PI3K/AKT/PTEN Signaling as a Molecular Target in Leukemia Angiogenesis
PI3K/AKT/PTEN pathway is important in the regulation of angiogenesis mediated by vascular endothelial growth factor in many tumors including leukemia. The signaling pathway is activated in leukemia patients as well as leukemia cell lines together with a decrease in the expression of PTEN gene. The m...
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Main Authors: | Naoko Okumura, Hitomi Yoshida, Yasuko Kitagishi, Mutsumi Murakami, Yuri Nishimura, Satoru Matsuda |
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Format: | Article |
Language: | English |
Published: |
Wiley
2012-01-01
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Series: | Advances in Hematology |
Online Access: | http://dx.doi.org/10.1155/2012/843085 |
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