Comprehensive profiling of the catalytic conformations of human Guanylate kinase

Comprehensive profiling of the catalytic conformations of human Guanylate kinase

Abstract Human guanylate kinase (GMPK) as the sole enzyme for GDP biosynthesis plays pivotal roles in antiviral prodrug activation and tumorigenesis. Despite its biological significance, the catalytic mechanism remains poorly understood. Here, we resolve crystal structures of GMPK in free and GMP-bo...

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Main Authors: Lei Wang, Zihuan Li, Yumi Xuan, Jingkun Qin, Shuju Li, Fumei Zhong, Yuexiao Song, Kanglong Yang, Mengqi Lv, Fudong Li, Zhang Jiahai, Yueyin Pan, Shouhong Guang, Yuzheng Zhao, Yunyu Shi, Xing Liu, Yingying Du, Jia Gao, Ke Ruan
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-61732-y
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