Pivotal role of MiRNA's in malignant transformation of Oral Submucous Fibrosis
This review explores MicroRNAs' (miRNAs) role in Oral Submucous Fibrosis (OSMF) malignant transformation. OSMF, a potentially life-threatening disorder, exhibits a 7.6% to 13% probability of malignant transformation. MiRNAs like miR-21 and miR-29b play crucial roles in OSMF pathogenesis, affect...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-06-01
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| Series: | Oral Oncology Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2772906024001456 |
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| author | J.H. Shazia Fathima Selvaraj Jayaraman Asma Abdullah Nurul Ramya Sekar Inamul Hasan Madar Logalakshmi Thirumani Nazmul Huda Syed |
| author_facet | J.H. Shazia Fathima Selvaraj Jayaraman Asma Abdullah Nurul Ramya Sekar Inamul Hasan Madar Logalakshmi Thirumani Nazmul Huda Syed |
| author_sort | J.H. Shazia Fathima |
| collection | DOAJ |
| description | This review explores MicroRNAs' (miRNAs) role in Oral Submucous Fibrosis (OSMF) malignant transformation. OSMF, a potentially life-threatening disorder, exhibits a 7.6% to 13% probability of malignant transformation. MiRNAs like miR-21 and miR-29b play crucial roles in OSMF pathogenesis, affecting fibrosis and malignancy. Their dysregulation impacts TGF-/Smad and Wnt/-catenin signaling pathways, contributing to fibrotic alterations. OSMF malignant transformation involves genetic and epigenetic changes, with miR-34 and miR-1246 implicated in increased cell proliferation and invasiveness. MiRNAs hold diagnostic and prognostic potential in OSMF. Specific miRNA signatures correlate with disease development, aiding in individualized risk stratification. Integrating miRNA-based techniques into precision medicine offers personalized therapeutic avenues, considering ethnic and environmental factors. MiRNA-targeted therapies, potentially combined with conventional approaches, show promise in addressing OSMF complexities. However, challenges in standardization, sample variability, and off-target effects persist. Artificial Intelligence contributes to miRNA research, enhancing target prediction and understanding disease mechanisms. Continued research is crucial for identifying additional OSMF-related miRNAs and refining diagnostic and therapeutic strategies. Standardization in miRNA-based diagnostics is imperative for future implementation. |
| format | Article |
| id | doaj-art-53e2ef6501994e63aaf9155ffa3223a2 |
| institution | Kabale University |
| issn | 2772-9060 |
| language | English |
| publishDate | 2024-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Oral Oncology Reports |
| spelling | doaj-art-53e2ef6501994e63aaf9155ffa3223a22025-01-09T06:15:43ZengElsevierOral Oncology Reports2772-90602024-06-0110100299Pivotal role of MiRNA's in malignant transformation of Oral Submucous FibrosisJ.H. Shazia Fathima0Selvaraj Jayaraman1Asma Abdullah Nurul2Ramya Sekar3Inamul Hasan Madar4Logalakshmi Thirumani5Nazmul Huda Syed6Department of Biochemistry, Saveetha Dental College & Hospitals, Saveetha Institute of Medical and Technical Sciences, Velappanchavadi, Chennai, 600 077, Tamil Nadu, India; Department of Oral & Maxillofacial Pathology, Ragas Dental College and Hospital, Chennai, IndiaDepartment of Biochemistry, Saveetha Dental College & Hospitals, Saveetha Institute of Medical and Technical Sciences, Velappanchavadi, Chennai, 600 077, Tamil Nadu, IndiaSchool of Health Sciences, Universiti Sains Malaysia, 16150, Kubang Kerian, Kelantan, MalaysiaDepartment of Biochemistry, Saveetha Dental College & Hospitals, Saveetha Institute of Medical and Technical Sciences, Velappanchavadi, Chennai, 600 077, Tamil Nadu, India; Department of Oral Pathology & Microbiology, Meenakshi Ammal Dental College & Hospitals, MAHER, Alapakkam Main Road, Maduravoyal, Chennai, 95, TN, IndiaMultiomics and Precision Medicine Laboratory, Centre for Global Health Research, Saveetha Medical College and Hospital, Saveetha Institute of Medical and Technical Sciences, Chennai, IndiaMultiomics and Precision Medicine Laboratory, Centre for Global Health Research, Saveetha Medical College and Hospital, Saveetha Institute of Medical and Technical Sciences, Chennai, IndiaSchool of Health Sciences, Universiti Sains Malaysia, 16150, Kubang Kerian, Kelantan, Malaysia; Center for Global Health Research, Saveetha Medical College and Hospital, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, India; Corresponding author. Center for Global Health Research, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, India.This review explores MicroRNAs' (miRNAs) role in Oral Submucous Fibrosis (OSMF) malignant transformation. OSMF, a potentially life-threatening disorder, exhibits a 7.6% to 13% probability of malignant transformation. MiRNAs like miR-21 and miR-29b play crucial roles in OSMF pathogenesis, affecting fibrosis and malignancy. Their dysregulation impacts TGF-/Smad and Wnt/-catenin signaling pathways, contributing to fibrotic alterations. OSMF malignant transformation involves genetic and epigenetic changes, with miR-34 and miR-1246 implicated in increased cell proliferation and invasiveness. MiRNAs hold diagnostic and prognostic potential in OSMF. Specific miRNA signatures correlate with disease development, aiding in individualized risk stratification. Integrating miRNA-based techniques into precision medicine offers personalized therapeutic avenues, considering ethnic and environmental factors. MiRNA-targeted therapies, potentially combined with conventional approaches, show promise in addressing OSMF complexities. However, challenges in standardization, sample variability, and off-target effects persist. Artificial Intelligence contributes to miRNA research, enhancing target prediction and understanding disease mechanisms. Continued research is crucial for identifying additional OSMF-related miRNAs and refining diagnostic and therapeutic strategies. Standardization in miRNA-based diagnostics is imperative for future implementation.http://www.sciencedirect.com/science/article/pii/S2772906024001456Oral submucous fibrosismicroRNABiomarkersOral cancerMalignant transformation |
| spellingShingle | J.H. Shazia Fathima Selvaraj Jayaraman Asma Abdullah Nurul Ramya Sekar Inamul Hasan Madar Logalakshmi Thirumani Nazmul Huda Syed Pivotal role of MiRNA's in malignant transformation of Oral Submucous Fibrosis Oral Oncology Reports Oral submucous fibrosis microRNA Biomarkers Oral cancer Malignant transformation |
| title | Pivotal role of MiRNA's in malignant transformation of Oral Submucous Fibrosis |
| title_full | Pivotal role of MiRNA's in malignant transformation of Oral Submucous Fibrosis |
| title_fullStr | Pivotal role of MiRNA's in malignant transformation of Oral Submucous Fibrosis |
| title_full_unstemmed | Pivotal role of MiRNA's in malignant transformation of Oral Submucous Fibrosis |
| title_short | Pivotal role of MiRNA's in malignant transformation of Oral Submucous Fibrosis |
| title_sort | pivotal role of mirna s in malignant transformation of oral submucous fibrosis |
| topic | Oral submucous fibrosis microRNA Biomarkers Oral cancer Malignant transformation |
| url | http://www.sciencedirect.com/science/article/pii/S2772906024001456 |
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