The Influence of polycyclic aromatic hydrocarbons exposure on the gut microbiome composition and inflammatory responses
Particulate matter (PM) is recognized as a contributor to various gastrointestinal diseases, including inflammatory bowel disease. However, the specific impact of polycyclic aromatic hydrocarbons (PAHs), a major component of PM, on microbial community dynamics and immune regulation remains unexplore...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-09-01
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| Series: | Ecotoxicology and Environmental Safety |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0147651325012552 |
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| author | Song Hee Jeong Jaejoon Jung Young-Jun Park Sang Jun Lee Seon-Jin Lee |
| author_facet | Song Hee Jeong Jaejoon Jung Young-Jun Park Sang Jun Lee Seon-Jin Lee |
| author_sort | Song Hee Jeong |
| collection | DOAJ |
| description | Particulate matter (PM) is recognized as a contributor to various gastrointestinal diseases, including inflammatory bowel disease. However, the specific impact of polycyclic aromatic hydrocarbons (PAHs), a major component of PM, on microbial community dynamics and immune regulation remains unexplored. In this study, we investigated the effects of PAHs on the inflammatory response of mouse intestinal tissues and microbiota composition using PAHs extracted from PM10 (PM10_PAHs). With increasing duration of exposure to PM10_PAHs, damage to the colonic mucosa and lung tissues was aggravated and the secretion of inflammatory cytokines increased. The composition of the gut microbiota was also significantly altered, with a decrease in Firmicutes and an increase in Bacteroidetes at the phylum level, along with an increase in Lactobacillus, Clostridium, and Romboutsia at the genus level. Notably, despite the cessation of PM10_PAHs administration and the recovery of gut microbial diversity, the microbiota composition and inflammatory cytokine levels did not return to pre-exposure conditions. These results suggest that exposure to PM can have lasting adverse health effects, such as inflammation induced by its main component, PAHs. |
| format | Article |
| id | doaj-art-53d7dc3f00794d77a8b204f3784dcc95 |
| institution | Kabale University |
| issn | 0147-6513 |
| language | English |
| publishDate | 2025-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Ecotoxicology and Environmental Safety |
| spelling | doaj-art-53d7dc3f00794d77a8b204f3784dcc952025-08-23T04:47:24ZengElsevierEcotoxicology and Environmental Safety0147-65132025-09-0130311891010.1016/j.ecoenv.2025.118910The Influence of polycyclic aromatic hydrocarbons exposure on the gut microbiome composition and inflammatory responsesSong Hee Jeong0Jaejoon Jung1Young-Jun Park2Sang Jun Lee3Seon-Jin Lee4Department of Systems Biotechnology, and Institute of Microbiomics, Chung-Ang University, Anseong 17546, Republic of KoreaDepartment of Microbiology and Immunology, College of Medicine, Seoul National University, Seoul 03080, Republic of KoreaEnvironmental Disease Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, 34141, Republic of KoreaDepartment of Systems Biotechnology, and Institute of Microbiomics, Chung-Ang University, Anseong 17546, Republic of Korea; Corresponding authors.Environmental Disease Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, 34141, Republic of Korea; Corresponding authors.Particulate matter (PM) is recognized as a contributor to various gastrointestinal diseases, including inflammatory bowel disease. However, the specific impact of polycyclic aromatic hydrocarbons (PAHs), a major component of PM, on microbial community dynamics and immune regulation remains unexplored. In this study, we investigated the effects of PAHs on the inflammatory response of mouse intestinal tissues and microbiota composition using PAHs extracted from PM10 (PM10_PAHs). With increasing duration of exposure to PM10_PAHs, damage to the colonic mucosa and lung tissues was aggravated and the secretion of inflammatory cytokines increased. The composition of the gut microbiota was also significantly altered, with a decrease in Firmicutes and an increase in Bacteroidetes at the phylum level, along with an increase in Lactobacillus, Clostridium, and Romboutsia at the genus level. Notably, despite the cessation of PM10_PAHs administration and the recovery of gut microbial diversity, the microbiota composition and inflammatory cytokine levels did not return to pre-exposure conditions. These results suggest that exposure to PM can have lasting adverse health effects, such as inflammation induced by its main component, PAHs.http://www.sciencedirect.com/science/article/pii/S0147651325012552Particulate matter 10Polycyclic aromatic hydrocarbonsInflammatory bowel diseaseGut microbiomeInflammatory response |
| spellingShingle | Song Hee Jeong Jaejoon Jung Young-Jun Park Sang Jun Lee Seon-Jin Lee The Influence of polycyclic aromatic hydrocarbons exposure on the gut microbiome composition and inflammatory responses Ecotoxicology and Environmental Safety Particulate matter 10 Polycyclic aromatic hydrocarbons Inflammatory bowel disease Gut microbiome Inflammatory response |
| title | The Influence of polycyclic aromatic hydrocarbons exposure on the gut microbiome composition and inflammatory responses |
| title_full | The Influence of polycyclic aromatic hydrocarbons exposure on the gut microbiome composition and inflammatory responses |
| title_fullStr | The Influence of polycyclic aromatic hydrocarbons exposure on the gut microbiome composition and inflammatory responses |
| title_full_unstemmed | The Influence of polycyclic aromatic hydrocarbons exposure on the gut microbiome composition and inflammatory responses |
| title_short | The Influence of polycyclic aromatic hydrocarbons exposure on the gut microbiome composition and inflammatory responses |
| title_sort | influence of polycyclic aromatic hydrocarbons exposure on the gut microbiome composition and inflammatory responses |
| topic | Particulate matter 10 Polycyclic aromatic hydrocarbons Inflammatory bowel disease Gut microbiome Inflammatory response |
| url | http://www.sciencedirect.com/science/article/pii/S0147651325012552 |
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