Cerebrovascular Burden and Its Association with Ménière’s Disease: A Case-Control Study
<b>Background</b>: Ménière’s disease (MD) lacks a universally accepted pathogenesis model. Recent research has revisited the vascular hypothesis. This study aims to compare the cerebrovascular burden in patients with MD and age-matched controls, investigating the potential role of cerebr...
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MDPI AG
2024-09-01
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| Series: | Journal of Otorhinolaryngology, Hearing and Balance Medicine |
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| author | Francisco Alves de Sousa João Tarrio Bruno Moreira Ana Nóbrega Pinto Luís Meireles Ângela Reis Rego |
| author_facet | Francisco Alves de Sousa João Tarrio Bruno Moreira Ana Nóbrega Pinto Luís Meireles Ângela Reis Rego |
| author_sort | Francisco Alves de Sousa |
| collection | DOAJ |
| description | <b>Background</b>: Ménière’s disease (MD) lacks a universally accepted pathogenesis model. Recent research has revisited the vascular hypothesis. This study aims to compare the cerebrovascular burden in patients with MD and age-matched controls, investigating the potential role of cerebrovascular dysfunction in MD. <b>Methods</b>: A total of 145 patients (70 MD, 75 controls) underwent magnetic resonance imaging (MRI) assessment for small-vessel disease (SVD) markers (including Fazekas and EPVS scores), cortical strokes, and baseline comorbidities. Statistical analyses were performed to compare the cerebrovascular burden between the groups, adjusting for potential confounders. <b>Results</b>: The MD group exhibited significantly higher mean SVD scores across various measures compared to controls (<i>p</i> < 0.05). This association persisted even after adjusting for age, sex, and comorbidities (ORs ranging from 1.746 to 2.495, <i>p</i> < 0.05). Neither the presence of cortical strokes nor comorbidities significantly differed between groups. <b>Conclusions</b>: This study is the first to compare cerebrovascular burden between MD patients and controls. The findings suggest that cerebrovascular dysfunction may contribute to MD incidence. Further research is needed to elucidate the relationship between cerebrovascular disease and MD, potentially leading to novel therapeutic avenues. |
| format | Article |
| id | doaj-art-5387b593c8004d5ab9b1076670ee54b9 |
| institution | Kabale University |
| issn | 2504-463X |
| language | English |
| publishDate | 2024-09-01 |
| publisher | MDPI AG |
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| series | Journal of Otorhinolaryngology, Hearing and Balance Medicine |
| spelling | doaj-art-5387b593c8004d5ab9b1076670ee54b92024-12-27T14:44:38ZengMDPI AGJournal of Otorhinolaryngology, Hearing and Balance Medicine2504-463X2024-09-01521310.3390/ohbm5020013Cerebrovascular Burden and Its Association with Ménière’s Disease: A Case-Control StudyFrancisco Alves de Sousa0João Tarrio1Bruno Moreira2Ana Nóbrega Pinto3Luís Meireles4Ângela Reis Rego5Otorhinolaryngology and Head & Neck Surgery Department, Unidade Local de Saúde de Santo António, 4099-001 Porto, PortugalNeurorradiology Department, Unidade Local de Saúde de Santo António, 4099-001 Porto, PortugalNeurorradiology Department, Unidade Local de Saúde de Santo António, 4099-001 Porto, PortugalOtorhinolaryngology and Head & Neck Surgery Department, Unidade Local de Saúde de Santo António, 4099-001 Porto, PortugalOtorhinolaryngology and Head & Neck Surgery Department, Unidade Local de Saúde de Santo António, 4099-001 Porto, PortugalOtorhinolaryngology, Instituto CUF Porto, 4460-188 Porto, Portugal<b>Background</b>: Ménière’s disease (MD) lacks a universally accepted pathogenesis model. Recent research has revisited the vascular hypothesis. This study aims to compare the cerebrovascular burden in patients with MD and age-matched controls, investigating the potential role of cerebrovascular dysfunction in MD. <b>Methods</b>: A total of 145 patients (70 MD, 75 controls) underwent magnetic resonance imaging (MRI) assessment for small-vessel disease (SVD) markers (including Fazekas and EPVS scores), cortical strokes, and baseline comorbidities. Statistical analyses were performed to compare the cerebrovascular burden between the groups, adjusting for potential confounders. <b>Results</b>: The MD group exhibited significantly higher mean SVD scores across various measures compared to controls (<i>p</i> < 0.05). This association persisted even after adjusting for age, sex, and comorbidities (ORs ranging from 1.746 to 2.495, <i>p</i> < 0.05). Neither the presence of cortical strokes nor comorbidities significantly differed between groups. <b>Conclusions</b>: This study is the first to compare cerebrovascular burden between MD patients and controls. The findings suggest that cerebrovascular dysfunction may contribute to MD incidence. Further research is needed to elucidate the relationship between cerebrovascular disease and MD, potentially leading to novel therapeutic avenues.https://www.mdpi.com/2504-463X/5/2/13Ménière’s diseasebraincerebrovascular diseasestrokecardiovascular risk factorsmagnetic resonance imaging |
| spellingShingle | Francisco Alves de Sousa João Tarrio Bruno Moreira Ana Nóbrega Pinto Luís Meireles Ângela Reis Rego Cerebrovascular Burden and Its Association with Ménière’s Disease: A Case-Control Study Journal of Otorhinolaryngology, Hearing and Balance Medicine Ménière’s disease brain cerebrovascular disease stroke cardiovascular risk factors magnetic resonance imaging |
| title | Cerebrovascular Burden and Its Association with Ménière’s Disease: A Case-Control Study |
| title_full | Cerebrovascular Burden and Its Association with Ménière’s Disease: A Case-Control Study |
| title_fullStr | Cerebrovascular Burden and Its Association with Ménière’s Disease: A Case-Control Study |
| title_full_unstemmed | Cerebrovascular Burden and Its Association with Ménière’s Disease: A Case-Control Study |
| title_short | Cerebrovascular Burden and Its Association with Ménière’s Disease: A Case-Control Study |
| title_sort | cerebrovascular burden and its association with meniere s disease a case control study |
| topic | Ménière’s disease brain cerebrovascular disease stroke cardiovascular risk factors magnetic resonance imaging |
| url | https://www.mdpi.com/2504-463X/5/2/13 |
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