7f13b0fd7d94e2 |
| institution | Kabale University |
| issn | 1750-9378 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | BMC |
| record_format | Article |
| series | Infectious Agents and Cancer |
| spelling | doaj-art-53e90c96f1a14ca99d7f13b0fd7d94e22025-08-20T03:45:47ZengBMCInfectious Agents and Cancer1750-93782025-07-0120113710.1186/s13027-025-00677-9Molecular interaction of human papilloma virus (HPV) with microRANs: insights into the development of cervical cancer and treatment approachesSeyedeh Mahdieh Khoshnazar0Navvabeh Salarizadeh1Maryam Mohammad-Sadeghipour2Amirhossein Shahpar3Morteza Izadi4Mohammad Javad Behzadnia5Mahdi Farhadi Khoozani6Mina Alimohammadi7Najma Farahani8Kiavash Hushmandi9Physiology Research Center, Institute of Neuropharmacology, Kerman University of Medical SciencesDepartment of Biochemistry, School of Medicine, Baqiyatallah University of Medical SciencesOccupational Safety and Health Research Center, NICICO, World Safety Organization and Rafsanjan University of Medical SciencesGastroenterology and Hepatology Research Center, Institute of Basic and Clinical Physiology Sciences, Kerman University of Medical SciencesHealth Research Center, Life Style Institute, Baqiyatallah University of Medical SciencesTrauma Research Center, Baqiyatallah University of Medical SciencesDepartment of Cell and Molecular Sciences, Faculty of Biological Sciences, Kharazmi UniversityDepartment of Immunology, School of Medicine, Shahid Beheshti University of Medical SciencesFarhikhtegan Medical Convergence Sciences Research Center, Farhikhtegan Hospital, TMs.C., Islamic Azad UniversityNephrology and Urology Research Center, Clinical Sciences Institute, Baqiyatallah University of Medical SciencesAbstract Cervical cancer is one of the leading causes of cancer-related death among women worldwide, and high-risk human papillomavirus (HR-HPV) plays a crucial role in its development. HPV’s oncogenic processes include the viral oncoproteins E6 and E7, which interfere with essential biological processes, causing DNA instability and uncontrolled cell growth. Recent research suggests that microRNAs (miRNAs) have a role in HPV-mediated tumor development, with dysregulation of particular miRNAs influencing cancer cell proliferation, immune escape, and therapy resistance. This review summarizes the most recent research on HPV’s molecular interactions with host miRNAs, focusing on their functions in regulating tumor-suppressive genes and oncogenic mechanisms. Furthermore, we investigate HPV-induced epigenetic alterations that contribute to miRNA dysregulation and corresponding changes in cell cycle control, apoptosis, and metastasis. Discovering these molecular interactions provides fresh insights into personalized medicine techniques for CC detection and therapy. Graphical abstracthttps://doi.org/10.1186/s13027-025-00677-9Cervical cancerHPVMiRNAsMolecular pathwaysTherapeutic applications |
| spellingShingle | Seyedeh Mahdieh Khoshnazar Navvabeh Salarizadeh Maryam Mohammad-Sadeghipour Amirhossein Shahpar Morteza Izadi Mohammad Javad Behzadnia Mahdi Farhadi Khoozani Mina Alimohammadi Najma Farahani Kiavash Hushmandi Molecular interaction of human papilloma virus (HPV) with microRANs: insights into the development of cervical cancer and treatment approaches Infectious Agents and Cancer Cervical cancer HPV MiRNAs Molecular pathways Therapeutic applications |
| title | Molecular interaction of human papilloma virus (HPV) with microRANs: insights into the development of cervical cancer and treatment approaches |
| title_full | Molecular interaction of human papilloma virus (HPV) with microRANs: insights into the development of cervical cancer and treatment approaches |
| title_fullStr | Molecular interaction of human papilloma virus (HPV) with microRANs: insights into the development of cervical cancer and treatment approaches |
| title_full_unstemmed | Molecular interaction of human papilloma virus (HPV) with microRANs: insights into the development of cervical cancer and treatment approaches |
| title_short | Molecular interaction of human papilloma virus (HPV) with microRANs: insights into the development of cervical cancer and treatment approaches |
| title_sort | molecular interaction of human papilloma virus hpv with microrans insights into the development of cervical cancer and treatment approaches |
| topic | Cervical cancer HPV MiRNAs Molecular pathways Therapeutic applications |
| url | https://doi.org/10.1186/s13027-025-00677-9 |
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