Sequencing a DNA analog composed of artificial bases

Sequencing a DNA analog composed of artificial bases

Abstract “ALternative Isoinformational ENgineered” (ALIEN) DNA is a biomimetic polymer composed of four entirely anthropogenic nucleotides. These alternative nucleosides form base pairs orthogonal to canonical bases and fold into the familiar B-form DNA double-helix, endowing ALIEN DNA with valuable...

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Main Authors: Christopher A. Thomas, Henry Brinkerhoff, Jonathan M. Craig, Shuichi Hoshika, Desislava Mihaylova, Akira M. Pfeffer, Michaela C. Franzi, Sarah J. Abell, Jessica D. Carrasco, Jens H. Gundlach, Steven A. Benner, Andrew H. Laszlo
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-61991-9
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https://doi.org/10.1038/s41467-025-61991-9

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